Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with Target = 'Tyrosine--tRNA ligase, cytoplasmic'
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18128BDBM18128(CHEMBL310012 | (2S)-2-[(2S)-2-amino-3-(4-hydroxyph...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097749BDBM50097749([2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50091497BDBM50091497((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from Staphylococcus aureus was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50091497BDBM50091497((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18128BDBM18128(CHEMBL310012 | (2S)-2-[(2S)-2-amino-3-(4-hydroxyph...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from Staphylococcus aureus was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097746BDBM50097746((S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104311BDBM50104311((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 3.40nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097748BDBM50097748([2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 3.60nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18132BDBM18132((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50091496BDBM50091496((R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from Staphylococcus aureus was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  57nMAssay Description:Binding affinity to human YARS incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097744BDBM50097744((S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097744BDBM50097744((S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104310BDBM50104310((R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 124nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  157nMAssay Description:Binding affinity to human YARS incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097747BDBM50097747([2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104313BDBM50104313((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 245nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097745BDBM50097745([2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 260nMAssay Description:Inhibitory activity against Staphylococcus aureus tyrosyl tRNA synthetase (YRS) using aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081838BDBM50081838([(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 510nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081839BDBM50081839([(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 800nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081834BDBM50081834((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 900nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081837BDBM50081837([(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104314BDBM50104314((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50104312BDBM50104312((R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081841BDBM50081841([(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 3.40E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081840BDBM50081840((S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataIC50: 3.80E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081836BDBM50081836([(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-...)
Affinity DataIC50: 7.80E+3nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081835BDBM50081835((S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylami...)
Affinity DataIC50: 1.10E+4nMAssay Description:Compound was tested for inhibition of Staphylococcus aureus tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18128BDBM18128(CHEMBL310012 | (2S)-2-[(2S)-2-amino-3-(4-hydroxyph...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity of compound against tyrosyl tRNA synthetase from mammalian cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTyrosine--tRNA ligase, cytoplasmic(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20461BDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataKi:  4.20E+4nMAssay Description:Compound was tested for the inhibition of aminoacyl tRNA SynthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article