BDBM13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::US20230348453, Compound A8::cid_3062316::med.21724, Compound Dasatinib

SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1

InChI Key InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Data  11 KI  187 IC50  891 Kd  5 EC50

PDB links: 21 PDB IDs match this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13216   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  138nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataKd: >3.00E+3nMAssay Description:Binding affinity to AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataKd:  0.800nMAssay Description:Binding affinity to Fyn (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed