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Patent code US10829480

Compile Data Set for Download or QSAR

Found 296 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472033
PNG
(US10829480, Example SC_2061)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N4O/c1-29(2)27(24-11-4-3-5-12-24)15-13-26(14-16-27)21-30(19-23-10-7-17-28-18-23)25(32)31(26)20-22-8-6-9-22/h3-5,7,10-12,17-18,22H,6,8-9,13-16,19-21H2,1-2H3/t26-,27+
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GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472009
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N4O/c1-29(2)27(24-11-4-3-5-12-24)15-13-26(14-16-27)21-30(19-23-10-7-17-28-18-23)25(32)31(26)20-22-8-6-9-22/h3-5,7,10-12,17-18,22H,6,8-9,13-16,19-21H2,1-2H3/t26-,27+
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GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472098
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(3-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N3O3S/c1-30(2)29(25-12-5-4-6-13-25)17-15-28(16-18-29)22-31(27(33)32(28)21-23-9-7-10-23)20-24-11-8-14-26(19-24)36(3,34)35/h4-6,8,11-14,19,23H,7,9-10,15-18,20-22H2,1-3H3/t28-,29+
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GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471982
PNG
(CIS-2-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccccc3C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H38N4O2/c1-31(2)29(24-12-4-3-5-13-24)17-15-28(16-18-29)21-32(27(35)33(28)19-22-9-8-10-22)20-23-11-6-7-14-25(23)26(30)34/h3-7,11-14,22H,8-10,15-21H2,1-2H3,(H2,30,34)/t28-,29+
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GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471984
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cnccn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H35N5O/c1-29(2)26(22-9-4-3-5-10-22)13-11-25(12-14-26)20-30(19-23-17-27-15-16-28-23)24(32)31(25)18-21-7-6-8-21/h3-5,9-10,15-17,21H,6-8,11-14,18-20H2,1-2H3/t25-,26+
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GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472075
PNG
(CIS-3-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H36N4O/c1-31(2)29(26-12-4-3-5-13-26)16-14-28(15-17-29)22-32(20-25-11-7-10-24(18-25)19-30)27(34)33(28)21-23-8-6-9-23/h3-5,7,10-13,18,23H,6,8-9,14-17,20-22H2,1-2H3/t28-,29+
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GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472105
PNG
(CIS-3-Benzy1-1-(cyclobutyl-methyl)-8-dimethylamino...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccccc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H37N3O/c1-29(2)28(25-14-7-4-8-15-25)18-16-27(17-19-28)22-30(20-23-10-5-3-6-11-23)26(32)31(27)21-24-12-9-13-24/h3-8,10-11,14-15,24H,9,12-13,16-22H2,1-2H3/t27-,28+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472053
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccncc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N4O/c1-29(2)27(24-9-4-3-5-10-24)15-13-26(14-16-27)21-30(19-23-11-17-28-18-12-23)25(32)31(26)20-22-7-6-8-22/h3-5,9-12,17-18,22H,6-8,13-16,19-21H2,1-2H3/t26-,27+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472091
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(4-hy...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(O)cc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H37N3O2/c1-29(2)28(24-9-4-3-5-10-24)17-15-27(16-18-28)21-30(19-23-11-13-25(32)14-12-23)26(33)31(27)20-22-7-6-8-22/h3-5,9-14,22,32H,6-8,15-21H2,1-2H3/t27-,28+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472089
PNG
(CIS-3-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H38N4O2/c1-31(2)29(25-12-4-3-5-13-25)16-14-28(15-17-29)21-32(27(35)33(28)20-22-8-6-9-22)19-23-10-7-11-24(18-23)26(30)34/h3-5,7,10-13,18,22H,6,8-9,14-17,19-21H2,1-2H3,(H2,30,34)/t28-,29+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472120
PNG
(CIS-2-[4-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cn(CC(N)=O)nn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H37N7O2/c1-30(2)26(21-9-4-3-5-10-21)13-11-25(12-14-26)19-31(24(35)33(25)15-20-7-6-8-20)16-22-17-32(29-28-22)18-23(27)34/h3-5,9-10,17,20H,6-8,11-16,18-19H2,1-2H3,(H2,27,34)/t25-,26+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472058
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ncccn3)C(=O)N2CC2CCOC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H35N5O2/c1-29(2)26(22-7-4-3-5-8-22)12-10-25(11-13-26)20-30(18-23-27-14-6-15-28-23)24(32)31(25)17-21-9-16-33-19-21/h3-8,14-15,21H,9-13,16-20H2,1-2H3/t21?,25-,26+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471850
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(4-me...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(cc3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N3O3S/c1-30(2)29(25-10-5-4-6-11-25)18-16-28(17-19-29)22-31(27(33)32(28)21-23-8-7-9-23)20-24-12-14-26(15-13-24)36(3,34)35/h4-6,10-15,23H,7-9,16-22H2,1-3H3/t28-,29+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471985
PNG
(CIS-1-(3,3-Difluoro-cyclobutyl)-methyl]-8-dimethyl...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CC(F)(F)C3)C2=O)cc1
Show InChI InChI=1S/C29H37F2N3O2/c1-32(2)28(24-7-5-4-6-8-24)15-13-27(14-16-28)21-33(19-22-9-11-25(36-3)12-10-22)26(35)34(27)20-23-17-29(30,31)18-23/h4-12,23H,13-21H2,1-3H3/t27-,28+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472044
PNG
(CIS-8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-1...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CCC(C)C)C2=O)cc1
Show InChI InChI=1S/C29H41N3O2/c1-23(2)15-20-32-27(33)31(21-24-11-13-26(34-5)14-12-24)22-28(32)16-18-29(19-17-28,30(3)4)25-9-7-6-8-10-25/h6-14,23H,15-22H2,1-5H3/t28-,29+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472051
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccccn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N4O/c1-29(2)27(23-11-4-3-5-12-23)16-14-26(15-17-27)21-30(20-24-13-6-7-18-28-24)25(32)31(26)19-22-9-8-10-22/h3-7,11-13,18,22H,8-10,14-17,19-21H2,1-2H3/t26-,27+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472059
PNG
(CIS-1-[[8-Dimethylamino-3-[(4-methoxyphenyl)-methy...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(CCC3)C#N)C2=O)cc1
Show InChI InChI=1S/C30H38N4O2/c1-32(2)30(25-8-5-4-6-9-25)18-16-29(17-19-30)23-33(20-24-10-12-26(36-3)13-11-24)27(35)34(29)22-28(21-31)14-7-15-28/h4-6,8-13H,7,14-20,22-23H2,1-3H3/t29-,30+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472097
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)cc1
Show InChI InChI=1S/C29H39N3O2/c1-30(2)29(25-10-5-4-6-11-25)18-16-28(17-19-29)22-31(20-24-12-14-26(34-3)15-13-24)27(33)32(28)21-23-8-7-9-23/h4-6,10-15,23H,7-9,16-22H2,1-3H3/t28-,29+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472085
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(nc3)C(F)(F)F)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H35F3N4O/c1-33(2)27(23-9-4-3-5-10-23)15-13-26(14-16-27)20-34(25(36)35(26)19-21-7-6-8-21)18-22-11-12-24(32-17-22)28(29,30)31/h3-5,9-12,17,21H,6-8,13-16,18-20H2,1-2H3/t26-,27+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472083
PNG
(CIS-4-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(cc3)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H36N4O/c1-31(2)29(26-9-4-3-5-10-26)17-15-28(16-18-29)22-32(20-25-13-11-23(19-30)12-14-25)27(34)33(28)21-24-7-6-8-24/h3-5,9-14,24H,6-8,15-18,20-22H2,1-2H3/t28-,29+
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3.80n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472017
PNG
(CIS-1-(Cyclopentyl-methyl)-8-dimethylamino-3-[(4-m...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCCC3)C2=O)cc1
Show InChI InChI=1S/C30H41N3O2/c1-31(2)30(26-11-5-4-6-12-26)19-17-29(18-20-30)23-32(21-25-13-15-27(35-3)16-14-25)28(34)33(29)22-24-9-7-8-10-24/h4-6,11-16,24H,7-10,17-23H2,1-3H3/t29-,30+
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3.80n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472076
PNG
(CIS-8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-8...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCCO3)C2=O)cc1
Show InChI InChI=1S/C29H39N3O3/c1-30(2)29(24-8-5-4-6-9-24)17-15-28(16-18-29)22-31(20-23-11-13-25(34-3)14-12-23)27(33)32(28)21-26-10-7-19-35-26/h4-6,8-9,11-14,26H,7,10,15-22H2,1-3H3/t26?,28-,29+
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4n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472121
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[[1-(2...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cn(CCO)nn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H38N6O2/c1-29(2)26(22-9-4-3-5-10-22)13-11-25(12-14-26)20-30(18-23-19-31(15-16-33)28-27-23)24(34)32(25)17-21-7-6-8-21/h3-5,9-10,19,21,33H,6-8,11-18,20H2,1-2H3/t25-,26+
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4n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472095
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(CCc3ccccc3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H39N3O2/c1-30(2)29(25-12-7-4-8-13-25)19-17-27(18-20-29)22-31(21-14-24-10-5-3-6-11-24)26(33)32(27)23-28(34)15-9-16-28/h3-8,10-13,34H,9,14-23H2,1-2H3/t27-,29+
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GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471883
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(3-me...)
Show SMILES COc1cccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c1
Show InChI InChI=1S/C29H39N3O2/c1-30(2)29(25-12-5-4-6-13-25)17-15-28(16-18-29)22-31(20-24-11-8-14-26(19-24)34-3)27(33)32(28)21-23-9-7-10-23/h4-6,8,11-14,19,23H,7,9-10,15-18,20-22H2,1-3H3/t28-,29+
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4.30n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472034
PNG
(CIS-1-(Cyclobutyl-methyl)-8-methylamino-8-phenyl-3...)
Show SMILES CN[C@]1(CC[C@]2(CN(Cc3cccnc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H34N4O/c1-27-26(23-10-3-2-4-11-23)14-12-25(13-15-26)20-29(18-22-9-6-16-28-17-22)24(31)30(25)19-21-7-5-8-21/h2-4,6,9-11,16-17,21,27H,5,7-8,12-15,18-20H2,1H3/t25-,26+
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4.60n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472015
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES COc1cccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(O)CCC3)C2=O)c1
Show InChI InChI=1S/C29H39N3O3/c1-30(2)29(24-10-5-4-6-11-24)17-15-27(16-18-29)21-31(20-23-9-7-12-25(19-23)35-3)26(33)32(27)22-28(34)13-8-14-28/h4-7,9-12,19,34H,8,13-18,20-22H2,1-3H3/t27-,29+
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5.40n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472096
PNG
(CIS-2-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccccc3C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H36N4O/c1-31(2)29(26-13-4-3-5-14-26)17-15-28(16-18-29)22-32(21-25-12-7-6-11-24(25)19-30)27(34)33(28)20-23-9-8-10-23/h3-7,11-14,23H,8-10,15-18,20-22H2,1-2H3/t28-,29+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472001
PNG
(CIS-1-Butyl-8-dimethylamino-3-[(4-methoxyphenyl)-m...)
Show SMILES CCCCN1C(=O)N(Cc2ccc(OC)cc2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C28H39N3O2/c1-5-6-20-31-26(32)30(21-23-12-14-25(33-4)15-13-23)22-27(31)16-18-28(19-17-27,29(2)3)24-10-8-7-9-11-24/h7-15H,5-6,16-22H2,1-4H3/t27-,28+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472139
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(O)CCC2)C(C)(C)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C30H41N3O2/c1-27(2,24-12-7-5-8-13-24)32-22-28(33(26(32)34)23-29(35)16-11-17-29)18-20-30(21-19-28,31(3)4)25-14-9-6-10-15-25/h5-10,12-15,35H,11,16-23H2,1-4H3/t28-,30+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472012
PNG
(CIS-8-Dimethylamino-1-(1-hydroxy-cyclobutyl)-methy...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(O)CCC3)C2=O)cc1
Show InChI InChI=1S/C29H39N3O3/c1-30(2)29(24-8-5-4-6-9-24)18-16-27(17-19-29)21-31(20-23-10-12-25(35-3)13-11-23)26(33)32(27)22-28(34)14-7-15-28/h4-6,8-13,34H,7,14-22H2,1-3H3/t27-,29+
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9n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472061
PNG
(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclopentyl)-met...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(O)CCCC3)C2=O)cc1
Show InChI InChI=1S/C30H41N3O3/c1-31(2)30(25-9-5-4-6-10-25)19-17-28(18-20-30)22-32(21-24-11-13-26(36-3)14-12-24)27(34)33(28)23-29(35)15-7-8-16-29/h4-6,9-14,35H,7-8,15-23H2,1-3H3/t28-,30+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472065
PNG
(CIS-8-Dimethylamino-1-(3-methoxy-3-methyl-butyl)-3...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CCC(C)(C)OC)C2=O)cc1
Show InChI InChI=1S/C30H43N3O3/c1-28(2,36-6)20-21-33-27(34)32(22-24-12-14-26(35-5)15-13-24)23-29(33)16-18-30(19-17-29,31(3)4)25-10-8-7-9-11-25/h7-15H,16-23H2,1-6H3/t29-,30+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471997
PNG
(CIS-1-(Cyclobutyl-methyl)-3-[(4-methoxyphenyl)-met...)
Show SMILES CN[C@]1(CC[C@]2(CN(Cc3ccc(OC)cc3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H37N3O2/c1-29-28(24-9-4-3-5-10-24)17-15-27(16-18-28)21-30(19-23-11-13-25(33-2)14-12-23)26(32)31(27)20-22-7-6-8-22/h3-5,9-14,22,29H,6-8,15-21H2,1-2H3/t27-,28+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472024
PNG
(CIS-1-(Cyclobutyl-methyl)-3-[(3-methoxyphenyl)-met...)
Show SMILES CN[C@]1(CC[C@]2(CN(Cc3cccc(OC)c3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C28H37N3O2/c1-29-28(24-11-4-3-5-12-24)16-14-27(15-17-28)21-30(19-23-10-7-13-25(18-23)33-2)26(32)31(27)20-22-8-6-9-22/h3-5,7,10-13,18,22,29H,6,8-9,14-17,19-21H2,1-2H3/t27-,28+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472102
PNG
(CIS-8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-8...)
Show SMILES CCCN1C(=O)N(Cc2ccc(OC)cc2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C27H37N3O2/c1-5-19-30-25(31)29(20-22-11-13-24(32-4)14-12-22)21-26(30)15-17-27(18-16-26,28(2)3)23-9-7-6-8-10-23/h6-14H,5,15-21H2,1-4H3/t26-,27+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472010
PNG
(CIS-8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-1...)
Show SMILES COCCCN1C(=O)N(Cc2ccc(OC)cc2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C28H39N3O3/c1-29(2)28(24-9-6-5-7-10-24)17-15-27(16-18-28)22-30(26(32)31(27)19-8-20-33-3)21-23-11-13-25(34-4)14-12-23/h5-7,9-14H,8,15-22H2,1-4H3/t27-,28+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472047
PNG
(CIS-3-[8-Dimethylamino-3-[(4-methoxyphenyl)-methyl...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC(C)(C)C#N)C2=O)cc1
Show InChI InChI=1S/C29H38N4O2/c1-27(2,20-30)21-33-26(34)32(19-23-11-13-25(35-5)14-12-23)22-28(33)15-17-29(18-16-28,31(3)4)24-9-7-6-8-10-24/h6-14H,15-19,21-22H2,1-5H3/t28-,29+
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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472027
PNG
(CIS-3-[[1-(Cyclobutyl-methyl)-8-(ethyl-methyl-amin...)
Show SMILES CCN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C30H38N4O/c1-3-32(2)30(27-13-5-4-6-14-27)17-15-29(16-18-30)23-33(21-26-12-8-11-25(19-26)20-31)28(35)34(29)22-24-9-7-10-24/h4-6,8,11-14,19,24H,3,7,9-10,15-18,21-23H2,1-2H3/t29-,30+
PDB

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US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472117
PNG
(CIS-2-[4-[[8-Dimethylamino-1-[(1-hydroxy-cyclobuty...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cn(CC(N)=O)nn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C26H37N7O3/c1-30(2)26(20-7-4-3-5-8-20)13-11-24(12-14-26)18-31(15-21-16-32(29-28-21)17-22(27)34)23(35)33(24)19-25(36)9-6-10-25/h3-5,7-8,16,36H,6,9-15,17-19H2,1-2H3,(H2,27,34)/t24-,26+
PDB

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12.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472124
PNG
(CIS-2-[4-[[1-(Cyclobutyl-methyl)-8-methylamino-2-o...)
Show SMILES CN[C@]1(CC[C@]2(CN(Cc3cn(CC(N)=O)nn3)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35N7O2/c1-27-25(20-8-3-2-4-9-20)12-10-24(11-13-25)18-30(23(34)32(24)14-19-6-5-7-19)15-21-16-31(29-28-21)17-22(26)33/h2-4,8-9,16,19,27H,5-7,10-15,17-18H2,1H3,(H2,26,33)/t24-,25+
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13n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471983
PNG
(CIS-1-(2-Cyclobutyl-ethyl)-8-dimethylamino-3-[(4-m...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CCC3CCC3)C2=O)cc1
Show InChI InChI=1S/C30H41N3O2/c1-31(2)30(26-10-5-4-6-11-26)19-17-29(18-20-30)23-32(22-25-12-14-27(35-3)15-13-25)28(34)33(29)21-16-24-8-7-9-24/h4-6,10-15,24H,7-9,16-23H2,1-3H3/t29-,30+
PDB

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13.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472048
PNG
(CIS-8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-1...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(C)CCC3)C2=O)cc1
Show InChI InChI=1S/C30H41N3O2/c1-28(15-8-16-28)22-33-27(34)32(21-24-11-13-26(35-4)14-12-24)23-29(33)17-19-30(20-18-29,31(2)3)25-9-6-5-7-10-25/h5-7,9-14H,8,15-23H2,1-4H3/t29-,30+
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14n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472011
PNG
(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[[3-[2...)
Show SMILES COCCOCCOCCOCCOCCOCCOc1cccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c1
Show InChI InChI=1S/C41H63N3O8/c1-42(2)41(37-12-5-4-6-13-37)17-15-40(16-18-41)34-43(39(45)44(40)33-35-9-7-10-35)32-36-11-8-14-38(31-36)52-30-29-51-28-27-50-26-25-49-24-23-48-22-21-47-20-19-46-3/h4-6,8,11-14,31,35H,7,9-10,15-30,32-34H2,1-3H3/t40-,41+
PDB

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15.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472069
PNG
(CIS-3-[[8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H38N4O3/c1-31(2)29(24-10-4-3-5-11-24)16-14-27(15-17-29)20-32(19-22-8-6-9-23(18-22)25(30)34)26(35)33(27)21-28(36)12-7-13-28/h3-6,8-11,18,36H,7,12-17,19-21H2,1-2H3,(H2,30,34)/t27-,29+
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16.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472060
PNG
(CIS-3-[[1-[(5-Cyano-2-methoxy-phenyl)-methyl]-8-di...)
Show SMILES COc1ccc(cc1CN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(Cc2cc(ccc2OC)C#N)C1=O)C#N
Show InChI InChI=1S/C34H37N5O3/c1-37(2)34(29-8-6-5-7-9-29)16-14-33(15-17-34)24-38(22-27-18-25(20-35)10-12-30(27)41-3)32(40)39(33)23-28-19-26(21-36)11-13-31(28)42-4/h5-13,18-19H,14-17,22-24H2,1-4H3/t33-,34+
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16.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471992
PNG
(CIS-2-[8-Dimethylamino-3-[(4-methoxyphenyl)-methyl...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC(=O)OC(C)(C)C)C2=O)cc1
Show InChI InChI=1S/C30H41N3O4/c1-28(2,3)37-26(34)21-33-27(35)32(20-23-12-14-25(36-6)15-13-23)22-29(33)16-18-30(19-17-29,31(4)5)24-10-8-7-9-11-24/h7-15H,16-22H2,1-6H3/t29-,30+
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16.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472067
PNG
(CIS-2-[[8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccccc3C(N)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H38N4O3/c1-31(2)29(23-10-4-3-5-11-23)17-15-27(16-18-29)20-32(19-22-9-6-7-12-24(22)25(30)34)26(35)33(27)21-28(36)13-8-14-28/h3-7,9-12,36H,8,13-21H2,1-2H3,(H2,30,34)/t27-,29+
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17n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM471989
PNG
(CIS-4-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-ox...)
Show SMILES CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(cc3)C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1
Show InChI InChI=1S/C29H38N4O2/c1-31(2)29(25-9-4-3-5-10-25)17-15-28(16-18-29)21-32(27(35)33(28)20-22-7-6-8-22)19-23-11-13-24(14-12-23)26(30)34/h3-5,9-14,22H,6-8,15-21H2,1-2H3,(H2,30,34)/t28-,29+
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17.6n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM472037
PNG
(CIS-2-[8-Dimethylamino-3-[(4-methoxyphenyl)-methyl...)
Show SMILES COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC(=O)N(C)C)C2=O)cc1
Show InChI InChI=1S/C28H38N4O3/c1-29(2)25(33)20-32-26(34)31(19-22-11-13-24(35-5)14-12-22)21-27(32)15-17-28(18-16-27,30(3)4)23-9-7-6-8-10-23/h6-14H,15-21H2,1-5H3/t27-,28+
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18n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...


US Patent US10829480 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%