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Patent code US10842803

Compile Data Set for Download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473090
PNG
(6-(1H-indazol-6-yl)-N- {4H,6H,7H- pyrazolo[3,2- c]...)
Show SMILES C1Cn2nc(Nc3cc(cn4ccnc34)-c3ccc4cn[nH]c4c3)cc2CO1
Show InChI InChI=1S/C20H17N7O/c1-2-14-10-22-24-17(14)7-13(1)15-8-18(20-21-3-4-26(20)11-15)23-19-9-16-12-28-6-5-27(16)25-19/h1-4,7-11H,5-6,12H2,(H,22,24)(H,23,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473114
PNG
(2-hydroxy-1-(4-{6-[(6- {1H-pyrrolo[3,2- b]pyridin-...)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nc1
Show InChI InChI=1S/C25H24N8O2/c34-16-24(35)32-9-7-31(8-10-32)19-1-2-23(29-14-19)30-22-12-18(15-33-6-5-27-25(22)33)17-11-21-20(28-13-17)3-4-26-21/h1-6,11-15,26,34H,7-10,16H2,(H,29,30)
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n/an/a 2.60E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473125
PNG
(1-(2-(6-(1H-pyrrolo[3,2- b]pyridin-6- yl)imidazo[1...)
Show SMILES CC(=O)N1CCn2nc(Nc3cc(cn4ccnc34)-c3cnc4cc[nH]c4c3)cc2C1
Show InChI InChI=1S/C22H20N8O/c1-14(31)28-6-7-30-17(13-28)10-21(27-30)26-20-9-16(12-29-5-4-24-22(20)29)15-8-19-18(25-11-15)2-3-23-19/h2-5,8-12,23H,6-7,13H2,1H3,(H,26,27)
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n/an/a 2.80E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473118
PNG
(N-{5-methanesulfonyl- 4H,5H,6H,7H- pyrazolo[1,5-a]...)
Show SMILES CS(=O)(=O)N1CCn2nc(Nc3cc(cn4ccnc34)-c3cnc4cc[nH]c4c3)cc2C1
Show InChI InChI=1S/C21H20N8O2S/c1-32(30,31)28-6-7-29-16(13-28)10-20(26-29)25-19-9-15(12-27-5-4-23-21(19)27)14-8-18-17(24-11-14)2-3-22-18/h2-5,8-12,22H,6-7,13H2,1H3,(H,25,26)
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n/an/a 3.70E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473072
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-yl...)
Show SMILES COc1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1OC
Show InChI InChI=1S/C21H18N6O2/c1-28-18-5-6-19(25-21(18)29-2)24-17-10-15(12-27-8-7-22-20(17)27)13-3-4-14-11-23-26-16(14)9-13/h3-12H,1-2H3,(H,23,26)(H,24,25)
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n/an/a 3.80E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473108
PNG
(1-(4-{6-[(6-{1H- pyrrolo[3,2-b]pyridin-6- yl}imida...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nc1
Show InChI InChI=1S/C25H24N8O/c1-17(34)31-8-10-32(11-9-31)20-2-3-24(29-15-20)30-23-13-19(16-33-7-6-27-25(23)33)18-12-22-21(28-14-18)4-5-26-22/h2-7,12-16,26H,8-11H2,1H3,(H,29,30)
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n/an/a 4.29E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473102
PNG
(N-{4H,6H,7H- pyrazolo[3,2- c][1,4]oxazin-2-yl}-6- ...)
Show SMILES C1Cn2nc(Nc3cc(cn4ccnc34)-c3cnc4cc[nH]c4c3)cc2CO1
Show InChI InChI=1S/C20H17N7O/c1-2-21-17-7-13(10-23-16(1)17)14-8-18(20-22-3-4-26(20)11-14)24-19-9-15-12-28-6-5-27(15)25-19/h1-4,7-11,21H,5-6,12H2,(H,24,25)
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n/an/a 4.50E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473092
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-yl...)
Show SMILES C1CN(CCO1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nn1
Show InChI InChI=1S/C22H20N8O/c1-2-16-13-24-26-18(16)11-15(1)17-12-19(22-23-5-6-30(22)14-17)25-20-3-4-21(28-27-20)29-7-9-31-10-8-29/h1-6,11-14H,7-10H2,(H,24,26)(H,25,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473095
PNG
(1-(6-{[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-...)
Show SMILES OC1CN(C1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
Show InChI InChI=1S/C22H19N7O/c30-18-12-29(13-18)17-3-4-21(24-10-17)26-20-8-16(11-28-6-5-23-22(20)28)14-1-2-15-9-25-27-19(15)7-14/h1-11,18,30H,12-13H2,(H,24,26)(H,25,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473100
PNG
(US10842803, Structure TABLE 1.30 | [(2R)-4-(6-{[6-...)
Show SMILES OC[C@H]1CN(CCO1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
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n/an/a 5.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473088
PNG
(1-(6-{[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-...)
Show SMILES CC1(O)CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
Show InChI InChI=1S/C25H25N7O/c1-25(33)6-9-31(10-7-25)20-4-5-23(27-15-20)29-22-13-19(16-32-11-8-26-24(22)32)17-2-3-18-14-28-30-21(18)12-17/h2-5,8,11-16,33H,6-7,9-10H2,1H3,(H,27,29)(H,28,30)
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n/an/a 6.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473078
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-yl...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nn1C
Show InChI InChI=1S/C19H17N7/c1-12-7-18(24-25(12)2)22-17-9-15(11-26-6-5-20-19(17)26)13-3-4-14-10-21-23-16(14)8-13/h3-11H,1-2H3,(H,21,23)(H,22,24)
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n/an/a 6.20E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473082
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-yl...)
Show SMILES C1CN(CCO1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-13-26-28-20(17)11-16(1)18-12-21(23-24-5-6-30(23)15-18)27-22-4-3-19(14-25-22)29-7-9-31-10-8-29/h1-6,11-15H,7-10H2,(H,25,27)(H,26,28)
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n/an/a 6.60E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473127
PNG
(2-(6-(8-(6,7-dihydro-4H- pyrazolo[5,1- c][1,4]oxaz...)
Show SMILES OCCc1c[nH]c2cc(ccc12)-c1cc(Nc2cc3COCCn3n2)c2nccn2c1
Show InChI InChI=1S/C23H22N6O2/c30-7-3-16-12-25-20-9-15(1-2-19(16)20)17-10-21(23-24-4-5-28(23)13-17)26-22-11-18-14-31-8-6-29(18)27-22/h1-2,4-5,9-13,25,30H,3,6-8,14H2,(H,26,27)
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n/an/a 7.10E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473123
PNG
(N-(5-methyl-6-(1H- pyrrolo[3,2-b]pyridin-6- yl)imi...)
Show SMILES Cc1c(cc(Nc2cc3COCCn3n2)c2nccn12)-c1cnc2cc[nH]c2c1
Show InChI InChI=1S/C21H19N7O/c1-13-16(14-8-18-17(24-11-14)2-3-22-18)10-19(21-23-4-5-27(13)21)25-20-9-15-12-29-7-6-28(15)26-20/h2-5,8-11,22H,6-7,12H2,1H3,(H,25,26)
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n/an/a 7.70E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473098
PNG
(US10842803, Structure TABLE 1.28 | [(2S)-4-(6-{[6-...)
Show SMILES OC[C@@H]1CN(CCO1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
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n/an/a 8.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473097
PNG
(1-[(6-{[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin...)
Show SMILES CC(C)(O)COc1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
Show InChI InChI=1S/C23H22N6O2/c1-23(2,30)14-31-18-5-6-21(25-12-18)27-20-10-17(13-29-8-7-24-22(20)29)15-3-4-16-11-26-28-19(16)9-15/h3-13,30H,14H2,1-2H3,(H,25,27)(H,26,28)
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n/an/a 8.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473107
PNG
(2-[ethyl({6-[(6-{1H- pyrrolo[3,2-b]pyridin-6- yl}i...)
Show SMILES CCN(CCO)c1ccc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nc1
Show InChI InChI=1S/C23H23N7O/c1-2-29(9-10-31)18-3-4-22(27-14-18)28-21-12-17(15-30-8-7-25-23(21)30)16-11-20-19(26-13-16)5-6-24-20/h3-8,11-15,24,31H,2,9-10H2,1H3,(H,27,28)
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n/an/a 8.50E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473089
PNG
(2-[(6-{[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin...)
Show SMILES CN(CCO)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
Show InChI InChI=1S/C22H21N7O/c1-28(8-9-30)18-4-5-21(24-13-18)26-20-11-17(14-29-7-6-23-22(20)29)15-2-3-16-12-25-27-19(16)10-15/h2-7,10-14,30H,8-9H2,1H3,(H,24,26)(H,25,27)
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n/an/a 9.00E+3n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473117
PNG
(6-[8-({5- methanesulfonyl- 4H,5H,6H,7H- pyrazolo[1...)
Show SMILES CS(=O)(=O)N1CCn2nc(Nc3cc(cn4ccnc34)-c3ccc4CC(=O)Nc4c3)cc2C1
Show InChI InChI=1S/C22H21N7O3S/c1-33(31,32)28-6-7-29-17(13-28)11-20(26-29)24-19-9-16(12-27-5-4-23-22(19)27)14-2-3-15-10-21(30)25-18(15)8-14/h2-5,8-9,11-12H,6-7,10,13H2,1H3,(H,24,26)(H,25,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473105
PNG
(1,5-dimethyl-N-(6-{1H- pyrrolo[3,2-b]pyridin-6- yl...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nn1C
Show InChI InChI=1S/C19H17N7/c1-12-7-18(24-25(12)2)23-17-9-14(11-26-6-5-21-19(17)26)13-8-16-15(22-10-13)3-4-20-16/h3-11,20H,1-2H3,(H,23,24)
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n/an/a 1.05E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473124
PNG
(6-(8-(6,7-dihydro-4H- pyrazolo[5,1- c][1,4]oxazin-...)
Show SMILES Cc1c(cc(Nc2cc3COCCn3n2)c2nccn12)-c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C22H20N6O2/c1-13-17(14-2-3-15-9-21(29)25-18(15)8-14)11-19(22-23-4-5-27(13)22)24-20-10-16-12-30-7-6-28(16)26-20/h2-5,8,10-11H,6-7,9,12H2,1H3,(H,24,26)(H,25,29)
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n/an/a 1.08E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473122
PNG
(N-(5-(methoxymethyl)- 1-methyl-1H-pyrazol-3- yl)-6...)
Show SMILES COCc1cc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nn1C
Show InChI InChI=1S/C20H19N7O/c1-26-15(12-28-2)9-19(25-26)24-18-8-14(11-27-6-5-22-20(18)27)13-7-17-16(23-10-13)3-4-21-17/h3-11,21H,12H2,1-2H3,(H,24,25)
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n/an/a 1.09E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473120
PNG
(5-(4-ethylpiperazin-1- yl)-N-(6-{1H- pyrrolo[3,2-b...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nc1
Show InChI InChI=1S/C25H26N8/c1-2-31-9-11-32(12-10-31)20-3-4-24(29-16-20)30-23-14-19(17-33-8-7-27-25(23)33)18-13-22-21(28-15-18)5-6-26-22/h3-8,13-17,26H,2,9-12H2,1H3,(H,29,30)
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n/an/a 1.13E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473162
PNG
(5-(5-chloro-8-(5-(4- isopropylpiperazin-1- yl)pyri...)
Show SMILES COCCn1c2ccc(cc2[nH]c1=O)-c1cc(Nc2ccc(cn2)N2CCN(CC2)C(C)C)c2nccn2c1Cl
Show InChI InChI=1S/C29H33ClN8O2/c1-19(2)35-10-12-36(13-11-35)21-5-7-26(32-18-21)33-24-17-22(27(30)38-9-8-31-28(24)38)20-4-6-25-23(16-20)34-29(39)37(25)14-15-40-3/h4-9,16-19H,10-15H2,1-3H3,(H,32,33)(H,34,39)
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n/an/a 1.20E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473131
PNG
(N-(6-(1H-indazol-6-yl)- 5-methylimidazo[1,2- a]pyr...)
Show SMILES Cc1c(cc(Nc2cc3COCCn3n2)c2nccn12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C21H19N7O/c1-13-17(14-2-3-15-11-23-25-18(15)8-14)10-19(21-22-4-5-27(13)21)24-20-9-16-12-29-7-6-28(16)26-20/h2-5,8-11H,6-7,12H2,1H3,(H,23,25)(H,24,26)
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n/an/a 1.28E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473134
PNG
(N-(6-(1H-indol-6- yl)imidazo[1,2- a]pyridin-8-yl)-...)
Show SMILES C1Cn2nc(Nc3cc(cn4ccnc34)-c3ccc4cc[nH]c4c3)cc2CO1
Show InChI InChI=1S/C21H18N6O/c1-2-15(9-18-14(1)3-4-22-18)16-10-19(21-23-5-6-26(21)12-16)24-20-11-17-13-28-8-7-27(17)25-20/h1-6,9-12,22H,7-8,13H2,(H,24,25)
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n/an/a 1.30E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473091
PNG
(2-N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-...)
Show SMILES COCCN(C)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
Show InChI InChI=1S/C23H23N7O/c1-29(9-10-31-2)19-5-6-22(25-14-19)27-21-12-18(15-30-8-7-24-23(21)30)16-3-4-17-13-26-28-20(17)11-16/h3-8,11-15H,9-10H2,1-2H3,(H,25,27)(H,26,28)
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n/an/a 1.30E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473112
PNG
(6-(8-{[5- (hydroxymethyl)-1- methyl-1H-pyrazol-3- ...)
Show SMILES Cn1nc(Nc2cc(cn3ccnc23)-c2ccc3CC(=O)Nc3c2)cc1CO
Show InChI InChI=1S/C20H18N6O2/c1-25-15(11-27)9-18(24-25)22-17-7-14(10-26-5-4-21-20(17)26)12-2-3-13-8-19(28)23-16(13)6-12/h2-7,9-10,27H,8,11H2,1H3,(H,22,24)(H,23,28)
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n/an/a 1.30E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473076
PNG
(6-{8-[(5,6- dimethoxypyridin-2- yl)amino]imidazo[1...)
Show SMILES COc1ccc(Nc2cc(cn3ccnc23)-c2ccc3c(N)n[nH]c3c2)nc1OC
Show InChI InChI=1S/C21H19N7O2/c1-29-17-5-6-18(25-21(17)30-2)24-16-10-13(11-28-8-7-23-20(16)28)12-3-4-14-15(9-12)26-27-19(14)22/h3-11H,1-2H3,(H,24,25)(H3,22,26,27)
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n/an/a 1.33E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473158
PNG
(5-chloro-N-(5-(4- ethylpiperazin-1- yl)pyridin-2-y...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cn[nH]c4c3)c(Cl)n3ccnc23)nc1
Show InChI InChI=1S/C25H25ClN8/c1-2-32-9-11-33(12-10-32)19-5-6-23(28-16-19)30-22-14-20(24(26)34-8-7-27-25(22)34)17-3-4-18-15-29-31-21(18)13-17/h3-8,13-16H,2,9-12H2,1H3,(H,28,30)(H,29,31)
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n/an/a 1.40E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473094
PNG
(6-(8-{[6-(morpholin-4- yl)pyridazin-3- yl]amino}im...)
Show SMILES O=C1COc2ccc(cc2N1)-c1cc(Nc2ccc(nn2)N2CCOCC2)c2nccn2c1
Show InChI InChI=1S/C23H21N7O3/c31-22-14-33-19-2-1-15(11-17(19)26-22)16-12-18(23-24-5-6-30(23)13-16)25-20-3-4-21(28-27-20)29-7-9-32-10-8-29/h1-6,11-13H,7-10,14H2,(H,25,27)(H,26,31)
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n/an/a 1.50E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473099
PNG
(N-[6-(1H-indazol-6-yl)- 5-methylimidazo[1,2- a]pyr...)
Show SMILES Cc1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C24H23N7O/c1-16-20(17-2-3-18-14-27-29-21(18)12-17)13-22(24-25-6-7-31(16)24)28-23-5-4-19(15-26-23)30-8-10-32-11-9-30/h2-7,12-15H,8-11H2,1H3,(H,26,28)(H,27,29)
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n/an/a 1.50E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473161
PNG
(2-(6-(5-chloro-8-(5-(4- isopropylpiperazin-1- yl)p...)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2cc(-c3ccc4c(CCO)c[nH]c4c3)c(Cl)n3ccnc23)nc1
Show InChI InChI=1S/C29H32ClN7O/c1-19(2)35-10-12-36(13-11-35)22-4-6-27(33-18-22)34-26-16-24(28(30)37-9-8-31-29(26)37)20-3-5-23-21(7-14-38)17-32-25(23)15-20/h3-6,8-9,15-19,32,38H,7,10-14H2,1-2H3,(H,33,34)
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n/an/a 1.50E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473119
PNG
(6-(8-{[5-(4- acetylpiperazin-1- yl)pyridin-2- yl]a...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3CC(=O)Nc3c2)nc1
Show InChI InChI=1S/C26H25N7O2/c1-17(34)31-8-10-32(11-9-31)21-4-5-24(28-15-21)29-23-13-20(16-33-7-6-27-26(23)33)18-2-3-19-14-25(35)30-22(19)12-18/h2-7,12-13,15-16H,8-11,14H2,1H3,(H,28,29)(H,30,35)
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n/an/a 1.55E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473139
PNG
(N-(5-(4-ethylpiperazin- 1-yl)pyridin-2-yl)-6- (1H-...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cn[nH]c4c3)c(C)n3ccnc23)nc1
Show InChI InChI=1S/C26H28N8/c1-3-32-10-12-33(13-11-32)21-6-7-25(28-17-21)30-24-15-22(18(2)34-9-8-27-26(24)34)19-4-5-20-16-29-31-23(20)14-19/h4-9,14-17H,3,10-13H2,1-2H3,(H,28,30)(H,29,31)
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n/an/a 1.70E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473138
PNG
(2-(6-(8-(5- morpholinopyridin-2- ylamino)imidazo[1...)
Show SMILES OCCc1n[nH]c2cc(ccc12)-c1cc(Nc2ccc(cn2)N2CCOCC2)c2nccn2c1
Show InChI InChI=1S/C25H25N7O2/c33-10-5-21-20-3-1-17(13-22(20)30-29-21)18-14-23(25-26-6-7-32(25)16-18)28-24-4-2-19(15-27-24)31-8-11-34-12-9-31/h1-4,6-7,13-16,33H,5,8-12H2,(H,27,28)(H,29,30)
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n/an/a 1.70E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473159
PNG
(6-(5-chloro-8-(5-(4- isopropylpiperazin-1- yl)pyri...)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2cc(c(Cl)n3ccnc23)-c2ccc3CC(=O)Nc3c2)nc1
Show InChI InChI=1S/C27H28ClN7O/c1-17(2)33-9-11-34(12-10-33)20-5-6-24(30-16-20)31-23-15-21(26(28)35-8-7-29-27(23)35)18-3-4-19-14-25(36)32-22(19)13-18/h3-8,13,15-17H,9-12,14H2,1-2H3,(H,30,31)(H,32,36)
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n/an/a 1.70E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473113
PNG
(6-[8-({5-acetyl- 4H,5H,6H,7H- pyrazolo[1,5-a]pyraz...)
Show SMILES CC(=O)N1CCn2nc(Nc3cc(cn4ccnc34)-c3ccc4CC(=O)Nc4c3)cc2C1
Show InChI InChI=1S/C23H21N7O2/c1-14(31)28-6-7-30-18(13-28)11-21(27-30)25-20-9-17(12-29-5-4-24-23(20)29)15-2-3-16-10-22(32)26-19(16)8-15/h2-5,8-9,11-12H,6-7,10,13H2,1H3,(H,25,27)(H,26,32)
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n/an/a 1.80E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473074
PNG
(N-[6-(1,3-benzothiazol- 5-yl)imidazo[1,2- a]pyridi...)
Show SMILES COc1ccc(Nc2cc(cn3ccnc23)-c2ccc3scnc3c2)nc1OC
Show InChI InChI=1S/C21H17N5O2S/c1-27-17-4-6-19(25-21(17)28-2)24-16-10-14(11-26-8-7-22-20(16)26)13-3-5-18-15(9-13)23-12-29-18/h3-12H,1-2H3,(H,24,25)
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n/an/a 1.82E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473136
PNG
(6-(8-(5-(1-hydroxy-2- methylpropan-2- yl)pyridin-2...)
Show SMILES CC(C)(CO)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3CC(=O)Nc3c2)nc1
Show InChI InChI=1S/C24H23N5O2/c1-24(2,14-30)18-5-6-21(26-12-18)27-20-10-17(13-29-8-7-25-23(20)29)15-3-4-16-11-22(31)28-19(16)9-15/h3-10,12-13,30H,11,14H2,1-2H3,(H,26,27)(H,28,31)
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n/an/a 1.90E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473128
PNG
(5-(8-(5-(2- hydroxypropan-2-yl)-1- methyl-1H-pyraz...)
Show SMILES Cn1nc(Nc2cc(cn3ccnc23)-c2ccc3n(C)c(=O)[nH]c3c2)cc1C(C)(C)O
Show InChI InChI=1S/C22H23N7O2/c1-22(2,31)18-11-19(26-28(18)4)24-16-10-14(12-29-8-7-23-20(16)29)13-5-6-17-15(9-13)25-21(30)27(17)3/h5-12,31H,1-4H3,(H,24,26)(H,25,30)
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n/an/a 1.97E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473096
PNG
(1-(6-{[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-...)
Show SMILES CC1(O)CN(C1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)nc1
Show InChI InChI=1S/C23H21N7O/c1-23(31)13-30(14-23)18-4-5-21(25-11-18)27-20-9-17(12-29-7-6-24-22(20)29)15-2-3-16-10-26-28-19(16)8-15/h2-12,31H,13-14H2,1H3,(H,25,27)(H,26,28)
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n/an/a 2.00E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473116
PNG
(US10842803, Structure TABLE 1.46 | {1-methyl-3-[(6...)
Show SMILES Cn1nc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)cc1CO
Show InChI InChI=1S/C19H17N7O/c1-25-14(11-27)8-18(24-25)23-17-7-13(10-26-5-4-21-19(17)26)12-6-16-15(22-9-12)2-3-20-16/h2-10,20,27H,11H2,1H3,(H,23,24)
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n/an/a 2.08E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473135
PNG
(N-(5-cyclopropyl-1H- pyrazol-3-yl)-6-(1H- indazol-...)
Show SMILES C1CC1c1cc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)n[nH]1
Show InChI InChI=1S/C20H17N7/c1-2-12(1)17-9-19(26-25-17)23-18-8-15(11-27-6-5-21-20(18)27)13-3-4-14-10-22-24-16(14)7-13/h3-12H,1-2H2,(H,22,24)(H2,23,25,26)
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n/an/a 2.20E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473075
PNG
(7-{8-[(5,6- dimethoxypyridin-2- yl)amino]imidazo[1...)
Show SMILES COc1ccc(Nc2cc(cn3ccnc23)-c2ccc3ncc(O)nc3c2)nc1OC
Show InChI InChI=1S/C22H18N6O3/c1-30-18-5-6-19(27-22(18)31-2)25-17-10-14(12-28-8-7-23-21(17)28)13-3-4-15-16(9-13)26-20(29)11-24-15/h3-12H,1-2H3,(H,25,27)(H,26,29)
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n/an/a 2.24E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473087
PNG
(2-N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-...)
Show SMILES Nc1cccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)n1
Show InChI InChI=1S/C19H15N7/c20-17-2-1-3-18(24-17)23-16-9-14(11-26-7-6-21-19(16)26)12-4-5-13-10-22-25-15(13)8-12/h1-11H,(H,22,25)(H3,20,23,24)
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n/an/a 2.31E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473103
PNG
(1-methyl-N-(6-{1H- pyrrolo[3,2-b]pyridin-6- yl}imi...)
Show SMILES Cn1ccc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)n1
Show InChI InChI=1S/C18H15N7/c1-24-6-3-17(23-24)22-16-9-13(11-25-7-5-20-18(16)25)12-8-15-14(21-10-12)2-4-19-15/h2-11,19H,1H3,(H,22,23)
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n/an/a 2.32E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473077
PNG
(N-[6-(3,4-dihydro-2H- 1,4-benzoxazin-6- yl)imidazo...)
Show SMILES COc1ccc(Nc2cc(cn3ccnc23)-c2ccc3OCCNc3c2)nc1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-19-5-6-20(26-22(19)29-2)25-17-12-15(13-27-9-7-24-21(17)27)14-3-4-18-16(11-14)23-8-10-30-18/h3-7,9,11-13,23H,8,10H2,1-2H3,(H,25,26)
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n/an/a 2.37E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473121
PNG
(2-(6-(8-(5- morpholinopyridin-2- ylamino)imidazo[1...)
Show SMILES OCCc1c[nH]c2cc(ccc12)-c1cc(Nc2ccc(cn2)N2CCOCC2)c2nccn2c1
Show InChI InChI=1S/C26H26N6O2/c33-10-5-19-15-28-23-13-18(1-3-22(19)23)20-14-24(26-27-6-7-32(26)17-20)30-25-4-2-21(16-29-25)31-8-11-34-12-9-31/h1-4,6-7,13-17,28,33H,5,8-12H2,(H,29,30)
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n/an/a 2.39E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473110
PNG
(1-{4-[6-({6-[3-(2- hydroxyethyl)-1H-indol- 6-yl]im...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3c(CCO)c[nH]c3c2)nc1
Show InChI InChI=1S/C28H29N7O2/c1-19(37)33-9-11-34(12-10-33)23-3-5-27(31-17-23)32-26-15-22(18-35-8-7-29-28(26)35)20-2-4-24-21(6-13-36)16-30-25(24)14-20/h2-5,7-8,14-18,30,36H,6,9-13H2,1H3,(H,31,32)
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n/an/a 2.50E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473106
PNG
(1-(2-hydroxyethyl)-5-(8- {[5-(morpholin-4- yl)pyri...)
Show SMILES OCCn1c2ccc(cc2[nH]c1=O)-c1cc(Nc2ccc(cn2)N2CCOCC2)c2nccn2c1
Show InChI InChI=1S/C25H25N7O3/c33-10-7-32-22-3-1-17(13-20(22)29-25(32)34)18-14-21(24-26-5-6-31(24)16-18)28-23-4-2-19(15-27-23)30-8-11-35-12-9-30/h1-6,13-16,33H,7-12H2,(H,27,28)(H,29,34)
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n/an/a 2.52E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473132
PNG
(6-(8-(5-cyclopropyl-1H- pyrazol-3- ylamino)imidazo...)
Show SMILES O=C1Cc2ccc(cc2N1)-c1cc(Nc2cc([nH]n2)C2CC2)c2nccn2c1
Show InChI InChI=1S/C21H18N6O/c28-20-9-14-4-3-13(7-16(14)24-20)15-8-18(21-22-5-6-27(21)11-15)23-19-10-17(25-26-19)12-1-2-12/h3-8,10-12H,1-2,9H2,(H,24,28)(H2,23,25,26)
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n/an/a 2.60E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473166
PNG
(N-(6-(1H-pyrazolo[4,3- b]pyridin-6- yl)imidazo[1,2...)
Show SMILES CN1CCn2nc(Nc3cc(cn4ccnc34)-c3cnc4cn[nH]c4c3)cc2C1
Show InChI InChI=1S/C20H19N9/c1-27-4-5-29-15(12-27)8-19(26-29)24-17-7-14(11-28-3-2-21-20(17)28)13-6-16-18(22-9-13)10-23-25-16/h2-3,6-11H,4-5,12H2,1H3,(H,23,25)(H,24,26)
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n/an/a 2.64E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473155
PNG
(5-chloro-6-(1H-indazol- 6-yl)-N-(5-(4- isopropylpi...)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cn[nH]c4c3)c(Cl)n3ccnc23)nc1
Show InChI InChI=1S/C26H27ClN8/c1-17(2)33-9-11-34(12-10-33)20-5-6-24(29-16-20)31-23-14-21(25(27)35-8-7-28-26(23)35)18-3-4-19-15-30-32-22(19)13-18/h3-8,13-17H,9-12H2,1-2H3,(H,29,31)(H,30,32)
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n/an/a 3.20E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473133
PNG
(6-(8-(6,7-dihydro-4H- pyrazolo[5,1- c][1,4]oxazin-...)
Show SMILES O=C1Cc2ccc(cc2N1)-c1cc(Nc2cc3COCCn3n2)c2nccn2c1
Show InChI InChI=1S/C21H18N6O2/c28-20-9-14-2-1-13(7-17(14)24-20)15-8-18(21-22-3-4-26(21)11-15)23-19-10-16-12-29-6-5-27(16)25-19/h1-4,7-8,10-11H,5-6,9,12H2,(H,23,25)(H,24,28)
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n/an/a 3.40E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473085
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-yl...)
Show SMILES Cn1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)n1
Show InChI InChI=1S/C18H15N7/c1-24-6-4-17(23-24)21-16-9-14(11-25-7-5-19-18(16)25)12-2-3-13-10-20-22-15(13)8-12/h2-11H,1H3,(H,20,22)(H,21,23)
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n/an/a 3.55E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473104
PNG
(N-(5-methyl-6-{1H- pyrrolo[3,2-b]pyridin-6- yl}imi...)
Show SMILES Cc1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1cnc2cc[nH]c2c1
Show InChI InChI=1S/C24H23N7O/c1-16-19(17-12-21-20(27-14-17)4-5-25-21)13-22(24-26-6-7-31(16)24)29-23-3-2-18(15-28-23)30-8-10-32-11-9-30/h2-7,12-15,25H,8-11H2,1H3,(H,28,29)
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n/an/a 3.80E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473093
PNG
(1-ethyl-N-[6-(1H- indazol-6- yl)imidazo[1,2- a]pyr...)
Show SMILES CCn1nc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1C
Show InChI InChI=1S/C20H19N7/c1-3-27-13(2)8-19(25-27)23-18-10-16(12-26-7-6-21-20(18)26)14-4-5-15-11-22-24-17(15)9-14/h4-12H,3H2,1-2H3,(H,22,24)(H,23,25)
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n/an/a 3.90E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473083
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-yl...)
Show SMILES COc1nccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)n1
Show InChI InChI=1S/C19H15N7O/c1-27-19-21-5-4-17(24-19)23-16-9-14(11-26-7-6-20-18(16)26)12-2-3-13-10-22-25-15(13)8-12/h2-11H,1H3,(H,22,25)(H,21,23,24)
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n/an/a 4.05E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473126
PNG
(6-(8-(5-(2- hydroxypropan-2-yl)-1- methyl-1H-pyraz...)
Show SMILES Cn1nc(Nc2cc(cn3ccnc23)-c2ccc3CC(=O)Nc3c2)cc1C(C)(C)O
Show InChI InChI=1S/C22H22N6O2/c1-22(2,30)18-11-19(26-27(18)3)24-17-9-15(12-28-7-6-23-21(17)28)13-4-5-14-10-20(29)25-16(14)8-13/h4-9,11-12,30H,10H2,1-3H3,(H,24,26)(H,25,29)
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n/an/a 4.15E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473140
PNG
(N-(5-(4-ethylpiperazin- 1-yl)pyridin-2-yl)-6- (1H-...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cc[nH]c4c3)c(C)n3ccnc23)nc1
Show InChI InChI=1S/C27H29N7/c1-3-32-12-14-33(15-13-32)22-6-7-26(30-18-22)31-25-17-23(19(2)34-11-10-29-27(25)34)21-5-4-20-8-9-28-24(20)16-21/h4-11,16-18,28H,3,12-15H2,1-2H3,(H,30,31)
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n/an/a 4.20E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473115
PNG
(6-(8-{[1-(2- hydroxyethyl)-5-methyl- 1H-pyrazol-3-...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2ccc3CC(=O)Nc3c2)nn1CCO
Show InChI InChI=1S/C21H20N6O2/c1-13-8-19(25-27(13)6-7-28)23-18-10-16(12-26-5-4-22-21(18)26)14-2-3-15-11-20(29)24-17(15)9-14/h2-5,8-10,12,28H,6-7,11H2,1H3,(H,23,25)(H,24,29)
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n/an/a 4.32E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473170
PNG
(US10842803, Structure TABLE 1.100 | methyl 6-(1H-i...)
Show SMILES COC(=O)c1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C25H23N7O3/c1-34-25(33)23-19(16-2-3-17-14-28-30-20(17)12-16)13-21(24-26-6-7-32(23)24)29-22-5-4-18(15-27-22)31-8-10-35-11-9-31/h2-7,12-15H,8-11H2,1H3,(H,27,29)(H,28,30)
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n/an/a 4.33E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473129
PNG
(2-(3-(6-(1H-pyrrolo[3,2- b]pyridin-6- yl)imidazo[1...)
Show SMILES Cn1nc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)cc1C(C)(C)O
Show InChI InChI=1S/C21H21N7O/c1-21(2,29)18-10-19(26-27(18)3)25-17-9-14(12-28-7-6-23-20(17)28)13-8-16-15(24-11-13)4-5-22-16/h4-12,22,29H,1-3H3,(H,25,26)
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n/an/a 4.48E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473164
PNG
(N-(6-(1H-indol-6- yl)imidazo[1,2- a]pyridin-8-yl)-...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2ccc3cc[nH]c3c2)no1
Show InChI InChI=1S/C19H15N5O/c1-12-8-18(23-25-12)22-17-10-15(11-24-7-6-21-19(17)24)14-3-2-13-4-5-20-16(13)9-14/h2-11,20H,1H3,(H,22,23)
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n/an/a 4.90E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473130
PNG
(N-(6-(3,4-dihydro-2H- benzo[b][1,4]oxazin-6- yl)im...)
Show SMILES C1COc2ccc(cc2N1)-c1cc(Nc2cc3COCCn3n2)c2nccn2c1
Show InChI InChI=1S/C21H20N6O2/c1-2-19-17(22-4-7-29-19)9-14(1)15-10-18(21-23-3-5-26(21)12-15)24-20-11-16-13-28-8-6-27(16)25-20/h1-3,5,9-12,22H,4,6-8,13H2,(H,24,25)
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n/an/a 4.93E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473111
PNG
(2-{5-methyl-3-[(6-{1H- pyrrolo[3,2-b]pyridin-6- yl...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nn1CCO
Show InChI InChI=1S/C20H19N7O/c1-13-8-19(25-27(13)6-7-28)24-18-10-15(12-26-5-4-22-20(18)26)14-9-17-16(23-11-14)2-3-21-17/h2-5,8-12,21,28H,6-7H2,1H3,(H,24,25)
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n/an/a 5.40E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473147
PNG
(5-(8-(5-(4- ethylpiperazin-1- yl)pyridin-2-ylamino...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(c(C)n3ccnc23)-c2ccc3n(CCOC)c(=O)[nH]c3c2)nc1
Show InChI InChI=1S/C29H34N8O2/c1-4-34-11-13-35(14-12-34)22-6-8-27(31-19-22)32-25-18-23(20(2)36-10-9-30-28(25)36)21-5-7-26-24(17-21)33-29(38)37(26)15-16-39-3/h5-10,17-19H,4,11-16H2,1-3H3,(H,31,32)(H,33,38)
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n/an/a 5.50E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473165
PNG
(5-fluoro-6-(1H-indazol- 6-yl)-N-(5-(4- isopropylpi...)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cn[nH]c4c3)c(F)n3ccnc23)nc1
Show InChI InChI=1S/C26H27FN8/c1-17(2)33-9-11-34(12-10-33)20-5-6-24(29-16-20)31-23-14-21(25(27)35-8-7-28-26(23)35)18-3-4-19-15-30-32-22(19)13-18/h3-8,13-17H,9-12H2,1-2H3,(H,29,31)(H,30,32)
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n/an/a 6.80E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473141
PNG
(6-(8-(5-(4- ethylpiperazin-1- yl)pyridin-2-ylamino...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(c(C)n3ccnc23)-c2ccc3CC(=O)Nc3c2)nc1
Show InChI InChI=1S/C27H29N7O/c1-3-32-10-12-33(13-11-32)21-6-7-25(29-17-21)30-24-16-22(18(2)34-9-8-28-27(24)34)19-4-5-20-15-26(35)31-23(20)14-19/h4-9,14,16-17H,3,10-13,15H2,1-2H3,(H,29,30)(H,31,35)
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n/an/a 7.10E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473163
PNG
(N-(6-(1H-indol-6- yl)imidazo[1,2- a]pyridin-8-yl)-...)
Show SMILES CN1CCc2nc(Nc3cc(cn4ccnc34)-c3ccc4cc[nH]c4c3)sc2C1
Show InChI InChI=1S/C22H20N6S/c1-27-8-5-17-20(13-27)29-22(25-17)26-19-11-16(12-28-9-7-24-21(19)28)15-3-2-14-4-6-23-18(14)10-15/h2-4,6-7,9-12,23H,5,8,13H2,1H3,(H,25,26)
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n/an/a 7.20E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473168
PNG
((6-(1H-indazol-6-yl)-8- (5-morpholinopyridin-2- yl...)
Show SMILES OCc1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C24H23N7O2/c32-15-22-19(16-1-2-17-13-27-29-20(17)11-16)12-21(24-25-5-6-31(22)24)28-23-4-3-18(14-26-23)30-7-9-33-10-8-30/h1-6,11-14,32H,7-10,15H2,(H,26,28)(H,27,29)
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n/an/a 7.55E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473154
PNG
(6-(5-chloro-8-(5-(4- ethylpiperazin-1- yl)pyridin-...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(c(Cl)n3ccnc23)-c2ccc3CC(=O)Nc3c2)nc1
Show InChI InChI=1S/C26H26ClN7O/c1-2-32-9-11-33(12-10-32)19-5-6-23(29-16-19)30-22-15-20(25(27)34-8-7-28-26(22)34)17-3-4-18-14-24(35)31-21(18)13-17/h3-8,13,15-16H,2,9-12,14H2,1H3,(H,29,30)(H,31,35)
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n/an/a 8.00E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473137
PNG
(2-(6-(8-(5-(4- ethylpiperazin-1- yl)pyridin-2- yla...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3c(CCO)n[nH]c3c2)nc1
Show InChI InChI=1S/C27H30N8O/c1-2-33-10-12-34(13-11-33)21-4-6-26(29-17-21)30-25-16-20(18-35-9-8-28-27(25)35)19-3-5-22-23(7-14-36)31-32-24(22)15-19/h3-6,8-9,15-18,36H,2,7,10-14H2,1H3,(H,29,30)(H,31,32)
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n/an/a 9.20E+4n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473146
PNG
(6-(1H-indazol-6-yl)-5- methyl-N-(5-(piperazin- 1-y...)
Show SMILES Cc1c(cc(Nc2ccc(cn2)N2CCNCC2)c2nccn12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C24H24N8/c1-16-20(17-2-3-18-14-28-30-21(18)12-17)13-22(24-26-8-11-32(16)24)29-23-5-4-19(15-27-23)31-9-6-25-7-10-31/h2-5,8,11-15,25H,6-7,9-10H2,1H3,(H,27,29)(H,28,30)
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n/an/a 1.28E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473109
PNG
(2-[4-({6-[3-(2- hydroxyethyl)-1H-indol- 6-yl]imida...)
Show SMILES CC(C)(CO)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3c(CCO)c[nH]c3c2)cc1
Show InChI InChI=1S/C27H28N4O2/c1-27(2,17-33)21-4-6-22(7-5-21)30-25-14-20(16-31-11-10-28-26(25)31)18-3-8-23-19(9-12-32)15-29-24(23)13-18/h3-8,10-11,13-16,29-30,32-33H,9,12,17H2,1-2H3
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n/an/a 1.38E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473084
PNG
(N-[6-(3,4-dihydro-2H- 1,4-benzoxazin-6- yl)imidazo...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2ccc3OCCNc3c2)nn1C
Show InChI InChI=1S/C20H20N6O/c1-13-9-19(24-25(13)2)23-17-11-15(12-26-7-5-22-20(17)26)14-3-4-18-16(10-14)21-6-8-27-18/h3-5,7,9-12,21H,6,8H2,1-2H3,(H,23,24)
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n/an/a 1.54E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473144
PNG
(5-methyl-N-(5- morpholinopyridin-2- yl)-6-(1H-pyrr...)
Show SMILES Cc1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C24H23N7O/c1-16-20(18-12-17-4-5-25-23(17)28-14-18)13-21(24-26-6-7-31(16)24)29-22-3-2-19(15-27-22)30-8-10-32-11-9-30/h2-7,12-15H,8-11H2,1H3,(H,25,28)(H,27,29)
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n/an/a 1.66E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473080
PNG
(6-{8-[(1-ethyl-1H- pyrazol-3- yl)amino]imidazo[1,2...)
Show SMILES CCn1ccc(Nc2cc(cn3ccnc23)-c2ccc3nc(N)ncc3c2)n1
Show InChI InChI=1S/C20H18N8/c1-2-28-7-5-18(26-28)24-17-10-15(12-27-8-6-22-19(17)27)13-3-4-16-14(9-13)11-23-20(21)25-16/h3-12H,2H2,1H3,(H,24,26)(H2,21,23,25)
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n/an/a 1.71E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473081
PNG
(1,5-dimethyl-N-[6-(1- methyl-1H-1,3- benzodiazol-6...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2ccc3ncn(C)c3c2)nn1C
Show InChI InChI=1S/C20H19N7/c1-13-8-19(24-26(13)3)23-17-9-15(11-27-7-6-21-20(17)27)14-4-5-16-18(10-14)25(2)12-22-16/h4-12H,1-3H3,(H,23,24)
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n/an/a 1.82E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473086
PNG
(1,5-dimethyl-N-[6-(1- methyl-1H-1,3- benzodiazol-5...)
Show SMILES Cc1cc(Nc2cc(cn3ccnc23)-c2ccc3n(C)cnc3c2)nn1C
Show InChI InChI=1S/C20H19N7/c1-13-8-19(24-26(13)3)23-17-10-15(11-27-7-6-21-20(17)27)14-4-5-18-16(9-14)22-12-25(18)2/h4-12H,1-3H3,(H,23,24)
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n/an/a 1.88E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473156
PNG
(2-(6-(5-chloro-8-(5-(4- ethylpiperazin-1- yl)pyrid...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4c(CCO)c[nH]c4c3)c(Cl)n3ccnc23)nc1
Show InChI InChI=1S/C28H30ClN7O/c1-2-34-10-12-35(13-11-34)21-4-6-26(32-18-21)33-25-16-23(27(29)36-9-8-30-28(25)36)19-3-5-22-20(7-14-37)17-31-24(22)15-19/h3-6,8-9,15-18,31,37H,2,7,10-14H2,1H3,(H,32,33)
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n/an/a 2.15E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473160
PNG
(2-(6-(5-chloro-8-(5-(4- isopropylpiperazin-1- yl)p...)
Show SMILES CC(C)N1CCN(CC1)c1ccc(Nc2cc(-c3ccc4c(CCO)cn(C)c4c3)c(Cl)n3ccnc23)nc1
Show InChI InChI=1S/C30H34ClN7O/c1-20(2)36-11-13-37(14-12-36)23-5-7-28(33-18-23)34-26-17-25(29(31)38-10-9-32-30(26)38)21-4-6-24-22(8-15-39)19-35(3)27(24)16-21/h4-7,9-10,16-20,39H,8,11-15H2,1-3H3,(H,33,34)
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n/an/a 2.18E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473149
PNG
(5-ethyl-N-(5-(4- ethylpiperazin-1- yl)pyridin-2-yl...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cn[nH]c4c3)c(CC)n3ccnc23)nc1
Show InChI InChI=1S/C27H30N8/c1-3-25-22(19-5-6-20-17-30-32-23(20)15-19)16-24(27-28-9-10-35(25)27)31-26-8-7-21(18-29-26)34-13-11-33(4-2)12-14-34/h5-10,15-18H,3-4,11-14H2,1-2H3,(H,29,31)(H,30,32)
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n/an/a 2.52E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473153
PNG
(5-chloro-N-(5-(4- ethylpiperazin-1- yl)pyridin-2-y...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cc[nH]c4c3)c(Cl)n3ccnc23)nc1
Show InChI InChI=1S/C26H26ClN7/c1-2-32-11-13-33(14-12-32)20-5-6-24(30-17-20)31-23-16-21(25(27)34-10-9-29-26(23)34)19-4-3-18-7-8-28-22(18)15-19/h3-10,15-17,28H,2,11-14H2,1H3,(H,30,31)
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n/an/a 2.71E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473150
PNG
(5-ethyl-N-(5-(4- ethylpiperazin-1- yl)pyridin-2-yl...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cc[nH]c4c3)c(CC)n3ccnc23)nc1
Show InChI InChI=1S/C28H31N7/c1-3-26-23(21-6-5-20-9-10-29-24(20)17-21)18-25(28-30-11-12-35(26)28)32-27-8-7-22(19-31-27)34-15-13-33(4-2)14-16-34/h5-12,17-19,29H,3-4,13-16H2,1-2H3,(H,31,32)
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n/an/a 2.72E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473157
PNG
(2-(6-(5-chloro-8-(5-(4- ethylpiperazin-1- yl)pyrid...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4c(CCO)cn(C)c4c3)c(Cl)n3ccnc23)nc1
Show InChI InChI=1S/C29H32ClN7O/c1-3-35-11-13-36(14-12-35)22-5-7-27(32-18-22)33-25-17-24(28(30)37-10-9-31-29(25)37)20-4-6-23-21(8-15-38)19-34(2)26(23)16-20/h4-7,9-10,16-19,38H,3,8,11-15H2,1-2H3,(H,32,33)
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n/an/a 2.78E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473101
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8-yl...)
Show SMILES C1CN(CCO1)c1nc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cs1
Show InChI InChI=1S/C21H19N7OS/c1-2-15-11-23-26-17(15)9-14(1)16-10-18(20-22-3-4-28(20)12-16)24-19-13-30-21(25-19)27-5-7-29-8-6-27/h1-4,9-13,24H,5-8H2,(H,23,26)
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n/an/a 2.91E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473073
PNG
(N-[6-(1H-indazol-6- yl)imidazo[1,2- a]pyridin-8- y...)
Show SMILES N(c1ccncn1)c1cc(cn2ccnc12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C18H13N7/c1-2-13-9-22-24-15(13)7-12(1)14-8-16(18-20-5-6-25(18)10-14)23-17-3-4-19-11-21-17/h1-11H,(H,22,24)(H,19,21,23)
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n/an/a 2.97E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473142
PNG
(2-(6-(8-(5-(4- ethylpiperazin-1- yl)pyridin-2-ylam...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(c(C)n3ccnc23)-c2ccc3c(CCO)c[nH]c3c2)nc1
Show InChI InChI=1S/C29H33N7O/c1-3-34-11-13-35(14-12-34)23-5-7-28(32-19-23)33-27-17-25(20(2)36-10-9-30-29(27)36)21-4-6-24-22(8-15-37)18-31-26(24)16-21/h4-7,9-10,16-19,31,37H,3,8,11-15H2,1-2H3,(H,32,33)
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n/an/a 3.01E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473152
PNG
(2-(1-methyl-6-(5- methyl-8-(5- morpholinopyridin-2...)
Show SMILES Cc1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1ccc2c(CCO)cn(C)c2c1
Show InChI InChI=1S/C28H30N6O2/c1-19-24(20-3-5-23-21(7-12-35)18-32(2)26(23)15-20)16-25(28-29-8-9-34(19)28)31-27-6-4-22(17-30-27)33-10-13-36-14-11-33/h3-6,8-9,15-18,35H,7,10-14H2,1-2H3,(H,30,31)
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n/an/a 3.20E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473148
PNG
(N-(5-(4-ethylpiperazin- 1-yl)pyridin-2-yl)-5- meth...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cc(C)[nH]c4c3)c(C)n3ccnc23)nc1
Show InChI InChI=1S/C28H31N7/c1-4-33-11-13-34(14-12-33)23-7-8-27(30-18-23)32-26-17-24(20(3)35-10-9-29-28(26)35)21-5-6-22-15-19(2)31-25(22)16-21/h5-10,15-18,31H,4,11-14H2,1-3H3,(H,30,32)
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n/an/a 4.23E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473151
PNG
(6-(5-ethyl-8-(5-(4- ethylpiperazin-1- yl)pyridin-2...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(c(CC)n3ccnc23)-c2ccc3CC(=O)Nc3c2)nc1
Show InChI InChI=1S/C28H31N7O/c1-3-25-22(19-5-6-20-16-27(36)32-23(20)15-19)17-24(28-29-9-10-35(25)28)31-26-8-7-21(18-30-26)34-13-11-33(4-2)12-14-34/h5-10,15,17-18H,3-4,11-14,16H2,1-2H3,(H,30,31)(H,32,36)
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UniChem
US Patent
n/an/a 5.32E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473079
PNG
(6-{8-[(1-ethyl-1H- pyrazol-3- yl)amino]imidazo[1,2...)
Show SMILES CCn1ccc(Nc2cc(cn3ccnc23)-c2ccc3OCC(=O)Nc3c2)n1
Show InChI InChI=1S/C20H18N6O2/c1-2-26-7-5-18(24-26)22-16-10-14(11-25-8-6-21-20(16)25)13-3-4-17-15(9-13)23-19(27)12-28-17/h3-11H,2,12H2,1H3,(H,22,24)(H,23,27)
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UniChem
US Patent
n/an/a 5.48E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473167
PNG
(6-(1H-indazol-6-yl)-8- (5-morpholinopyridin-2- yla...)
Show SMILES NC(=O)c1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C24H22N8O2/c25-23(33)22-18(15-1-2-16-13-28-30-19(16)11-15)12-20(24-26-5-6-32(22)24)29-21-4-3-17(14-27-21)31-7-9-34-10-8-31/h1-6,11-14H,7-10H2,(H2,25,33)(H,27,29)(H,28,30)
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US Patent
n/an/a 5.69E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473143
PNG
(6-(8-(5-(4- ethylpiperazin-1- yl)pyridin-2-ylamino...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4c(c[nH]c4c3)C(=O)NC)c(C)n3ccnc23)nc1
Show InChI InChI=1S/C29H32N8O/c1-4-35-11-13-36(14-12-35)21-6-8-27(33-17-21)34-26-16-23(19(2)37-10-9-31-28(26)37)20-5-7-22-24(29(38)30-3)18-32-25(22)15-20/h5-10,15-18,32H,4,11-14H2,1-3H3,(H,30,38)(H,33,34)
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US Patent
n/an/a 8.83E+5n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473145
PNG
(1-methyl-6-(5-methyl-8- (5-morpholinopyridin-2- yl...)
Show SMILES CN1C(=O)Cc2ccc(cc12)-c1cc(Nc2ccc(cn2)N2CCOCC2)c2nccn2c1C
Show InChI InChI=1S/C26H26N6O2/c1-17-21(18-3-4-19-14-25(33)30(2)23(19)13-18)15-22(26-27-7-8-32(17)26)29-24-6-5-20(16-28-24)31-9-11-34-12-10-31/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,28,29)
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n/an/a 1.03E+6n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473071
PNG
(N-(3,4- dimethoxyphenyl)-6- (1H-indazol-6- yl)imid...)
Show SMILES COc1ccc(Nc2cc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1OC
Show InChI InChI=1S/C22H19N5O2/c1-28-20-6-5-17(11-21(20)29-2)25-19-10-16(13-27-8-7-23-22(19)27)14-3-4-15-12-24-26-18(15)9-14/h3-13,25H,1-2H3,(H,24,26)
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n/an/a 1.05E+6n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM473169
PNG
(6-(1H-indazol-6-yl)-8- (5-morpholinopyridin-2- yla...)
Show SMILES OC(=O)c1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C24H21N7O3/c32-24(33)22-18(15-1-2-16-13-27-29-19(16)11-15)12-20(23-25-5-6-31(22)23)28-21-4-3-17(14-26-21)30-7-9-34-10-8-30/h1-6,11-14H,7-10H2,(H,26,28)(H,27,29)(H,32,33)
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US Patent
n/an/a 4.23E+6n/an/an/an/an/an/a



KRONOS BIO, INC.

US Patent


Assay Description
A master mix minus Syk enzyme is prepared containing 1X Cell Signaling kinase buffer (25 mM Tris-HCl, pH 7.5, 5 mM beta-glycerophosphate, 2 mM dithio...


US Patent US10842803 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%