Compile Data Set for Download or QSAR
Report error Found 817 Enz. Inhib. hit(s) with Target = 'Complement C1s subcomponent'
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201566BDBM50201566(CHEMBL2220483)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human C1s esterolytic activity using benzyloxycarbonyl-Lys-thiobenzyl as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50462110BDBM50462110(CHEMBL4244141)
Affinity DataKi:  6nMAssay Description:Inhibition of C1s (unknown origin) using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632958BDBM50632958(CHEMBL5435382)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant N-terminal IgG tagged and C-terminal His tagged C1S (358 to 688 aa residues) expressed in HEK293 cells using Z-Lys-SB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182163BDBM50182163(4-[7-bromo-1-(2,5-difluoro-benzyl)-1H-benzoimidazo...)
Affinity DataKi:  10nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50462090BDBM50462090(CHEMBL4242095)
Affinity DataKi:  11nMAssay Description:Inhibition of human plasma C1s using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233679BDBM50233679(N-[3'-(5-carbamimidoyl-2-methylsulfanyl-thiophene-...)
Affinity DataKi:  14nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182160BDBM50182160(4-[7-bromo-1-(2,6-dichloro-benzyl)-1H-benzoimidazo...)
Affinity DataKi:  20nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233691BDBM50233691(4-(2'-amino-6'-methyl-biphenyl-3-sulfonyl)-5-methy...)
Affinity DataKi:  20nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233674BDBM50233674(6-{3-[3'-(5-carbamimidoyl-2-methylsulfanyl-thiophe...)
Affinity DataKi:  22nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063698BDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human serum C1s using AGLME as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50462111BDBM50462111(CHEMBL4239924)
Affinity DataKi:  30nMAssay Description:Inhibition of C1s (unknown origin) using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182170BDBM50182170(4-[7-bromo-1-(2-fluoro-5-nitro-benzyl)-1H-benzoimi...)
Affinity DataKi:  30nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182171BDBM50182171(4-(1-benzyl-7-bromo-1H-benzoimidazole-5-sulfonyl)-...)
Affinity DataKi:  30nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233686BDBM50233686(4-(2'-methyl-biphenyl-3-sulfonyl)-5-methylsulfanyl...)
Affinity DataKi:  30nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50632959BDBM50632959(CHEMBL5417464)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant N-terminal IgG tagged and C-terminal His tagged C1S (358 to 688 aa residues) expressed in HEK293 cells using Z-Lys-SB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233688BDBM50233688(4-(2'-chloro-biphenyl-3-sulfonyl)-5-methylsulfanyl...)
Affinity DataKi:  40nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233692BDBM50233692(4-[3-(6-methyl-pyridin-2-yl)-benzenesulfonyl]-5-me...)
Affinity DataKi:  40nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182159BDBM50182159(4-[7-bromo-1-(2,6-difluoro-benzyl)-1H-benzoimidazo...)
Affinity DataKi:  40nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233694BDBM50233694(5-[3'-(5-carbamimidoyl-2-methylsulfanyl-thiophene-...)
Affinity DataKi:  42nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201566BDBM50201566(CHEMBL2220483)
Affinity DataIC50: 46nMAssay Description:Inhibition of human serum C1s-mediated lysis of rabbit Ab-sensitized sheep erythrocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233677BDBM50233677(4-(2'-hydroxymethyl-6'-methyl-biphenyl-3-sulfonyl)...)
Affinity DataKi:  50nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182176BDBM50182176(4-[7-bromo-1-(3-methyl-but-2-enyl)-1H-benzoimidazo...)
Affinity DataKi:  50nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147047BDBM50147047(5-Methylsulfanyl-4-[4-(1-phenyl-5-propyl-1H-pyrazo...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233689BDBM50233689(5-methylsulfanyl-4-(6'-methyl-2'-{3-[2-(2H-tetrazo...)
Affinity DataKi:  64nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182185BDBM50182185(4-(1-allyl-7-bromo-1H-benzoimidazole-5-sulfonyl)-5...)
Affinity DataKi:  70nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201567BDBM50201567(CHEMBL3901198)
Affinity DataKi:  70nMAssay Description:Binding affinity to human C1S assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147046BDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  70nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147059BDBM50147059(4-[4-(5-Ethoxy-1-phenyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785979BDBM785979((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785980BDBM785980((S)-7-((acridine-2- carbonyl)glycyl)-N-((R)- 1-(4-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785983BDBM785983((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785984BDBM785984((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785985BDBM785985((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785986BDBM785986((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785987BDBM785987((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785988BDBM785988((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785969BDBM785969((1S,3S,5R)-5-((3- aminopropoxy)methyl)- N-((R)-1-(...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785970BDBM785970(N-(2-((2S,4R)-2-(((R)-1- (4- carbamimidoylthiophen...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785972BDBM785972((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785973BDBM785973((S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785975BDBM785975((S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785976BDBM785976(N-(2-((2S,4R)-2-(((R)-1- (4- carbamimidoylthiophen...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785961BDBM785961((S)-7-((9H-carbazole-2- carbonyl)glycyl)-N-((R)- 1...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785962BDBM785962((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785963BDBM785963((S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hy...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785964BDBM785964((2S,4S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785965BDBM785965((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785966BDBM785966((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785967BDBM785967((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 785968BDBM785968((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details US Patent

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