Compile Data Set for Download or QSAR
Report error Found 761 Enz. Inhib. hit(s) with Target = 'Protein kinase C epsilon type'
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataIC50: 0.110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.143nMAssay Description:Inhibition of human PKCepsilon using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM102423(Bryostatin | Bryostatin 7)
Affinity DataKd:  0.160nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.198nMAssay Description:Inhibition of human PKCepsilon using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.220nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of 100 ug/ml 100% phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50092014(Butyric acid (1aS,1bS,4aS,7aS,8R,9S,9aR)-9-butyryl...)
Affinity DataKd:  0.220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
LigandPNGBDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.25nMAssay Description:Binding constant for PRKCE kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.25nMAssay Description:Binding constant for PRKCE kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  0.25nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
LigandPNGBDBM50133236(Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopr...)
Affinity DataKd:  0.370nMAssay Description:Binding affinity for human Protein kinase C epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099066(phorbol 13-acetate 12-myristate | CHEMBL279115)
Affinity DataKi:  0.450nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50229772(1-hexylindolactam-V | CHEMBL399981)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]PDBu from PKCepsilon C1B domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50133236(Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopr...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of human Protein kinase C epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50097750(Butyric acid (1aR,1bS,4aS,7aR,7bR,8R,9R,9aS)-9-but...)
Affinity DataKi:  0.580nMAssay Description:Displacement of 3[H]PDBu from Protein kinase C epsilon C1a domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.590nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of nuclear membrane mimetic lipid mixtureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His-tagged recombinant PKC-epsilon (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50391386(CHEMBL2148106)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]PDBu binding to PKCepsilon C1B domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393214(CHEMBL2151411)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.810nMAssay Description:Binding affinity for protein kinase C epsilon-C1B domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.810nMAssay Description:Binding affinity for Protein kinase C epsilon C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.810nMAssay Description:Inhibition of [3H]PDBu binding to PKCepsilon-C1B domain peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  0.810nMAssay Description:Inhibition of [3H]PDBu binding to PKCepsilon C1B peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PKCepsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50057514(13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC epsilon expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50107120(2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-i...)
Affinity DataKi:  1nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of 100 ug/ml 100% phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50427363(CHEMBL2326002)
Affinity DataKi:  1nMAssay Description:Inhibition of PKC epsilon (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50059676(CHEMBL3393748)
Affinity DataKi:  1.20nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of 100 ug/ml 100% phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50327943(Aplysiatoxin | CHEMBL1256416)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]PDBu binding to PKCepsilon C1B peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50493217(DEMETHOXYDEBROMOAPLYSIATOXIN)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]PDBu from PKCepsilon C1B domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKi:  1.40nMAssay Description:Displacement of 3[H]PDBu from Protein kinase C epsilon C1a domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50107120(2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-i...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of nuclear membrane mimetic lipid mixtureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant PKCE expressed in Bac-to Bac baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.5nMAssay Description:Displacement of [3H]PDBu from protein kinase C epsilon C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50107120(2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-i...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-PDBu from recombinant human PKCepsilon by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50391388(CHEMBL2148108)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]PDBu binding to PKCepsilon C1B domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50313569((E)-4-(4-methyl-1H-indol-5-ylamino)-5-(2-(6-((4-me...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50393228(CHEMBL2153750)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50059781(CHEMBL3393741)
Affinity DataKi:  2.10nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of 100 ug/ml 100% phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50017890(CHEMBL3289012)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]PDBu from recombinant human PKC-epsilon after 5 mins by scintillation counting analysis in presence of phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50216860(Z-[2-(Hydroxymethyl)-4-(3-methylbutylidene)-5-oxo-...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of 100 ug/ml 100% phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50302042(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PKCepsilon by IMAP fluorescence polarization technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50280750(CHEMBL4160361)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]PDBu from full length recombinant human PKCepsilon expressed in baculovirus expression system after 5 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50059676(CHEMBL3393748)
Affinity DataKi:  3nMAssay Description:Displacement of [20-3H] phorbol 12, 13-dibutylate from recombinant PKCepsilon (unknown origin) in presence of nuclear membrane mimetic lipid mixtureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
LigandPNGBDBM33971(Sotrastaurin | AEB071 | med.21724, Compound 190)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PKCepsilon (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50393219(CHEMBL2151415)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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