BDBM384192 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 112::US10851110, Example 112::US11466017, Example 112
SMILES CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(N)CC2)c1Cl
InChI Key InChIKey=XLKDUTBYZJONNW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 384192
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair