TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 870nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 1.51E+3nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 5.42E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 2.35E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 7.05E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 2.60E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 9.50E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 2.00E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 2.10E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 1.70E+3nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 750nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: >2.00E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 4.80E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 3.40E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: >2.00E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 1.46E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 3.20E+4nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 1.41E+5nMAssay Description:Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 microM FskMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 2.10E+3nMAssay Description:Activation of wild-type CFTR (unknown origin) expressed in forskolin-stimulated CHO cells assessed as increase in iodide efflux by gamma countingMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/Cnrs
Curated by ChEMBL
Affinity DataEC50: 7.50E+3nMAssay Description:Activation of wild-type CFTR (unknown origin) expressed in forskolin-stimulated CHO cells assessed as increase in iodide efflux by gamma countingMore data for this Ligand-Target Pair