Compile Data Set for Download or QSAR
maximum 50k data
Found 119 of ic50 for monomerid = 23971
TargetCytosol aminopeptidase(Bos taurus (bovine))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosol aminopeptidase(Bos taurus (bovine))
Merck Sharpe And Dohme

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  0.5nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBacterial leucyl aminopeptidase(Vibrio proteolyticus)
Enscmu

LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.60nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrateMore data for this Ligand-Target Pair
TargetAminopeptidase B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  160nMAssay Description:Inhibition of rat liver aminopeptidase B using 0.2 mM L-leucine-beta-naphthylamide by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  266nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged LTA4H expressed in Escherichia coli BL21 DE3 cells assessed as reduction in amino-...More data for this Ligand-Target Pair
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
Universit£

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  284nMAssay Description:Inhibitory activity for Plasmodium falciparum Zinc aminopeptidaseMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate pr...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  500nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  500nMAssay Description:Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase by Dixon plot analysisMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged APN (Lys69 to Lys967 residues) using Ala-AMC as substrate measured for 30 mins by fluorescenc...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibition of pig kidney microsomal APN using L-Leu-p-nitroanilide as substrate preincubated for 5 mins before substrate addition measured after 30 m...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of pig kidney aminopeptidase N using Leu-AMC as substrateMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of pig kidney aminopeptidase NMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilideMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 minsMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of aminopeptidase NMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of porcine kidney CD13 using L-leucine-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.50E+3nMpH: 7.2Assay Description:Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 °C. The APN solution was mixed with compounds at v...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of aminopeptidase N (unknown origin)More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.55E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.62E+3nMAssay Description:Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against mammalian Aminopeptidase N (APN)More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of microsomal neural aminopeptidase in pig kidneyMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of pig kidney microsomal Aminopeptidase NMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometerMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of pig kidney microsomal APNMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of APN in porcine kidney microsomes preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 30 mins by plate reader ana...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetPuromycin-sensitive aminopeptidase(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-MBP-tagged PSA expressed in Escherichia coli BL21 STAR (DE3) using 4-Ala-MNA as substrate measured fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.50E+3nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human aminopeptidase N by Dixon plot analysisMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of porcine kidney microsome APN assessed as L-Leu-p-nitroanilide hydrolysisMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.64E+3nMAssay Description:Inhibition of APN in pig kidney microsomes assessed as reduction in p-nitroanilide release using L-leu-p-nitroanilide as substrate incubated for 30 m...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of pig kidney microsomal APN assessed as hydrolysis of L-Leu-p-nitroanilide after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of porcine kidney microsomal CD13 using L-leucine-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of aminopeptidase N in pig kidney microsome by spectrophotometryMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of APN from pig kidney microsomes by spectrophotometryMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibitory concentration against aminopeptidase NMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.18E+3nMAssay Description:Inhibition of pig kidney microsome aminopeptidase N after 30 mins by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  5.12E+3nMAssay Description:Inhibition of porcine kidney microsomal CD13 using L-leucine-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair
TargetCytosol aminopeptidase(Sus scrofa)
National Institute Of Public Health-National Institute Of Hygiene

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  5.55E+3nMAssay Description:Inhibition of pig kidney microsome aminopeptidase N using L-Leu-p-nitroanilide substrateMore data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  5.58E+3nMAssay Description:Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
TBA

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  5.87E+3nMT: 2°CAssay Description:Inhibition of porcine kidney microsomal APN after 10 mins at room temperature by spectrophotometryMore data for this Ligand-Target Pair
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