Compile Data Set for Download or QSAR
Report error Found 385 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily KQT member 2'
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50442471BDBM50442471(CHEMBL2440363)
Affinity DataEC50:  0.900nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50442470BDBM50442470(CHEMBL401942)
Affinity DataEC50:  2.40nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557812BDBM557812(US11365181, Compound 03058)
Affinity DataEC50:  8nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50410081BDBM50410081(CHEMBL361184)
Affinity DataEC50:  10nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50410081BDBM50410081(CHEMBL361184)
Affinity DataEC50:  10nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50410077BDBM50410077(CHEMBL180886)
Affinity DataEC50:  20nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50463349BDBM50463349(CHEMBL4250878)
Affinity DataEC50:  20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697196BDBM697196(US20240316020, Example 11 | 1-[[2- (difluoromethox...)
Affinity DataEC50:  20nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50410077BDBM50410077(CHEMBL180886)
Affinity DataEC50:  20nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697189BDBM697189(US20240316020, Example 4 | 1-[[2- (difluoromethoxy...)
Affinity DataEC50:  20nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50463341BDBM50463341(CHEMBL4238783)
Affinity DataEC50:  20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697190BDBM697190(US20240316020, Example 5 | 1-[[2-(2,2- difluoropro...)
Affinity DataEC50:  20nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557809BDBM557809(US11365181, Compound 03043)
Affinity DataEC50:  23nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50463346BDBM50463346(CHEMBL4250403)
Affinity DataEC50:  30nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50463345BDBM50463345(CHEMBL4247074)
Affinity DataEC50:  34nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601513BDBM50601513(CHEMBL5180351)
Affinity DataEC50:  37nMAssay Description:Agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50463342BDBM50463342(CHEMBL4247002)
Affinity DataEC50:  40nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50529214BDBM50529214(CHEMBL343822)
Affinity DataIC50: 48nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557815BDBM557815(US11365181, Compound 03066)
Affinity DataEC50:  49nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 700206BDBM700206(US20240336571, Example 47 | 1-[[2- (difluoromethox...)
Affinity DataEC50:  50nMAssay Description:At the beginning of each assay, 20 μl of cell suspension was dispensed into each well of a multi-hole 384-well SyncroPatch chip by the onboard p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697192BDBM697192(US20240316020, Example 7 | 1-[[2- (cyclopropylmeth...)
Affinity DataEC50:  50nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50592357BDBM50592357(CHEMBL5185685)
Affinity DataEC50:  50nMAssay Description:Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50529215BDBM50529215(CHEMBL342375 | CHEBI:35046)
Affinity DataIC50: 55nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557810BDBM557810(US11365181, Compound 03044)
Affinity DataEC50:  57nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143560BDBM50143560(N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4...)
Affinity DataEC50:  60nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143560BDBM50143560(N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4...)
Affinity DataEC50:  60nMAssay Description:Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143560BDBM50143560(N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4...)
Affinity DataEC50:  60nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697193BDBM697193(US20240316020, Example 8 | 1-[[2- (difluoromethoxy...)
Affinity DataEC50:  60nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697191BDBM697191(US20240316020, Example 6 | 1-[[2-(2- fluoropropoxy...)
Affinity DataEC50:  60nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557818BDBM557818(US11365181, Compound A (WO2014/048165 A1))
Affinity DataEC50:  65nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84190BDBM84190(SMR000714776 | (2,6-dimethylmorpholin-4-yl)-(6-met...)
Affinity DataIC50: 68.1nMAssay Description:Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC_KCNQ2_Inh_HFCP_IWS_CRC) Center Affiliation: Johns Hopkins University, School of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2012
Entry Details
PCBioAssay
TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84168BDBM84168(SMR000178084 | MLS000562779 | cid_1167408 | 2-[2,4...)
Affinity DataIC50: 69.9nMAssay Description:Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC_KCNQ2_Inh_HFCP_IWS_CRC) Center Affiliation: Johns Hopkins University, School of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2012
Entry Details
PCBioAssay
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 700173BDBM700173(US20240336571, Example 14 | 1-[(1R,2S)-2- phenylcy...)
Affinity DataEC50:  70nMAssay Description:At the beginning of each assay, 20 μl of cell suspension was dispensed into each well of a multi-hole 384-well SyncroPatch chip by the onboard p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697198BDBM697198(US20240316020, Example 13 | 1-[2-hydroxy-1- [2-(2,...)
Affinity DataEC50:  70nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 700198BDBM700198(US20240336571, Example 39 | 1-[(1R,2S)-2- phenylcy...)
Affinity DataEC50:  70nMAssay Description:At the beginning of each assay, 20 μl of cell suspension was dispensed into each well of a multi-hole 384-well SyncroPatch chip by the onboard p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50395464BDBM50395464(CHEMBL2164048)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557807BDBM557807(US11365181, Compound 03034)
Affinity DataEC50:  71nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50526877BDBM50526877(CHEMBL4545892)
Affinity DataEC50:  80nMAssay Description:Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557803BDBM557803(US11365181, Compound 03026)
Affinity DataEC50:  88nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84176BDBM84176(N-(2-methylphenyl)-2-[methyl(phenylsulfonyl)amino]...)
Affinity DataIC50: 92.3nMAssay Description:Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC_KCNQ2_Inh_HFCP_IWS_CRC) Center Affiliation: Johns Hopkins University, School of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2012
Entry Details
PCBioAssay
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 557819BDBM557819(US11365181, Compound B (WO2008/024398 A2))
Affinity DataEC50:  98nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 697214BDBM697214(US20240316020, Example 29 | 1-[[2-(2,3- difluoropr...)
Affinity DataEC50:  100nMAssay Description:Human Kv7.2, Kv7.4 or Kv7.5/7.3 channels were evaluated using a voltage protocol in which cells were voltage-clamped at a holding potential of -60 mV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 700166BDBM700166(US20240336571, Example 7 | 1-[[2- (difluoromethoxy...)
Affinity DataEC50:  100nMAssay Description:At the beginning of each assay, 20 μl of cell suspension was dispensed into each well of a multi-hole 384-well SyncroPatch chip by the onboard p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84171BDBM84171(MLS000516664 | SMR000342833 | cid_2366328 | N-(2-m...)
Affinity DataIC50: 110nMAssay Description:Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC_KCNQ2_Inh_HFCP_IWS_CRC) Center Affiliation: Johns Hopkins University, School of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2012
Entry Details
PCBioAssay
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50410082BDBM50410082(CHEMBL179854)
Affinity DataEC50:  120nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50463347BDBM50463347(CHEMBL4246596)
Affinity DataEC50:  120nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 700195BDBM700195(US20240336571, Example 36 | 1-[[2- (difluoromethox...)
Affinity DataEC50:  120nMAssay Description:At the beginning of each assay, 20 μl of cell suspension was dispensed into each well of a multi-hole 384-well SyncroPatch chip by the onboard p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50395501BDBM50395501(CHEMBL2163658)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50272438BDBM50272438(CHEMBL4128096)
Affinity DataEC50:  130nMAssay Description:Activation of KCNQ2 (unknown origin) expressed in CHO cells at 10 uM after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
Shanghai Zhimeng Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50395505BDBM50395505(CHEMBL2164068)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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