Compile Data Set for Download or QSAR
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Report error Found 314 Enz. Inhib. hit(s) with all data for entry = 50038381
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of EGFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM2580(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of CaM-KKbetaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  2nMAssay Description:Inhibition of human JNK1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  4nMAssay Description:Inhibition of human JNK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM2580(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataKi:  17nMAssay Description:Inhibition of human myosin light chain kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  20nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)
Affinity DataKi:  30nMAssay Description:Inhibition of adhenosine kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  35nMAssay Description:Inhibition of Cdk1/cyclin B1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataKi:  38nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  52nMAssay Description:Inhibition of human JNK3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  70nMAssay Description:Inhibition of Cdk7/cyclin HChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50319631(CHEMBL1083134 | trans-4-[(1R)-1-Aminoethyl]-N-4-py...)
Affinity DataKi:  140nMAssay Description:Inhibition of p160ROCKChecked by AuthorMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  160nMAssay Description:Inhibition of AblChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229978(5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOL...)
Affinity DataKi:  310nMAssay Description:Inhibition of p38alphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229978(5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOL...)
Affinity DataKi:  310nMAssay Description:Binding affinity to ERK1Checked by AuthorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229978(5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOL...)
Affinity DataKi:  310nMAssay Description:Inhibition of ERK2Checked by AuthorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229978(5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOL...)
Affinity DataKi:  310nMAssay Description:Inhibition of ERK1Checked by AuthorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50229978(5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOL...)
Affinity DataKi:  310nMAssay Description:Binding affinity to ERK2Checked by AuthorMore data for this Ligand-Target Pair
TargetProtein kinase C delta type(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi:  318nMAssay Description:Inhibition of PKCdeltaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)
Affinity DataKi:  530nMAssay Description:Inhibition of ERK2Checked by AuthorMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of PKCalphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of FynChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of AKTChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 3(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EphB3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50216681(1-(5-chloronaphthalen-1-ylsulfonyl)-1,4-diazepane ...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of myosin light chain kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375645(CHEMBL219301 | US11542290, Compound A-3)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of myosin light chain kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataKi:  1.01E+4nMAssay Description:Binding affinity at MLCKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50216680(1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine |...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of CaM-KKbetaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  2.83E+4nMAssay Description:Binding affinity at MLCKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  2.97E+4nMAssay Description:Inhibition of CaM-KKbetaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  3.83E+4nMAssay Description:Inhibition of casein kinase 1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375645(CHEMBL219301 | US11542290, Compound A-3)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition of casein kinase 1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50216680(1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine |...)
Affinity DataKi:  1.50E+5nMAssay Description:Binding affinity at MLCKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of wild type EGFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  0.0250nMAssay Description:Inhibition of EGFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3303(4-Anilinoquinazoline deriv. 54 | 4-N-(3-bromopheny...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of wild type EGFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM84533(Alsterpaullone derivative, 7 | BDBM50375663)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM84533(Alsterpaullone derivative, 7 | BDBM50375663)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375642(CHEMBL406381 | KRN-633)
Affinity DataIC50:  1nMAssay Description:Inhibition of human VEGFR1 in HUVEC cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375656(ARCTIGENIN)
Affinity DataIC50:  1nMAssay Description:Inhibition of MKK1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK2Checked by AuthorMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375642(CHEMBL406381 | KRN-633)
Affinity DataIC50:  1nMAssay Description:Inhibition of human VEGFR2 in HUVEC cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tyk2Checked by AuthorMore data for this Ligand-Target Pair
TargetProtein kinase C gamma type(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCgammaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCbetaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCalphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM4622(3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | An...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3KChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM25018(3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p110-alpha PI kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of VEGFR2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50375639(CHEMBL258940)
Affinity DataIC50:  3nMAssay Description:Inhibition of ErbB1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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