98 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vitae Pharmaceuticals
Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency andß-selectivity of liver X receptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kowa
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)ß Agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vitae Pharmaceuticals
Identification and in Vivo Evaluation of Liver X Receptorß-Selective Agonists for the Potential Treatment of Alzheimer's Disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wuxi Apptec
Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Daiichi Sankyo Rd Novare
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Genentech
Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptorß-selective agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kowa
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Genentech
Design and discovery of 2-oxochromene derivatives as liver X receptorß-selective agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kowa
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Genentech
Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-¿ (ROR¿ or RORc).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Genentech
Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (ROR¿)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Genentech
Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea University
Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea University
Identification of Potent and Selective Diphenylpropanamide ROR? Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
New York University School of Medicine
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea University
Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research and Development
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Pharmaceuticals
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Phenex Pharmaceuticals
Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Pharmaceuticals
Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Pharmaceuticals
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Pharmaceuticals
Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Pharmaceuticals
4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Pharmaceuticals
The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astrazeneca R&D SöDertäLje
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Pharmaceuticals
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Tokyo
Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Design, synthesis and structure-activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Tokyo Medical and Dental University
Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Research Laboratories
LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Southern Medical University
Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Tricyclic-Carbocyclic ROR?t Inverse Agonists-Discovery of BMS-986313.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb
Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sun Yat-Sen University
Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel ROR?t inverse agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb
Azatricyclic Inverse Agonists of ROR?t That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb
Tricyclic sulfones as potent, selective and efficacious ROR?t inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb
Discovery of a Series of Pyrazinone ROR? Antagonists and Identification of the Clinical Candidate BI 730357.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Boehringer Ingelheim Pharmaceuticals
Novel Tricyclic Pyroglutamide Derivatives as Potent ROR?t Inverse Agonists Identified using a Virtual Screening Approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol Myers Squibb
Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus ![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chinese Academy of Sciences
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Goethe University Frankfurt
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Genomics Institute of The Novartis Research Foundation (Gnf)
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR? Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chinese Academy of Sciences
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor ?.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chinese Academy of Sciences
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR?t inverse agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Development of novel liver?X?receptor modulators based on a 1,2,4-triazole scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Benha University
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active ROR?t Inverse Agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Rationally Designed, Conformationally Constrained Inverse Agonists of ROR?t-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (ROR?t) inhibitor, S18-000003.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Shionogi
Recent Advances in the Medicinal Chemistry of Liver X Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Saint Louis University School of Medicine
Structural development of tetrachlorophthalimides as liver X receptor ? (LXR?)-selective agonists with improved aqueous solubility.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (ROR?/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Tokyo
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Research and Development
DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Goethe-University Frankfurt
Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Laboratorium FÜR Organische Chemie
Species orthologs of the alpha-2A adrenergic receptor: the pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of Nebraska
Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Yamanouchi Pharmaceutical