Compile Data Set for Download or QSAR
Report error Found 641 Enz. Inhib. hit(s) with Target = '5'-AMP-activated protein kinase catalytic subunit alpha-1'
LigandChemical structure of BindingDB Monomer ID 563544BDBM563544(US11407768, Compound 1)
Affinity DataEC50:  0.0500nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563546BDBM563546(US11407768, Compound 3)
Affinity DataEC50:  0.0900nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563547BDBM563547(US11407768, Compound 4)
Affinity DataEC50:  0.100nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565695BDBM565695(US11407768, Compound 74)
Affinity DataEC50:  0.150nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565454BDBM565454(US11407768, Compound 53)
Affinity DataEC50:  0.230nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565696BDBM565696(US11407768, Compound 75)
Affinity DataEC50:  0.370nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563553BDBM563553(US11407768, Compound 10)
Affinity DataEC50:  0.400nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563495BDBM563495(US11407763, Example 45 | (2S)-2-amino-3-(4-(2- am...)
Affinity DataEC50:  0.460nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563556BDBM563556(US11407768, Compound 14)
Affinity DataEC50:  0.5nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 237992BDBM237992(US9394285, 75)
Affinity DataEC50:  0.5nMpH: 7.5 T: 2°CAssay Description:The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 543473BDBM543473(US11279702, Compound 4 | (((6-chloro-5-(2'-hydroxy...)
Affinity DataEC50:  0.550nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563558BDBM563558(US11407768, Compound 29)
Affinity DataEC50:  0.560nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565456BDBM565456(US11407768, Compound 54)
Affinity DataEC50:  0.570nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563549BDBM563549(US11407768, Compound 6)
Affinity DataEC50:  0.620nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565561BDBM565561(US11407768, Compound 71)
Affinity DataEC50:  0.630nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563501BDBM563501(US11407768, Compound 22)
Affinity DataEC50:  0.630nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563503BDBM563503(US11407768, Compound 30 | (2S)-2-amino-3-(4-(2- am...)
Affinity DataEC50:  0.650nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565449BDBM565449(US11407768, Compound 51)
Affinity DataEC50:  0.720nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563504BDBM563504(US11407768, Compound 32)
Affinity DataEC50:  0.760nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565498BDBM565498(US11407768, Compound 65)
Affinity DataEC50:  0.770nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565503BDBM565503(US11407768, Compound 66)
Affinity DataEC50:  0.800nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565452BDBM565452(US11407768, Compound 52)
Affinity DataEC50:  0.810nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563563BDBM563563(US11407768, Compound 36)
Affinity DataEC50:  0.840nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563560BDBM563560(US11407768, Compound 31)
Affinity DataEC50:  0.850nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565483BDBM565483(US11407768, Compound 60)
Affinity DataEC50:  0.850nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565483BDBM565483(US11407768, Compound 60)
Affinity DataEC50:  0.850nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563548BDBM563548(US11407768, Compound 5)
Affinity DataEC50:  0.860nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565476BDBM565476(US11407768, Compound 57)
Affinity DataEC50:  0.890nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565506BDBM565506(US11407768, Compound 67)
Affinity DataEC50:  0.930nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565474BDBM565474(US11407768, Compound 56)
Affinity DataEC50:  0.930nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565478BDBM565478(US11407768, Compound 58)
Affinity DataEC50:  0.930nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563562BDBM563562(US11407768, Compound 33)
Affinity DataEC50:  0.960nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 543471BDBM543471(US11279702, Compound 2 | (((6-chloro-5-(2'-hydroxy...)
Affinity DataEC50:  0.970nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50511116BDBM50511116(CHEMBL4167177)
Affinity DataEC50:  1nMAssay Description:Activation of recombinant mouse AMPK expressed in Sf9 cells using SAMS peptide as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50195478BDBM50195478(CHEMBL3959081)
Affinity DataEC50:  1nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using 5'-FAM-SAMS peptide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 565481BDBM565481(US11407768, Compound 59)
Affinity DataEC50:  1.04nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563566BDBM563566(US11407768, Compound 40)
Affinity DataEC50:  1.08nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565494BDBM565494(US11407768, Compound 63)
Affinity DataEC50:  1.09nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 543477BDBM543477(US11279702, Compound 9 | 2-((6-chloro-5-(2'-hydrox...)
Affinity DataEC50:  1.10nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563568BDBM563568(US11407768, Compound 48)
Affinity DataEC50:  1.16nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 192505BDBM192505(US9187477, 1)
Affinity DataEC50:  1.20nMpH: 7.0Assay Description:In the 384-well plates 1.25 ul of test compound in assay buffer (20 mM HEPES pH 7.0, 0.025% BSA, 15 mM MgCl2, 0.01% Brij) was mixed with 1.25 ul of A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50195538BDBM50195538(CHEMBL3898977)
Affinity DataEC50:  1.20nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using SAMS peptide substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 563550BDBM563550(US11407768, Compound 7)
Affinity DataEC50:  1.22nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 237984BDBM237984(US9394285, 67)
Affinity DataEC50:  1.30nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 565492BDBM565492(US11407768, Compound 62)
Affinity DataEC50:  1.30nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565694BDBM565694(US11407768, Compound 73)
Affinity DataEC50:  1.33nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565486BDBM565486(US11407768, Compound 61)
Affinity DataEC50:  1.36nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 565693BDBM565693(US11407768, Compound 72)
Affinity DataEC50:  1.38nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 543470BDBM543470(US11279702, Compound 1 | 2-((6-chloro-5-(2'-hydrox...)
Affinity DataEC50:  1.40nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 563545BDBM563545(US11407768, Compound 2)
Affinity DataEC50:  1.40nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
US Patent

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