Compile Data Set for Download or QSAR
maximum 50k data
Found 2559 with Last Name = 'de man' and Initial = 'ap'
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118719(7-Amino-3-{[1-(2-amino-3-cyclohexyl-propionyl)-pyr...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118730(7-Amino-3-(2-{[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.210nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118739(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118728(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118732(1-(2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118729(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.330nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118731((2-{2-[5-Amino-1-(oxazole-2-carbonyl)-pentylcarbam...)
Affinity DataKi:  0.420nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118735(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118738(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.820nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118718(CHEMBL343804 | {2-[2-(5-Amino-1-phenethylaminooxal...)
Affinity DataKi:  0.840nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118723(CHEMBL342672 | CYCLOTHEONAMIDE A | N-[14-Benzyl-18...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118727(2-((R)-1-((S)-2-(((S)-7-amino-1-isopropoxy-1,2-dio...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118720(7-Amino-3-{[1-(2-amino-3-phenyl-propionyl)-pyrroli...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118717((S)-N-((S)-6-amino-1-oxo-1-(thiazol-2-yl)hexan-2-y...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118737((2-{2-[5-Amino-1-(thiazole-2-carbonyl)-pentylcarba...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118721((S)-N-((S)-6-amino-1-oxo-1-(thiazol-2-yl)hexan-2-y...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118722(2-Amino-N-{[5-amino-1-(thiazole-2-carbonyl)-pentyl...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataKi:  15nMAssay Description:The inhibitory activity of the compound was tested against thrombin (IIa)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118725(7-Amino-3-{[1-(3-carboxy-2-phenylmethanesulfonylam...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118734(6-Amino-2-[2-(5-{[1-(2-amino-3-phenyl-propionyl)-p...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118724((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  146nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118716((S)-1-(3,3-diphenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataKi:  204nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118715(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  376nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataKi:  675nMAssay Description:The inhibitory activity of the compound was tested against trypsinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118714(7-Methoxy-naphthalene-2-sulfonic acid [5-amino-1-(...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118733(1-(3,3-Diphenyl-propionyl)-pyrrolidine-2-carboxyli...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118726(CHEMBL334701 | N-[5-Amino-1-(thiazole-2-carbonyl)-...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118736(7-Methoxy-naphthalene-2-sulfonic acid [5-amino-1-(...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532308(JDM666A | N-(2,6-dimethylphenyl-2-[4-[4-[2-ethylam...)
Affinity DataIC50:  0.410nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532304(JDM697A | N-[1-[2-(2-ethoxyethoxy)ethyl]-3,5-dieth...)
Affinity DataIC50:  0.410nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532306(JDM703A | N-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)...)
Affinity DataIC50:  0.430nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532294(JDM0684A | N-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy...)
Affinity DataIC50:  0.430nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532285(N-(2,6-diethylphenyl)-8-(2-methoxy-4-piperazin-1-y...)
Affinity DataIC50:  0.490nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532289(JGS439C | N-(2,6-dimethylphenyl)-2-[2-methoxy-4-(t...)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532292(JGS79C | N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-m...)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM258443(US11208696, Example 6 | US9512130, 1)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532301(JDM677A | N-[1-[2-[2-(2-methoxyethoxy)ethoxyethyl]...)
Affinity DataIC50:  0.620nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50:  0.630nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM258445(US11208696, Example 5 | US9512130, 3)
Affinity DataIC50:  0.650nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532307(2-[4-[4-[(2R)-azetidine-2-carbonyl]piperazin-1-yl]...)
Affinity DataIC50:  0.660nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532288(N-(2,6-dimethylphenyl)-2-(2-methyl-4-piperazin-1-y...)
Affinity DataIC50:  0.700nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532303(JDM713A | N-[3,5-diethyl-1-[2-(2-methoxyethoxy)eth...)
Affinity DataIC50:  0.710nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532290(JDM0641A | N-[1-[2-[2-(2-methoxyethoxyethoxy]ethyl...)
Affinity DataIC50:  0.730nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532309(JGS0715B | N-cyclopropyl-4-[6-(2,3-difluoro-4-meth...)
Affinity DataIC50:  0.790nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532305(JDM636A | N-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)...)
Affinity DataIC50:  0.910nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532291(JDM0443A | N-[1-[2-[2-(2-methoxyethoxy)ethoxy]ethy...)
Affinity DataIC50:  0.930nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532302(JDM711A | N-[3,5-diethyl-1-[2-(2-methoxyethoxy eth...)
Affinity DataIC50:  0.960nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532293(N-(3,5-diethyl-1H-pyrazol-4-yl)-2-[2-(difluorometh...)
Affinity DataIC50:  0.970nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Displayed 1 to 50 (of 2559 total ) | Next | Last >>
Jump to: