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Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives.

Zeria Pharmaceutical

Synthesis of benzanilide derivatives as dual acting agents with alpha 1-adrenoceptor antagonistic action and steroid 5-alpha reductase inhibitory activity.

Zeria Pharmaceutical

A practical synthesis of 3-substituted delta 3,5(6)-steroids as new potential 5 alpha-reductase inhibitor.

Chinese Academy of Science

Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5a-reductase and on cancer cell line SK-LU-1.

Universidad Nacional Aut£Noma De M£Xico

Effect of dehydroepiandrosterone derivatives on the activity of 5a-reductase isoenzymes and on cancer cell line PC-3.

National University of Mexico

Conformational analysis of an anti-androgenic, (E,E)-8-hydroxygermacrene B, using NOESY and dynamic NMR spectroscopy.

Naresuan University

Steroidal A ring aryl carboxylic acids: a new class of steroid 5 alpha-reductase inhibitors.

Smith Kline & French Laboratories

Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.

Saarland University

Pharmacological options in the treatment of benign prostatic hyperplasia.

Pfizer

Indole derivatives as a new class of steroid 5 alpha-reductase inhibitors.

Kyowa Hakko Kogyo

Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.

Glaxo Inc. Research Institute

Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding.

TBA

Structure activity relationship study of known inhibitors of the enzyme 5 alpha-reductase (5AR).

Kingston University

 

The preparation and evaluation of (+/-)-trans-1-Diazo-8-methoxy-4a-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-2-one as an inhibitor of human type-1 steroid 5α-reductase

TBA

 

Synthesis of a chemiluminescent probe useful for the purification of steroid 5α-reductase

TBA

Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.

Saarland University

Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids.

Changzhi University

N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity.

UniversitäT Des Saarlandes

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

Bristol-Myers Squibb

Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group.

Sankyo

Novel lead generation through hypothetical pharmacophore three-dimensional database searching: discovery of isoflavonoids as nonsteroidal inhibitors of rat 5 alpha-reductase.

TBA

(E)-4-(2-[[3-(indol-5-yl)-1-oxo-2-butenyl]amino]phenoxy)butyric acid derivatives: a new class of steroid 5 alpha-reductase inhibitors in the rat prostate. 1.

Kyowa Hakko Kogyo

Activity of steroid 4 and derivatives 4a-4f as inhibitors of the enzyme 5?-reductase 1.

Universidad Nacional Aut£Noma De M£Xico

Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis.

Institute of Cancer Research

Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids.

Smith Kline & French Laboratories