BDBM127750 US10251889, Example 123::US10758542, Example 123::US8791123, 123::US9782415, Example 123::US9796724, Example 123
SMILES C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1
InChI Key InChIKey=HRNZKBRSPYYSBU-FZKQIMNGSA-N
Data 32 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 127750
Affinity DataIC50: >1.00E+3nMAssay Description:Tyk2: Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
Affinity DataIC50: 6.40nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Jak1: Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Jak3: Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair