TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.16nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 3.16nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5.01nMAssay Description:Binding affinity to human EP3More data for this Ligand-Target Pair
Affinity DataKi: 6.31nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
Affinity DataKi: 7.94nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 12.6nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 19.9nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
Affinity DataKi: 210nM ΔG°: -38.1kJ/mole IC50: 650nMpH: 7.5 T: 2°CAssay Description:An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...More data for this Ligand-Target Pair
Affinity DataKi: 290nM ΔG°: -37.3kJ/mole IC50: 140nMpH: 7.5 T: 2°CAssay Description:An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...More data for this Ligand-Target Pair
Affinity DataKi: 316nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 470nM ΔG°: -36.1kJ/mole IC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...More data for this Ligand-Target Pair
Affinity DataKi: >5.01E+3nMAssay Description:Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assayMore data for this Ligand-Target Pair
TargetGlucose-1-phosphate cytidylyltransferase(Salmonella typhi)
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataKi: 3.50E+4nMAssay Description:Binding affinity to Salmonella typhi glucose-1-phosphate cytidylyl-transferase assessed as dissociation constant by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >5.01E+4nMAssay Description:Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: >2nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Stony Brook University
Curated by ChEMBL
Stony Brook University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >10nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: >10nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: >10nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:In vitro inhibitory activity against collagenase-1(MMP-1).More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:In vitro inhibitory activity against stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair