BDBM50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn

SMILES C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O

InChI Key InChIKey=LPQZKKCYTLCDGQ-WEDXCCLWSA-N

Data  4 KI  82 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 85 hits for monomerid = 50053173   

TargetBeta-lactamase TEM(Escherichia coli)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataKi:  190nMAssay Description:Inhibition of bacterial N-terminal His-tagged TEV protease site linked TEM-1 (24 to 286 amino acids) expressed in Escherichia coli Transetta (DE3) pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Case Western Reserve University

LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataKi:  220nM IC50:  30nMpH: 7.4Assay Description:Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4). IC50, defined as t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetBeta-lactamase(Escherichia coli)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataKi:  7.40E+4nMAssay Description:Inhibition of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase P99 after 5 seconds incubation with nitrocefin substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Escherichia coli)
Institut Pasteur Hellenique

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Escherichia coli beta-lactamase SCO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase TEM(Escherichia coli)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of Escherichia coli K12 TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetallo-beta-lactamase type 2(Bacteroides fragilis)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  2.66E+3nMAssay Description:Inhibitory activity against Bacteroides fragilis 88854 Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase(Citrobacter freundii)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  166nMAssay Description:Inhibitory activity against Citrobacter freundii 87470 Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase TEM(Escherichia coli)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Escherichia coli HA58R Class-III TEM-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  333nMAssay Description:Inhibitory activity against Enterobacter cloacae HC8 Class-I beta-lactamase enzyme type P99More data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Case Western Reserve University

LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  133nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)

TargetBeta-lactamase OXA-1(Escherichia coli)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  432nMAssay Description:Inhibitory activity against Escherichia coli HA209 Class-V OXA-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase(Klebsiella oxytoca)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  106nMAssay Description:Inhibitory activity against Klebsiella oxytoca HC7 Class-IV K1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase(Proteus mirabilis)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Proteus vulgaris HJ33C Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase(Staphylococcus aureus)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  166nMAssay Description:Inhibitory activity against Staphylococcus aureus CJ8 beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase BRO-1(Moraxella catarrhalis)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  33.3nMAssay Description:Inhibitory activity against Branhamella catarrhalis 89001 Class-III BRO-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails

TargetBeta-lactamase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Meiji Seika Pharma

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  950nMpH: 7.0Assay Description:For the measurement of β-lactamase inhibitory activity, 100 μM (final concentration) nitrocefin (Oxoid) was used as a substrate, and 2.5% D...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  943nMAssay Description:Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae P99More data for this Ligand-Target Pair
In DepthDetails Article

TargetBeta-lactamase(Pseudomonas luteola)
Institut Pasteur

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Pseudomonas luteola LAM Beta-lactamase LUT-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Pseudomonas aeruginosa)
H�Pital De Bic�Tre

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Pseudomonas aeruginosa)
H�Pital De Bic�Tre

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Escherichia coli (strain K12))
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.81E+3nMpH: 7.0 T: 37°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  222nMpH: 7.0 T: 37°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetBeta-lactamase TEM(Escherichia coli)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  17.2nMpH: 7.0 T: 37°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae SC 12368 E-2More data for this Ligand-Target Pair
In DepthDetails Article

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Enterobacter cloacae 908RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  830nMAssay Description:Compound was tested for inhibition of Beta-lactamase fromOXA-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  560nMAssay Description:Compound was tested for inhibition of Beta-lactamase from RTEM-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  420nMAssay Description:Compound was tested for inhibition of Beta-lactamase from RTEM-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  560nMAssay Description:Compound was tested for inhibition of Beta-lactamase from PSE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  240nMAssay Description:Compound was tested for inhibition of Beta-lactamase from OXA-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Meiji Seika Pharma

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  820nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa 18SHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  150nMAssay Description:Compound was tested for inhibition of Beta-lactamase from RTEM-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Meiji Seika Pharma

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  3.60E+4nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa MK-1184More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Escherichia coli (strain K12))
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  9.80E+4nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Bacteroides fragilis 98More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  8.50E+4nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Ent. cloacae 6300More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase TEM(Escherichia coli)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory concentration against TEM-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Escherichia coli (strain K12))
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.80E+4nMAssay Description:In vitro inhibitory concentration against AmpC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetallo-beta-lactamase type 2(Bacteroides fragilis)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration against CCRA enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.02E+5nMAssay Description:Inhibitory activity against Class C beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Escherichia coli (strain K12))
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.80E+4nMAssay Description:In vitro inhibitory activity against Beta-lactamase AmpC of class C enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against Beta-lactamase TEM-1 of class A enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory activity against Class A (Imi-1) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetallo-beta-lactamase type 2(Bacteroides fragilis)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.00E+5nMAssay Description:In vitro inhibitory activity against Class B (CCRA) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Escherichia coli (strain K12))
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  8.40E+4nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase TEM(Escherichia coli)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against Class A (TEM-1) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetallo-beta-lactamase type 2(Bacteroides fragilis)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibition of Bacteroides fragilis CcrAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase TEM(Escherichia coli)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  8.40E+4nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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