32 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
The chemistry and pharmacology of privileged pyrroloquinazolines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Oregon Health & Science University
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eisai
Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Harvard Medical School
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Harvard Medical School
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Harvard Medical School
Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute
Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Minnesota
Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
State University of New York
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Southern Research Institute
Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Harvard Medical School
Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cornell University
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Southern Research Institute
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sri International
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Southern Research Institute
Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sri International
Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Southern Research Institute