Compile Data Set for Download or QSAR
Report error Found 145 Enz. Inhib. hit(s) with Target = 'Interleukin-17A'
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582230BDBM50582230(CHEMBL5091495)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578383BDBM50578383(CHEMBL4870813)
Affinity DataIC50: 1nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582227BDBM50582227(CHEMBL5081660)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582229BDBM50582229(CHEMBL5080633)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582232BDBM50582232(CHEMBL5091603)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582228BDBM50582228(CHEMBL5077953)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582231BDBM50582231(CHEMBL5092697)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578381BDBM50578381(CHEMBL4860574)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578382BDBM50578382(CHEMBL4865978)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578386BDBM50578386(CHEMBL4872143)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574356BDBM50574356(CHEMBL4845695 | US12252491, Example 27)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578384BDBM50578384(CHEMBL4850368)
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578385BDBM50578385(CHEMBL4851738)
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574357BDBM50574357(CHEMBL4855085 | US12252491, Example 28)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573258BDBM50573258(CHEMBL4869568)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to biotinylated human IL-17A by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574355BDBM50574355(CHEMBL4874078 | US12252491, Example 26)
Affinity DataIC50: 7nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581144BDBM50581144(CHEMBL5087050)
Affinity DataIC50: 9nMAssay Description:Inhibition of IL-17A (unknown origin) measured by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 727042BDBM727042(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50574352BDBM50574352(CHEMBL4876088 | US12252491, Example 19)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 727041BDBM727041(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50574355BDBM50574355(CHEMBL4874078 | US12252491, Example 26)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50574356BDBM50574356(CHEMBL4845695 | US12252491, Example 27)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 727048BDBM727048(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[(1S)-2-methoxy...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 727049BDBM727049(4-Cyclopropyl-N—[(S)-(4,4-difluorocyclohexyl)-[7-[...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 727047BDBM727047(N—[(S)-(4,4-difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50574353BDBM50574353(CHEMBL4860250 | US12252491, Example 20)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50574354BDBM50574354(CHEMBL4866932 | US12252491, Example 21)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50574357BDBM50574357(CHEMBL4855085 | US12252491, Example 28)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 727035BDBM727035(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 726971BDBM726971(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 9.45nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574354BDBM50574354(CHEMBL4866932 | US12252491, Example 21)
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574352BDBM50574352(CHEMBL4876088 | US12252491, Example 19)
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 726976BDBM726976(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 10.6nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 727046BDBM727046(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 11.4nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573255BDBM50573255(CHEMBL4858175)
Affinity DataKd:  12nMAssay Description:Binding affinity to human IL-17A assessed as dissociation constant in PBS-T measured after 60 mins by Biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573257BDBM50573257(CHEMBL4878993)
Affinity DataKd:  13nMAssay Description:Binding affinity to human IL-17A assessed as dissociation constant in PBS-T measured after 60 mins by Biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 726969BDBM726969(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 13nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574353BDBM50574353(CHEMBL4860250 | US12252491, Example 20)
Affinity DataIC50: 14nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 726828BDBM726828(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 15.2nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 726975BDBM726975(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 15.5nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 726720BDBM726720(3-Cyclopropyl-N—[(S)-(4,4-difluorocyclohexyl)-[7-[...)
Affinity DataIC50: 15.7nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575029BDBM50575029(CHEMBL4864604)
Affinity DataIC50: 17nMAssay Description:Inhibition of IL-17A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 727036BDBM727036(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 18.1nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 727040BDBM727040(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 19.3nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 726970BDBM726970(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 20nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 726905BDBM726905(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 27.7nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581145BDBM50581145(CHEMBL5079201)
Affinity DataKd:  30nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597429BDBM50597429(CHEMBL5194116)
Affinity DataKd:  32nMAssay Description:Binding affinity to human IL-17A assessed as thermal stability by measuring increase in unfolding temperature by differential scanning fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 727038BDBM727038(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 36.1nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 726974BDBM726974(N—[(S)-(4,4-Difluorocyclohexyl)-[7-[[(4S)-2-oxo-4-...)
Affinity DataIC50: 37.8nMAssay Description:The ability of compounds to inhibit the binding of IL-17A to IL-17RA may be assessed with an AlphaLISA assay. Expression and purification of protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

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