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Found 42 with Last Name = 'becq' and Initial = 'f'
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50343996(2,4-dimethylpyrido[1,2-a]pyrimidin-5-ium-3-olate |...)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50343998((2S,3R,4R)-3,4-dihydroxy-2,4-dimethyl-3,4-dihydro-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50343998((2S,3R,4R)-3,4-dihydroxy-2,4-dimethyl-3,4-dihydro-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50343997(2,4-dimethylpyrimido[2,1-a]isoquinolin-5-ium-3-ola...)
Affinity DataIC50:  16nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140147(2-{4-[5-(4-Methoxy-phenyl)-thiazol-2-yl]-benzenesu...)
Affinity DataIC50:  50nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140147(2-{4-[5-(4-Methoxy-phenyl)-thiazol-2-yl]-benzenesu...)
Affinity DataIC50:  50nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140146((S)-3-((R)-Isobutyl)-4-oxo-6-((R)-phenylmethyl)-2-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140146((S)-3-((R)-Isobutyl)-4-oxo-6-((R)-phenylmethyl)-2-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140149(2-{4-[5-(4-Methoxy-phenyl)-thiazol-2-yl]-benzenesu...)
Affinity DataIC50:  200nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140150(CHEMBL13974 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)...)
Affinity DataIC50:  400nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140149(2-{4-[5-(4-Methoxy-phenyl)-thiazol-2-yl]-benzenesu...)
Affinity DataIC50:  700nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140150(CHEMBL13974 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)...)
Affinity DataIC50:  900nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140148(2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesul...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140148(2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesul...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140145(CHEMBL13826 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140145(CHEMBL13826 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140151(5-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesul...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140151(5-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesul...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50564154(CHEMBL4788315)
Affinity DataEC50:  870nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50564153(CHEMBL4794876)
Affinity DataEC50:  1.51E+3nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139826(10-Chloro-6-hydroxy-5-propyl-pyrido[1,2-a]quinolin...)
Affinity DataEC50:  5.42E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139825(5-Butyl-10-chloro-6-hydroxy-pyrido[1,2-a]quinoliny...)
Affinity DataEC50:  2.35E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139829(5-Ethoxycarbonyl-10-fluoro-6-hydroxy-pyrido[1,2-a]...)
Affinity DataEC50:  7.05E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139823(10-Chloro-6-hydroxy-5-isobutyl-pyrido[1,2-a]quinol...)
Affinity DataEC50:  2.60E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139829(5-Ethoxycarbonyl-10-fluoro-6-hydroxy-pyrido[1,2-a]...)
Affinity DataEC50:  9.50E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139828(10-Chloro-6-hydroxy-5-pentyl-pyrido[1,2-a]quinolin...)
Affinity DataEC50:  2.00E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139828(10-Chloro-6-hydroxy-5-pentyl-pyrido[1,2-a]quinolin...)
Affinity DataEC50:  2.10E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139827(5-Butyl-7-chloro-6-hydroxy-pyrido[1,2-a]quinolinyl...)
Affinity DataEC50:  1.70E+3nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139827(5-Butyl-7-chloro-6-hydroxy-pyrido[1,2-a]quinolinyl...)
Affinity DataEC50:  750nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139822(10-Chloro-6-hydroxy-pyrido[1,2-a]quinolinylium; ch...)
Affinity DataEC50: >2.00E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139826(10-Chloro-6-hydroxy-5-propyl-pyrido[1,2-a]quinolin...)
Affinity DataEC50:  4.80E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139825(5-Butyl-10-chloro-6-hydroxy-pyrido[1,2-a]quinoliny...)
Affinity DataEC50:  3.40E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139824(7-Chloro-6-hydroxy-pyrido[1,2-a]quinolinylium; chl...)
Affinity DataEC50: >2.00E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139824(7-Chloro-6-hydroxy-pyrido[1,2-a]quinolinylium; chl...)
Affinity DataEC50:  1.46E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139823(10-Chloro-6-hydroxy-5-isobutyl-pyrido[1,2-a]quinol...)
Affinity DataEC50:  3.20E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50139822(10-Chloro-6-hydroxy-pyrido[1,2-a]quinolinylium; ch...)
Affinity DataEC50:  1.41E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  12nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50023202(CHEMBL3298813)
Affinity DataEC50:  2.10E+3nMAssay Description:Activation of wild-type CFTR (unknown origin) expressed in forskolin-stimulated CHO cells assessed as increase in iodide efflux by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs

Curated by ChEMBL
LigandPNGBDBM50023201(CHEMBL3298812)
Affinity DataEC50:  7.50E+3nMAssay Description:Activation of wild-type CFTR (unknown origin) expressed in forskolin-stimulated CHO cells assessed as increase in iodide efflux by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed