BDBM13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155
SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
InChI Key InChIKey=CDMGBJANTYXAIV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 82 hits for monomerid = 13336
Affinity DataIC50: 290nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMpH: 7.5 T: 2°CAssay Description:Kinase assay using p38alpha MAP.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
The R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 at 5 uMMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 78nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 betaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-beta 2More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 370nMAssay Description:Inhibitino of RAF kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 290nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
Affinity DataIC50: 3.45E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of EGF receptor kinaseMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 330nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 2More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coliMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of mitogen-activated protein kinase p38 alpha 2More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Activin like receptor kinase 5, TGF beta type I receptorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 (P38 MAPK)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Transforming growth factor beta-1 receptor (TbetaRI)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against alpha mitogen activated protein kinase p38 activityMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+5nMAssay Description:Inhibition of human Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 462nMAssay Description:Inhibition of mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Inhibition of human cyclin G associated kinase at 100 uM ATPMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human RAF kinase at 100 uM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 500nMAssay Description:Inhibition of Mitogen-activated protein kinase 11 (P38 beta) at 100 uM ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition v-src sarcoma viral oncogene homolog (Src) at 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of Mitogen-activated protein kinase 14 (P38 alpha) at 100 uM ATPMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 124nMAssay Description:Inhibition of human casein kinase 1 delta at 100 uM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human mitogen-activated protein kinase 9 (JNK 2) at 100 uM ATPMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 16nMAssay Description:Inhibition of human receptor-interacting serine-threonine kinase 2 (RIPK2) at 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibitory concentration against p38 alpha MAP kinase (Experimental value)More data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibitory concentration against p38 alpha MAP kinase calculated by CoMFA model; FlexX score=-22.2kcal/mol More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibitory activity against p38alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of p38alpha MAPK by non-radioactive immunosorbent assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 790nMAssay Description:Inhibition of JNK3 by non-radioactive immunosorbent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Tie2 kinase by autophosphorylation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) by cell-free enzyme immunosorbent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cellsMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 120nMAssay Description:Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair