Compile Data Set for Download or QSAR
Report error Found 133 Enz. Inhib. hit(s) with Target = 'Neurogenic locus notch homolog protein 1'
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074771BDBM50074771(CHEMBL3410153)
Affinity DataIC50: 1nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074796BDBM50074796(CHEMBL3410169)
Affinity DataIC50: 1nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074818BDBM50074818(CHEMBL3410163)
Affinity DataIC50: 1nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209895BDBM209895(US9273014, 24)
Affinity DataIC50: 1.40nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209891BDBM209891(US9273014, 20)
Affinity DataIC50: 1.60nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242882BDBM242882(US9427442, 10)
Affinity DataIC50: 1.70nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209896BDBM209896(US9273014, 25)
Affinity DataIC50: 1.70nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209874BDBM209874(US9273014, 3)
Affinity DataIC50: 1.80nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074784BDBM50074784(CHEMBL3410151)
Affinity DataIC50: 2nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074799BDBM50074799(CHEMBL3410167)
Affinity DataIC50: 2nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074798BDBM50074798(CHEMBL3410168)
Affinity DataIC50: 2nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074795BDBM50074795(CHEMBL3410170)
Affinity DataIC50: 2nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50541992BDBM50541992(CHEMBL4644426)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Notch1 expressed in HEK293 cells coexpressing luciferase reporter measured after 20 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 242883BDBM242883(US9427442, 11)
Affinity DataIC50: 2.10nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209876BDBM209876(US9273014, 5)
Affinity DataIC50: 2.30nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209881BDBM209881(US9273014, 10)
Affinity DataIC50: 2.5nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242890BDBM242890(US9427442, 18)
Affinity DataIC50: 2.70nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209902BDBM209902(US9273014, 31)
Affinity DataIC50: 2.80nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209898BDBM209898(US9273014, 27)
Affinity DataIC50: 2.80nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242885BDBM242885(US9427442, 13)
Affinity DataIC50: 2.80nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242880BDBM242880(US9427442, 8)
Affinity DataIC50: 2.90nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242891BDBM242891(US9427442, 19)
Affinity DataIC50: 2.90nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074777BDBM50074777(CHEMBL3410152)
Affinity DataIC50: 3nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50541988BDBM50541988(CHEMBL4645821)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Notch1 expressed in HEK293 cells coexpressing luciferase reporter measured after 20 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 242873BDBM242873(US9427442, 1)
Affinity DataIC50: 3nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074695BDBM50074695(CHEMBL3410160)
Affinity DataIC50: 3nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209883BDBM209883(US9273014, 12)
Affinity DataIC50: 3nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074693BDBM50074693(CHEMBL3410162)
Affinity DataIC50: 3nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209880BDBM209880(US9273014, 9 | US9273014, 11)
Affinity DataIC50: 3nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074813BDBM50074813(CHEMBL3410164)
Affinity DataIC50: 3nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209893BDBM209893(US9273014, 22)
Affinity DataIC50: 3.10nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242894BDBM242894(US9427442, 22)
Affinity DataIC50: 3.20nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209892BDBM209892(US9273014, 21)
Affinity DataIC50: 3.30nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209884BDBM209884(US9273014, 13)
Affinity DataIC50: 3.40nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242881BDBM242881(US9427442, 9)
Affinity DataIC50: 3.5nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209897BDBM209897(US9273014, 26)
Affinity DataIC50: 3.70nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242897BDBM242897(US9427442, 25)
Affinity DataIC50: 3.80nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242879BDBM242879(US9427442, 7)
Affinity DataIC50: 3.90nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242896BDBM242896(US9427442, 24)
Affinity DataIC50: 3.90nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209900BDBM209900(US9273014, 29)
Affinity DataIC50: 3.90nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50074694BDBM50074694(CHEMBL3410161)
Affinity DataIC50: 4nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 242875BDBM242875(US9427442, 3)
Affinity DataIC50: 4.20nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209901BDBM209901(US9273014, 30 | US9273014, 35)
Affinity DataIC50: 4.30nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209904BDBM209904(US9273014, 33)
Affinity DataIC50: 4.30nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209886BDBM209886(US9273014, 15)
Affinity DataIC50: 4.40nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242877BDBM242877(US9427442, 5)
Affinity DataIC50: 4.40nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242887BDBM242887(US9427442, 15)
Affinity DataIC50: 4.40nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209878BDBM209878(US9273014, 7)
Affinity DataIC50: 4.40nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 242886BDBM242886(US9427442, 14)
Affinity DataIC50: 4.5nMAssay Description:The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetNeurogenic locus notch homolog protein 1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209889BDBM209889(US9273014, 18)
Affinity DataIC50: 4.60nMAssay Description:The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2017
Entry Details
US Patent

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