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TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220380BDBM220380(US9290488, ZA01)
Affinity DataKi:  0.220nM ΔG°:  -55.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177911BDBM177911(US9120797, 9 | US9120797, 10)
Affinity DataKi:  0.260nM ΔG°:  -54.7kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177903BDBM177903(US9120797, 1 | US9120797, 3 | US9120797, 2)
Affinity DataKi:  0.300nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220382BDBM220382(US9290488, ZA03)
Affinity DataKi:  0.340nM ΔG°:  -54.0kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177935BDBM177935(US9120797, 33)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 182732BDBM182732(US9145408, 405)
Affinity DataEC50:  0.550nMpH: 7.4 T: 2°CAssay Description:Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (Receptor Biology) were prepared by lysing cells in ice-co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177903BDBM177903(US9120797, 1 | US9120797, 3 | US9120797, 2)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 172430BDBM172430(US9090618, ZA53 | US9598411, Ref. No. ZA53)
Affinity DataKi:  0.800nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220363BDBM220363(US9290488, B20a(i))
Affinity DataKi:  0.890nM ΔG°:  -51.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177948BDBM177948(US9120797, 46)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 172419BDBM172419(US9090618, ZA42 | US9598411, Ref. No. ZA42)
Affinity DataKi:  0.920nM ΔG°:  -51.6kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220366BDBM220366(US9290488, B34a)
Affinity DataKi:  1.03nM ΔG°:  -51.3kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 182732BDBM182732(US9145408, 405)
Affinity DataKi:  1.10nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Receptor Biology) were prepared by lysing cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177934BDBM177934(US9120797, 32)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177955BDBM177955(US9120797, 53)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 172418BDBM172418(US9090618, ZA41 | US9598411, Ref. No. ZA41)
Affinity DataKi:  1.15nM ΔG°:  -51.0kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177925BDBM177925(US9120797, 23)
Affinity DataKi:  1.20nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177916BDBM177916(US9120797, 14 | US9120797, 15)
Affinity DataKi:  1.20nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 150220BDBM150220(US8980906, 22)
Affinity DataKi:  1.20nM ΔG°:  -55.2kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220366BDBM220366(US9290488, B34a)
Affinity DataEC50:  1.24nMpH: 7.4 T: 2°CAssay Description:ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220379BDBM220379(US9290488, L29b)
Affinity DataKi:  1.32nM ΔG°:  -50.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 16434BDBM16434(US8846929, 290)
Affinity DataKi:  1.40nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177936BDBM177936(US9120797, 34)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 133966BDBM133966(US8846929, 364)
Affinity DataKi:  1.40nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177930BDBM177930(US9120797, 28)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220375BDBM220375(US9290488, K2b(ii))
Affinity DataKi:  1.46nM ΔG°:  -50.4kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177947BDBM177947(US9120797, 45)
Affinity DataKi:  1.60nM ΔG°:  -50.2kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 11828BDBM11828(US8846929, 101)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 16019BDBM16019(US8846929, 288)
Affinity DataKi:  1.80nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 172382BDBM172382(US9090618, H27b(i) | US9598411, Ref. No. H27b(i))
Affinity DataKi:  1.90nM ΔG°:  -49.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220384BDBM220384(US9290488, ZA05)
Affinity DataKi:  1.97nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220383BDBM220383(US9290488, ZA04)
Affinity DataKi:  1.98nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220385BDBM220385(US9290488, ZA06)
Affinity DataKi:  1.98nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 172417BDBM172417(US9090618, ZA40 | US9598411, Ref. No. ZA40)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 17605BDBM17605(US8846929, 298)
Affinity DataKi:  2nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 150219BDBM150219(US8980906, 21)
Affinity DataKi:  2.04nM ΔG°:  -53.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 172433BDBM172433(US9090618, ZA56 | US9598411, Ref. No. ZA56)
Affinity DataKi:  2.05nM ΔG°:  -49.6kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220362BDBM220362(US9290488, B12a)
Affinity DataKi:  2.21nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 18569BDBM18569(US8846929, 362)
Affinity DataKi:  2.40nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 97710BDBM97710(US8476271, 16 | US9145408, 362)
Affinity DataKi:  2.40nM ΔG°:  -45.7kJ/molepH: 7.4 T: 2°CAssay Description:Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Receptor Biology) were prepared by lysing cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177913BDBM177913(US9120797, 11 | US9120797, 12)
Affinity DataKi:  2.40nM ΔG°:  -49.2kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 17276BDBM17276(US8846929, 294)
Affinity DataKi:  2.5nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220363BDBM220363(US9290488, B20a(i))
Affinity DataEC50:  2.62nMpH: 7.4 T: 2°CAssay Description:ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220376BDBM220376(US9290488, K29b)
Affinity DataKi:  2.64nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 172413BDBM172413(US9090618, ZA35 | US9598411, Ref. No. ZA35)
Affinity DataKi:  2.68nM ΔG°:  -48.9kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 12729BDBM12729(US8846929, 127)
Affinity DataKi:  2.70nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 15777BDBM15777(US8846929, 286)
Affinity DataKi:  2.80nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177913BDBM177913(US9120797, 11 | US9120797, 12)
Affinity DataKi:  2.90nM ΔG°:  -48.7kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 177926BDBM177926(US9120797, 24 | US9120797, 25)
Affinity DataKi:  2.90nM ΔG°:  -48.7kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
US Patent

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 220377BDBM220377(US9290488, L2b(i))
Affinity DataKi:  3.07nM ΔG°:  -48.6kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

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