BDBM50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn

SMILES C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O

InChI Key InChIKey=LPQZKKCYTLCDGQ-WEDXCCLWSA-N

Data  4 KI  82 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 57 hits for monomerid = 50053173   

TargetBeta-lactamase(Escherichia coli)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataKi:  7.40E+4nMAssay Description:Inhibition of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase P99 after 5 seconds incubation with nitrocefin substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Institut Pasteur Hellenique

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Escherichia coli beta-lactamase SCO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Citrobacter freundii)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  166nMAssay Description:Inhibitory activity against Citrobacter freundii 87470 Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  333nMAssay Description:Inhibitory activity against Enterobacter cloacae HC8 Class-I beta-lactamase enzyme type P99More data for this Ligand-Target Pair
In DepthDetails
TargetBeta-lactamase(Klebsiella oxytoca)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  106nMAssay Description:Inhibitory activity against Klebsiella oxytoca HC7 Class-IV K1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-lactamase(Proteus mirabilis)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Proteus vulgaris HJ33C Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-lactamase(Staphylococcus aureus)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  166nMAssay Description:Inhibitory activity against Staphylococcus aureus CJ8 beta-lactamase enzymeMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
Meiji Seika Pharma

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  950nMpH: 7.0Assay Description:For the measurement of β-lactamase inhibitory activity, 100 μM (final concentration) nitrocefin (Oxoid) was used as a substrate, and 2.5% D...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  943nMAssay Description:Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae P99More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase(Pseudomonas luteola)
Institut Pasteur

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Pseudomonas luteola LAM Beta-lactamase LUT-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
H�Pital De Bic�Tre

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
H�Pital De Bic�Tre

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.81E+3nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae SC 12368 E-2More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Enterobacter cloacae 908RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  830nMAssay Description:Compound was tested for inhibition of Beta-lactamase fromOXA-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  560nMAssay Description:Compound was tested for inhibition of Beta-lactamase from RTEM-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  420nMAssay Description:Compound was tested for inhibition of Beta-lactamase from RTEM-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  560nMAssay Description:Compound was tested for inhibition of Beta-lactamase from PSE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  240nMAssay Description:Compound was tested for inhibition of Beta-lactamase from OXA-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
Meiji Seika Pharma

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  820nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa 18SHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  150nMAssay Description:Compound was tested for inhibition of Beta-lactamase from RTEM-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
Meiji Seika Pharma

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  3.60E+4nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa MK-1184More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  9.80E+4nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Bacteroides fragilis 98More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  8.50E+4nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Ent. cloacae 6300More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.80E+4nMAssay Description:In vitro inhibitory concentration against AmpC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.02E+5nMAssay Description:Inhibitory activity against Class C beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.80E+4nMAssay Description:In vitro inhibitory activity against Beta-lactamase AmpC of class C enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against Beta-lactamase TEM-1 of class A enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory activity against Class A (Imi-1) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  8.40E+4nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  8.40E+4nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Citrobacter freundii)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  96nMAssay Description:Inhibition of Citrobacter freundii PER2 beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Serratia fonticola)
University Of Aveiro

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Enterobacter cloacae IMI1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Chu Clermont-Ferrand

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-158More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Escherichia coli CTX-M-15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Institute

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.71E+5nMAssay Description:Inhibition of Escherichia coli beta-lactamase ACC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Klebsiella pneumoniae)
National Institute Of Health Dr. Ricardo Jorge Av. Padre Cruz

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-72More data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa)
Hellenic Pasteur Institute

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of Pseudomonas aeruginosa GES-13 beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Salmonella enterica subsp. enterica serovar Westha...)
Centre National De R£F£Rence Des Salmonella

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Burkholderia cenocepacia)
H�Pital De Bic�Tre

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Burkholderia cenocepacia 07-34 beta-lactamase PenB1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
Meiji Seika Pharma

US Patent
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-lactamase(Enterobacter cloacae)
Novexel

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Staphylococcus aureus)TBA
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  500nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Staphylococcus aureus PCIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Bacillus licheniformis)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50:  510nMAssay Description:Compound was tested for inhibition of Beta-lactamase from Bacillus licheniformis 749/CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed