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TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  0.460nMAssay Description:Inhibition of activated Protein C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  0.460nMAssay Description:Inhibition of activated protein kinase C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514081(CHEMBL4471466)
Affinity DataKi:  0.460nMAssay Description:Inhibition of activated Protein C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380619(CHEMBL2016865)
Affinity DataKi:  0.610nMAssay Description:Inhibition of activated protein C by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human activated protein C using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380620(CHEMBL2016866)
Affinity DataKi:  5.10nMAssay Description:Inhibition of activated protein C by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM47178(US8598206, Table 6, 12 | BDBM108103)
Affinity DataKi:  27nMAssay Description:Inhibition of human aPC was determined by the method described in [0092]-[0098] using human activated protein C from Enzyme Research Laboratories at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2014
Entry Details
US Patent

TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50205841(CHEMBL3898956)
Affinity DataKi:  39nMAssay Description:Inhibition of activated protein C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50425661(CHEMBL2315240)
Affinity DataKi:  39nMAssay Description:Inhibition of human activated protein C using H-D-Lys(Cbz)-Pro-Arg-pNA as substrate after 5 to 10 mins by micro plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447515(CHEMBL3115901)
Affinity DataKi:  40nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50098596(CHEMBL3594313)
Affinity DataKi:  41nMAssay Description:Inhibition of human APC measured for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380616(CHEMBL2016869)
Affinity DataKi:  48nMAssay Description:Inhibition of activated protein C by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108101(US8598206, Table 6, 10)
Affinity DataKi:  60nMAssay Description:Inhibition of human aPC was determined by the method described in [0092]-[0098] using human activated protein C from Enzyme Research Laboratories at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2014
Entry Details
US Patent

TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50192771(CHEMBL3898371)
Affinity DataKi:  70nMAssay Description:Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50448581(CHEMBL3127463)
Affinity DataKi:  73nMAssay Description:Binding affinity to human activated protein C assessed as release of p-nitroaniline after 10 to 120 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM14714((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)
Affinity DataKi:  87nM ΔG°:  -39.9kJ/molepH: 7.8 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2007
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380624(CHEMBL2016871)
Affinity DataKi:  90nMAssay Description:Inhibition of activated protein C by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447528(CHEMBL3115904)
Affinity DataKi:  100nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50193234({(R)-1-[2-(4-carbamimidoyl-benzylcarbamoyl)-indan-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447516(CHEMBL3115900)
Affinity DataKi:  100nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50138156(Biphenyl-4-carboxylic acid {1-[(3-aminomethyl-phen...)
Affinity DataIC50: 130nMAssay Description:Compound was tested for inhibition of human activated protein C (APC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human activated protein kinase C using H-D-Lys(Cbo)-Pro-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447515(CHEMBL3115901)
Affinity DataIC50: 130nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50192770(CHEMBL3956096)
Affinity DataKi:  155nMAssay Description:Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50138161(N-{1-[(3-Aminomethyl-phenylcarbamoyl)-methyl]-2-ox...)
Affinity DataIC50: 170nMAssay Description:Compound was tested for inhibition of human activated protein C (APC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50192766(CHEMBL3967204)
Affinity DataKi:  175nMAssay Description:Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  190nMAssay Description:Inhibition of human activated protein C using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447523(CHEMBL3115897)
Affinity DataKi:  200nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108111(US8598206, Table 6, 20)
Affinity DataKi:  210nMAssay Description:Inhibition of human aPC was determined by the method described in [0092]-[0098] using human activated protein C from Enzyme Research Laboratories at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2014
Entry Details
US Patent

TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50192764(CHEMBL3934882)
Affinity DataKi:  220nMAssay Description:Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50380623(CHEMBL2016870)
Affinity DataKi:  223nMAssay Description:Inhibition of activated protein C by dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108112(US8598206, Table 6, 21)
Affinity DataKi:  250nMAssay Description:Inhibition of human aPC was determined by the method described in [0092]-[0098] using human activated protein C from Enzyme Research Laboratories at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2014
Entry Details
US Patent

TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50193230({(R)-1-[2-(4-carbamimidoyl-benzylcarbamoyl)-2,3-di...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447516(CHEMBL3115900)
Affinity DataIC50: 260nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447514(CHEMBL3115903)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447521(CHEMBL3115899)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447517(CHEMBL3115894)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447522(CHEMBL3115898)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108095(US8598206, Table 6, 4)
Affinity DataKi:  310nMAssay Description:Inhibition of human aPC was determined by the method described in [0092]-[0098] using human activated protein C from Enzyme Research Laboratories at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2014
Entry Details
US Patent

TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50192767(CHEMBL3984725)
Affinity DataKi:  340nMAssay Description:Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50193224(((R)-1-{[(S)-(4-carbamimidoyl-benzylcarbamoyl)-ind...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447525(CHEMBL3115893)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108097(US8598206, Table 6, 6)
Affinity DataKi:  400nMAssay Description:Inhibition of human aPC was determined by the method described in [0092]-[0098] using human activated protein C from Enzyme Research Laboratories at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2014
Entry Details
US Patent

TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50425659(CHEMBL2315242)
Affinity DataKi:  420nMAssay Description:Inhibition of human activated protein C using H-D-Lys(Cbz)-Pro-Arg-pNA as substrate after 5 to 10 mins by micro plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50193229({(R)-1-[2-(4-carbamimidoyl-benzylcarbamoyl)-2,3-di...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human aPCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50138154(Biphenyl-4-carboxylic acid {1-[(5-aminomethyl-2-me...)
Affinity DataIC50: 450nMAssay Description:Compound was tested for inhibition of human activated protein C (APC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447528(CHEMBL3115904)
Affinity DataIC50: 470nMAssay Description:Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50193243(({(R)-[2-(4-carbamimidoyl-benzylcarbamoyl)-indan-2...)
Affinity DataKi:  500nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50447527(CHEMBL3115905)
Affinity DataKi:  500nMAssay Description:Competitive inhibition of human APC using S-2366 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi:  555nMAssay Description:Inhibition of human aPC was determined by the method described in [0092]-[0098] using human activated protein C from Enzyme Research Laboratories at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2014
Entry Details
US Patent

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