Compound Name

SMILES String

Cn1cc(\C=C\c2n[nH]c3ccnc(OC4CCCCC4)c23)cn1

CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)N4CCOCC4)n(c3)C(C)C)c12

CN1CCc2c1cccc2-c1n[nH]c2ccnc(OC3CCOCC3)c12

CNC(=O)c1cccc(c1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C[C@H]1CCCN(C1)C(=O)CCc1[nH]nc2ccnc(NC3CCOCC3)c12 |r|

O=C(CCc1[nH]nc2ccnc(OC3CCCCC3)c12)N1CCC[C@@H](C1)c1ccccc1 |r|

O=C(CCc1[nH]nc2ccnc(NC3CCCCC3)c12)N1CCN(CC1)C1CC1

C1CC(CCO1)Nc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12

CN1CCN(CC1)c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1CC1c1[nH]nc2ccnc(OC3CCCCC3)c12

C1CC1c1[nH]nc2ccnc(OC3CCOCC3)c12

CCC(C)Oc1nccc2n[nH]c(C3CC3)c12

Cc1[nH]nc2ccnc(OC3CCOC3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccco3)c12

C1CCC(C1)n1cc(cn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C(C1CCC1)n1cc(cn1)-c1n[nH]c2ccnc(OC3CCCCC3)c12

CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)N(C)C)n(c3)C(C)C)c12

CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)N4CCCCC4)n(c3)C(C)C)c12

CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)NC4COC4)n(c3)C(C)C)c12

COc1nccc2[nH]nc(-c3cc(C(=O)N(C)C)n(c3)C(C)C)c12

COc1nccc2[nH]nc(-c3cc(C(=O)NC4COC4)n(c3)C(C)C)c12

CC(C)n1cc(cc1C(=O)N1CCOCC1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(C)n1cc(cc1C(=O)N(C)C)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(C)n1cc(cc1C(=O)NC1COC1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

O=C(N1CCOCC1)c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

FC(F)(F)COc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12

CC(C)n1cc(cn1)-c1n[nH]c2ccnc(OCC(F)(F)F)c12

CC(C)n1cc(cn1)-c1n[nH]c2ccnc(OC(C)C(F)(F)F)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccnc(n3)N3CCOCC3)c12

COc1nccc2[nH]nc(-c3cnn(c3)C3COC3)c12

COc1nccc2[nH]nc(-c3cnn(CC(F)(F)F)c3)c12

COc1nccc2[nH]nc(-c3cnn(CC4(C)COC4)c3)c12

C(C1CCOCC1)n1cc(cn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

FC(F)(F)Cn1cc(cn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1CC(CO1)n1cc(cn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

Cc1cc(cc(C)n1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

COc1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

Fc1c(ccnc1N1CCOCC1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

COc1cc(ccn1)-c1n[nH]c2ccnc(OC)c12

COc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12

COc1nccc2[nH]nc(-c3ccnc(c3)C(F)(F)F)c12

COc1nccc2n[nH]c(-c3ccc(C(=O)N4CCOCC4)c(Cl)c3)c12

C1CCN(C1)c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC1CCCN(C1)c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1OCC1Nc1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1CN(C1)c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

Cn1cc(cn1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

COc1nccc2[nH]nc(-c3ccnc(c3)N3[C@H]4CC[C@@H]3COC4)c12 |r,THB:14:16:21.22.23:19.18|

COc1nccc2[nH]nc(-c3ccnc(c3)N3C[C@@H]4C[C@H]3CO4)c12 |r|

COc1nccc2[nH]nc(-c3ccnc(c3)N3CCCC3)c12

COc1nccc2[nH]nc(-c3ccnc(c3)-c3cnn(C)c3)c12

CC(C)n1cnc2ccc(cc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1OCC1n1cnc2cc(ccc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1OCC1n1cnc2ccc(cc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

FC1(F)CC1Cn1cnc2ccc(cc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1CC(CO1)n1cnc2ccc(cc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1CC(CO1)n1cnc2cc(ccc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

Clc1ccccc1C#Cc1[nH]nc2ccnc(OC3CCOCC3)c12

O=C(N1CCOCC1)c1ccc(cc1)-c1[nH]nc2ccnc(OC3CCOCC3)c12

CN(C)C(=O)c1ccc(cc1F)-c1[nH]nc2ccnc(OC3CCOCC3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccc4cn[nH]c4c3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccc4nc[nH]c4c3)c12

Cn1ncc2cc(ccc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(C)n1cc2ccc(cc2n1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

Cn1cnc2cc(ccc12)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1C[C@H](CO1)n1cc(cn1)-c1c[nH]c2ccnc(OC3CCOCC3)c12 |r|

C1C[C@@H](CO1)n1cc(cn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12 |r|

Cc1[nH]nc2cc(nc(OC3CCCCC3)c12)C1CC1

C1CC(CCO1)Oc1nccc2[nH]nc(-c3cnc4ccccc4c3)c12

N#CCc1cccc(c1)-c1[nH]nc2ccnc(OC3CCOCC3)c12

CN(C)c1cccc(c1)-c1[nH]nc2ccnc(OC3CCOCC3)c12

CC(C)NC(=O)c1cccc(c1)-c1[nH]nc2ccnc(OC3CCOCC3)c12

O=C(NC1CC1)c1cccc(c1)-c1[nH]nc2ccnc(OC3CCOCC3)c12

N#Cc1cncc(c1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3cccc4[nH]ccc34)c12

C(N1CCOCC1)c1cccc(c1)-c1[nH]nc2ccnc(OC3CCOCC3)c12

COc1cc(Nc2[nH]nc3ccnc(OC4CCOCC4)c23)ccn1

C1CC(CCO1)Oc1nccc2n[nH]c(Nc3ccncc3)c12

CC(C)n1cc(Nc2[nH]nc3ccnc(OC4CCOCC4)c23)cn1

CS(=O)(=O)c1cccc(c1)-c1[nH]nc2ccnc(OC3CCOCC3)c12

COc1nccc2n[nH]c(-c3cccc(c3)S(C)(=O)=O)c12

CC(C)c1nc(n[nH]1)-c1n[nH]c2ccnc(NC3CCOCC3)c12

CNC(=O)c1cccc(c1)-c1[nH]nc2cc(C)nc(OC3CCOCC3)c12

Cc1cc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c2c(OC2CCOCC2)n1

COc1nccc2n[nH]c(-c3ccc(cc3)S(C)(=O)=O)c12

N#Cc1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

Cn1cccc(Nc2n[nH]c3ccnc(OC4CCOCC4)c23)c1=O

CC(Oc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12)C(F)(F)F

COCCOc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12

O=C1OCCN1CCOc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12

CC(C)n1cc(cn1)-c1n[nH]c2ccnc(OCCN3CCOC3=O)c12

COc1nccc2[nH]nc(-c3cnn(c3)C3CCOCC3)c12

COC(=O)c1[nH]nc2ccnc(NC3CCOCC3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3cnn(c3)C3CCOCC3)c12

Cc1[nH]nc2ccnc(NC3CCOCC3)c12

C1CC(CO1)Oc1nccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c12

Cc1[nH]nc2ccnc(OC3CCCC3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccnc(c3)-c3cccnc3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccnc(c3)-c3ccncc3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccnc(c3)-c3cncnc3)c12

N#Cc1cccc(c1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

N#Cc1ccc(cc1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CN(C)C(=O)c1cccc(c1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccnc(c3)-c3cn[nH]c3)c12

CC(=O)Nc1ccccc1-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(=O)Nc1ccc(cn1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(=O)Nc1cccc(c1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(=O)Nc1ccc(cc1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CNC(=O)c1cccc(c1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CN(C)C(=O)c1ccc(cc1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CCn1cc(cn1)-c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)N4CCCC4)n(c3)C(C)C)c12

CC(C)n1cc(cc1C(=O)N1CCC1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(C)Oc1nccc2[nH]nc(-c3ccnc(c3)C(=O)N3C[C@@H]4C[C@H]3CO4)c12 |r,TLB:18:20:26.25:23|

O=C(N1CCCC1)c1cc(ccn1)-c1n[nH]c2ccnc(OC3CCOCC3)c12

CC(C)n1cc(cn1)-c1n[nH]c2ccnc(OC3CCOC3)c12

COc1nccc2[nH]nc(-c3cnn(c3)C3CCOC3)c12

CNC(=O)c1cccc(c1)-c1[nH]nc2cc(C)nc(OC)c12

COc1nccc2[nH]nc(-c3ccnc(c3)N3C[C@H](C)O[C@H](C)C3)c12 |r|

CNc1nc(Nc2ccc(cc2Cl)-c2nnn[nH]2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2Cl)-c2nnnn2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2Cl)-c2nnn(C)n2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-n2cncn2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2cnn(C)c2)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-c2nc(C)no2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2nnc(C)o2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2cncn2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2nnnn2C)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2cnnn2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2cnoc2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)-c2nccn2C)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)-c2cncn2C)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)-c2cnnn2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2nnn(C)n2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2nccn2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2nnnn2C)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2cncn2C)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-c2nnnn2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2cnnn2C)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2c(C)nn(C)c2C)ncc1C(F)(F)F |(-1.75,2.87,;-3.08,2.1,;-3.08,.56,;-1.75,-.21,;-1.75,-1.75,;-.41,-2.52,;.92,-1.75,;.92,-.21,;2.25,.56,;2.25,2.1,;.92,2.87,;3.59,-.21,;3.59,-1.75,;2.25,-2.52,;2.25,-4.06,;4.92,.56,;6.38,.08,;6.78,-1.41,;7.29,1.33,;6.38,2.57,;6.78,4.06,;4.92,2.1,;3.59,2.87,;-3.08,-2.52,;-4.42,-1.75,;-4.42,-.21,;-5.75,.56,;-7.29,.56,;-5.75,2.1,;-6.52,-.78,)|

CNc1nc(Nc2ccc(cc2OC)-c2ccnn2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2c(C)noc2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-n2cnnn2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2ccnn2C)ncc1C(F)(F)F

CCNc1nc(Nc2cc(F)c(cc2OC)-c2nnc(C)o2)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-c2nnc(C)o2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2nc(C)no2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2cnn(C)c2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2Cl)-c2nnc(C)o2)ncc1Cl

CNc1nc(Nc2ccc(cc2Cl)-c2nc(C)no2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)-c2cnn(C)c2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2nc(C)no2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)-c2nnc(C)o2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)-c2cn(C)nc2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2cnn(C)c2C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-c2nncn2C)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-c2cnn(C)c2C(=O)N(C)C)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-n2nnnc2C)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-c2cnnn2C)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-c2cnn(c2)C2COC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(C)c(cc2OC)-n2nnnc2C)ncc1C(F)(F)F

CNc1nc(Nc2cc(C)c(cc2OC)-n2nnnc2COC)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-n2nc(C)cc2COC)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)-n2nc(C)cc2COC)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)-n2nnnc2COC)ncc1C(F)(F)F

CNc1nc(Nc2cc3OCCN(C)C(=O)c3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cc3OC(C)(C)C(=O)N(C)c3cc2OC)ncc1Cl

CNc1nc(Nc2cc3oc(cc3cc2OC)C(=O)N(C)C)ncc1C(F)(F)F

CNc1nc(Nc2cc3n(C)c(=O)n(C)c3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cc3oc(=O)n(C)c3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cc3nc(C)oc3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cc3C(=O)N(C)Cc3cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3CN(C)C(=O)c3cc2Cl)ncc1Cl

CNc1nc(Nc2cc3CN(C)C(=O)c3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2ccc3C(=O)N(Cc3c2OC)C2CC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc3C(=O)N(C)Cc3c2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3OC(C)(C)C(=O)N(C)c3cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3oc(=O)[nH]c3cc2Cl)ncc1Cl

CNc1nc(Nc2cc3CCN(C)C(=O)c3cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3CCN(C)C(=O)c3cc2OC)ncc1C#N

CNc1nc(Nc2cc3cnn(C)c(=O)c3cc2OC)ncc1C(F)(F)F

CCN1Cc2c(ccc(Nc3ncc(c(NC)n3)C(F)(F)F)c2OC)C1=O

CNc1nc(Nc2ccc3C(=O)N(Cc3c2OC)C(C)(C)O)ncc1C(F)(F)F

CNc1nc(Nc2ccc3C(=O)N(Cc3c2OC)C2COC2)ncc1C(F)(F)F

CNc1nc(Nc2cc3CN(C)C(=O)c3cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3n(C)cc(C(=O)N4CCOCC4)c3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cc3CN(CC(C)(C)O)C(=O)c3cc2OC)ncc1C(F)(F)F

CCNc1nc(Nc2cc3CN(CC(C)(C)O)C(=O)c3cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3CN(C4COC4)C(=O)c3cc2OC)ncc1C(F)(F)F

CCNc1nc(Nc2cc3CN(C4COC4)C(=O)c3cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3n(C)cc(C(=O)N(C)C)c3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cc3n(C)cc(C(=O)N4CCNCC4)c3cc2Cl)ncc1C(F)(F)F

CCNc1nc(Nc2cc3n(C)cc(C(=O)N4CCOCC4)c3cc2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cc3n(C)cc(C(=O)N4CCOCC4)c3cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc3n(C)cc(C(=O)N4CCN(C)CC4)c3cc2Cl)ncc1C(F)(F)F

CCN1CCN(CC1)C(=O)c1cn(C)c2cc(Nc3ncc(c(NC)n3)C(F)(F)F)c(Cl)cc12

CNc1nc(Nc2cc3n(C)cc(C(=O)N4C[C@@H]5C[C@H]4CO5)c3cc2Cl)ncc1C(F)(F)F |r,TLB:13:15:21.20:18|

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(O)CC2)ncc1F

CNc1nc(Nc2ccc(cc2OC)C(=O)N(C)C)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)NC2CC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC(F)F)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN3CCCCC3C2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC(C)CC(C)C2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCCCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(F)(F)CC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN(CC2)C(C)=O)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCCC(C2)C(F)(F)F)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCCC2C)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN(CC2)S(C)(=O)=O)ncc1Cl

CCC1(CC)CN(CCO1)C(=O)c1ccc(Nc2ncc(Cl)c(NC)n2)c(OC)c1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2CO)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOC(CC(C)C)C2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCNCC2)ncc1Cl

CCOc1cc(ccc1Nc1ncc(Cl)c(NC)n1)C(=O)N1CCOCC1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(N)=O)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)NC(C)C)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2C3CCC2COC3)ncc1Cl

COc1cc(ccc1Nc1ncc(Cl)c(OC(C)C)n1)C(=O)N1CCOCC1

COc1cc(ccc1Nc1ncc(Cl)c(OC)n1)C(=O)N1CCOCC1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC3CC2CO3)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC3CCC(C2)O3)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)NCCCN)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C1CC1

COc1cc(ccc1Nc1ncc(Cl)c(NCC(C)C)n1)C(=O)N1CCOCC1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN(CC2)C(=O)C2CC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(CC2)C(C)(C)O)ncc1Br

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(C2)C(F)(F)F)ncc1Br

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(CC2)C#N)ncc1Br

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN(CC2)C2CCC2)ncc1Br

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN(CC(F)(F)F)CC2)ncc1Br

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(CC2)OC)ncc1Br

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC[C@@H](O)C2)ncc1Br |r|

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN(CC2)C2COC2)ncc1Br

CNc1nc(Nc2ccc(cc2OC(C)C)C(=O)N2CCOCC2)ncc1Cl

COc1cc(ccc1Nc1ncc(Cl)c(NCC2CC2)n1)C(=O)N1CCOCC1

COc1cc(ccc1Nc1ncc(Cl)c(NC2CCC2)n1)C(=O)N1CCOCC1

CNc1nc(Nc2ccc(cc2O)C(=O)N2CCOCC2)ncc1Cl

CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc(Br)c(OC)n2)c(OC)c1

COc1nc(Nc2ccc(cc2OC2CCC2)C(=O)N2CCOCC2)ncc1Br

CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1Cl

COc1cc(ccc1Nc1ncc(Br)c(OC)n1)C(=O)N1CC(C1)N1CCOCC1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC(C2)N2CCOCC2)ncc1Cl

COc1cc(ccc1Nc1ncc(Cl)c(NC2(C)CCC2)n1)C(=O)N1CCOCC1

COc1cc(ccc1Nc1ncc(Cl)c(NCC2CCOC2)n1)C(=O)N1CCOCC1

COc1cc(ccc1Nc1ncc(I)c(OC)n1)C(=O)N1CCOCC1

COc1cc(ccc1Nc1ncc(Cl)c(NCCC2CC2)n1)C(=O)N1CCOCC1

COCCNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl

COCCNc1nc(Nc2ccc(cc2OCC(F)(F)F)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2Cl)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1OC

COCCOc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Br

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N(C)C)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(N)=O)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NCCO)ncc1Cl

CNC(=O)c1cc(Cl)c(Nc2ncc(Cl)c(NC)n2)cc1OC

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(F)(F)CC2)ncc1Cl

CCNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOCC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2CC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NCCOC)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCNCC2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(CC2)N(C)C)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(O)C2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2COC2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2CC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2CCN(C)CC2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCCC2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC(C)(C)C)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N(C)C)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(O)CC2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOC(CO)C2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N(C)CCO)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCCOCC2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(CC2)C#N)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CC(O)C2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2(CC2)C#N)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(C2)C#N)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2C[C@H](C)N[C@H](C)C2)ncc1Cl |r|

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2COC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NCC(C)(C)O)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCNCC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(C2)C#N)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCC(C2)C#N)ncc1C(F)(F)F

CNC(=O)c1cc(OC)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N(C)CC(C)(C)O)ncc1C(F)(F)F

COc1cc(ccc1Nc1ncc(C2CC2)c(OC)n1)C(=O)N1CCOCC1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C(C)=O

COCCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1Br

COCCNc1nc(Nc2ccc(cc2OC(C)C)C(=O)N2CCOCC2)ncc1Br

COCCOc1nc(Nc2ccc(cc2OC2CCC2)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC2CCCC2)C(=O)N2CC3(COC3)C2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC3(COC3)C2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC(F)(F)OC(F)(F)C2)ncc1C#N

CNc1nc(Nc2ccc(cc2C2CC2)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(=O)NC2CC(F)(F)C2)ncc1C#N

CNc1nc(Nc2ccc(cc2OC)C(=O)NCC2CC2)ncc1C#N

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC[C@H](F)C2)ncc1C#N |r|

CNC(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1

CCN(CC)C(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1

CNc1nc(Nc2ccc(cc2OC)C(=O)NC(C)C)ncc1C#N

CCNC(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCCCC2)ncc1C#N

CNc1nc(Nc2ccc(cc2OC)C(=O)NCC(F)F)ncc1C#N

CNc1nc(Nc2ccc(cc2OC)C(=O)NC(C)(C)C)ncc1C#N

CCN(C(C)C)C(=O)c1ccc(Nc2ncc(C#N)c(NC)n2)c(OC)c1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(F)(F)C2)ncc1C#N

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC2)ncc1C#N

CNc1nc(Nc2ccc(cc2OC)C(=O)N(C)C(C)C)ncc1C#N

COc1cc(ccc1Nc1ncc(Cl)c(NC2CCOC2)n1)C(=O)N1CCOCC1

CNc1nc(Nc2ccc(cc2OC(C)C)C(=O)N2CCOCC2)ncc1C(F)(F)F

CCOc1cc(ccc1Nc1ncc(c(NC)n1)C(F)(F)F)C(=O)N1CCOCC1

CNc1nc(Nc2ccc(cc2OC2CC2)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC2CC2)C(=O)N2CCOCC2)ncc1Br

COc1cc(ccc1Nc1ncc(Cl)c(NCCS(C)(=O)=O)n1)C(=O)N1CCOCC1

CNc1nc(Nc2cc(OC)c(CC(=O)N3CCOCC3)cc2OC)ncc1Br

CNc1nc(Nc2cc(OC)c(CC(=O)N3CCOCC3)cc2OC)ncc1Cl

CNc1nc(Nc2ccc(CC(=O)N3CCOCC3)cc2OC)ncc1Cl

CNc1nc(Nc2ccc(CC(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F

COc1cc(CC(=O)N2CCOCC2)ccc1Nc1ncc(Br)c(OC)n1

CNc1nc(Nc2cc(OC)c(CC(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NCCCN)ncc1Cl

COCCNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Br

COC(C)CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2C)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2C)C(=O)N2CCC(O)CC2)ncc1Cl

CCNc1nc(Nc2ccc(cc2OC(F)(F)F)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC(F)(F)F)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2F)C(=O)N2CCOCC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(OC)c(cc2F)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N(C)C)ncc1C#N

CCNc1nc(Nc2ccc(C(=O)N3CCOCC3)c(F)c2OC)ncc1C(F)(F)F

CCNc1nc(Nc2ccc(C(=O)N3C[C@@H]4C[C@H]3CO4)c(F)c2OC)ncc1C(F)(F)F |r|

CNc1nc(Nc2ccc(cc2OC)C(=O)N2C[C@H](F)[C@@H](F)C2)ncc1C#N |r|

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCC(C2)OC)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCC(C2)OC)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N(C)CC(C)(C)O)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2C[C@H](C)O[C@H](C)C2)ncc1C(F)(F)F |r|

CCNc1nc(Nc2ccc(cc2OC(C)C)C(=O)N2CCOCC2)ncc1C(F)(F)F

COc1cc(ccc1Nc1ncc(Cl)c(n1)N1CCCCC1)C(=O)N1CCOCC1

COc1cc(ccc1Nc1ncc(Cl)c(n1)N1CCCC1)C(=O)N1CCOCC1

CCNc1c(cnc(n1)Nc2cc(c(cc2OC)C(=O)N3CCOCC3)F)C(F)(F)F

CCNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOCC2)ncc1Cl

COc1cc(C(=O)N2CCOCC2)c(F)cc1Nc1ncc(c(OC)n1)C(F)(F)F

COc1cc(Nc2ncc(Cl)c(OC)n2)c(Cl)cc1C(=O)N1CCOCC1

COc1nc(Nc2ccc(cc2Cl)C(=O)N2CCOCC2)ncc1Cl

COc1cc(C(=O)N2CCOCC2)c(Cl)cc1Nc1ncc(c(OC)n1)C(F)(F)F

COc1cc(ccc1Nc1ncc(c(OC)n1)C(F)(F)F)C(=O)N1CCOCC1

COc1cc(ccc1Nc1ncc(Cl)c(OC2CCOCC2)n1)C(=O)N1CCOCC1

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)NC2(CC2)C#N)ncc1C(F)(F)F

CNC(=O)c1cc(Cl)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1OC

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CC(C)OC(C)C2)ncc1C(F)(F)F

FC(F)(F)c1cnc(Nc2ccc(cc2Br)C(=O)N2CCOCC2)nc1N1CCCC1

CNc1nc(Nc2ccc(cc2OC2CCC2)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC(F)(F)C2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)NC2COC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC3CCC(C2)O3)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC3CC(C2)O3)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCCC2)ncc1C(F)(F)F

CCN(CC)C(=O)c1ccc(Nc2ncc(c(NC)n2)C(F)(F)F)c(OC)c1

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(CC2)N(C)C)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CC(C)OC(C)C2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(CC2)C#N)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCN(CC(F)(F)F)CC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCC(CC2)OC)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)NCCOC)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)NC2CCC(F)(F)CC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC2COC2)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OCC2CC2)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OCC2CCC2)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOCC2)ncc1Br

CNc1nc(Nc2ccc(cc2C2CC2)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2Br)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2Cl)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(Cl)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2cc(Cl)c(cc2OC)C(=O)N2CCOCC2)ncc1Cl

COc1cc(C(=O)N2CCOCC2)c(Cl)cc1Nc1ncc(Br)c(OC)n1

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOCC2)ncc1Cl

CNc1nc(Nc2cc(OC)c(cc2Cl)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(C(=O)N3CCOCC3)c(F)c2OC)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OCCF)C(=O)N2CCOCC2)ncc1C(F)(F)F

COc1cc(ccc1Nc1ncc(Cl)c(OC)n1)C(=O)N1CCCC1

CCOc1cc(C(=O)N2CCOCC2)c(F)cc1Nc1ncc(c(NC)n1)C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N(C)CCOC)ncc1C(F)(F)F

CCNc1nc(Nc2ccc(cc2OC)C(=O)N(C)CCOC)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N(C)CCOC)ncc1C(F)(F)F

CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N(C)CCOC)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCC[C@H]2COC)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCC[C@H]2COC)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N(CC)CCOC)ncc1C(F)(F)F

CCN(CCOC)C(=O)c1cc(OC)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1F

CCNc1nc(Nc2cc(F)c(cc2OCC)C(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C#N

COc1cc(ccc1Nc1ncc(C#N)c(OC)n1)C(=O)N1CCOCC1

CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1C#N

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1C#N

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2C[C@H](C)O[C@H](C)C2)ncc1C#N |r|

CCNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2C[C@H](C)O[C@H](C)C2)ncc1C#N |r|

CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N(C)C)ncc1C#N

CNc1nc(Nc2ccc(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)S(C)(=O)=O)ncc1Cl

CNc1nc(Nc2cc(F)c(cc2OC)C#N)ncc1C(F)(F)F

CNc1nc(Nc2c(OC)cc(cc2C(F)(F)F)C#N)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C#N)ncc1Cl

COc1nc(Nc2ccc(cc2Cl)S(C)(=O)=O)ncc1Cl

CNc1nc(Nc2ccc(cc2Cl)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2Cl)S(C)(=O)=O)ncc1Cl

CNc1nc(Nc2ccc(CN3CCOCC3)cc2OC)ncc1C(F)(F)F

CNc1nc(Nc2cc(C)c(cc2Cl)C#N)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C#N

CCNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C#N

CNc1nc(Nc2cc(C)c(cc2OC)C#N)ncc1C(F)(F)F

CNc1nc(Nc2ccc(CN3CCOCC3)cc2OCCF)ncc1Cl

CNc1nc(Nc2cc(F)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC(C)C)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OCCF)S(C)(=O)=O)ncc1Cl

COc1nc(Nc2ccc(cc2OCCF)S(C)(=O)=O)ncc1Cl

CNc1nc(Nc2ccc(cc2OCCF)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(Cl)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OCCF)ncc1C(F)(F)F

CCNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OCCF)ncc1C(F)(F)F

CNc1nc(Nc2cc(C)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)C(O)=O)ncc1Cl

CNc1nc(Nc2ccc(cc2OC)S(=O)(=O)N2CCOCC2)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(F)(F)F)ncc1C(F)(F)F

CNc1nc(Nc2ccc(cc2OC)C(F)(F)F)ncc1Cl

CNc1nc(Nc2cc(Cl)c(cc2OC)C(O)=O)ncc1Cl

CNc1nc(Nc2cc(F)c(cc2OC)N2CCCC2=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)N2CCOCC2=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)N2CCCCC2=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(F)c(cc2OC)C2COC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(C)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F

CCS(=O)(=O)c1cc(OC)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1C

CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C(F)(F)F

CCNc1nc(Nc2ccc(c3OCCOc23)S(C)(=O)=O)ncc1C(F)(F)F

Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1[nH]c2ncnc(N3CCOCC3)c2c1-c1cccc(c1)C#N

N#Cc1cccc(n1)-c1c[nH]c2ncnc(N3CCOCC3)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

CN(C)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

C[C@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12

C1CN(CCO1)c1ncnc2[nH]cc(-c3cn[nH]c3)c12

Cc1nc(N2CCOCC2)c2c(c[nH]c2n1)-c1cccc(c1)C#N

CN(C)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12

CC1(C)CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCCC3)c12

NC(=O)C1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12

O[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12 |r|

C1CCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12

OCC1CCN(CC1)c1ncnc2[nH]cc(-c3ccccc3)c12

OCc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC(C3)[N+]#[C-])c12

[C-]#[N+]C1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

C[C@H]1C[C@@H](C)CN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12 |r|

COc1ccc(cc1-c1c[nH]c2ncnc(N3CCCC(C)C3)c12)[N+]#[C-]

COc1ccc(cc1-c1c[nH]c2ncnc(N(C)C)c12)[N+]#[C-]

COc1ccc(Cl)cc1-c1c[nH]c2ncnc(N(C)C)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCC(CC3)c3ncc[nH]3)c12

COCC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CN1CCC2(CC1)CN(CCO2)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

COC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

COCC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CN(C)C(=O)CCNc1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

FC1(F)CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

FC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCC(CC3)c3cc[nH]n3)c12

F[C@H]1CCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |r|

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3cc[nH]n3)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC(C3)c3cc[nH]n3)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC(C3)c3ncc[nH]3)c12

CN1CCCC(C1)Nc1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

O=C1CC2(CN1)CCCN(C2)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(NCCN3CCOCC3)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC4(CCOC4)C3)c12

CC(=O)NC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc4[nH]ncc4c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)S(N)(=O)=O)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3F)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc4[nH]ncc34)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnc(F)c(C)c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc4C(=O)NCc4c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccnc3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cncc(C)c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnc4[nH]ccc4c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc4CNC(=O)c4c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnc4cc[nH]c4c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc(O)cc3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc(cc3)C(N)=O)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(O)c3)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cc(C)cnc3Cl)c12 |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C(N)=O)c12 |r|

FC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C(O)=O)c12 |r|

CNc1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

COc1ccc(cc1-c1c[nH]c2ncnc(N3C[C@@H](C)C[C@@H](C)C3)c12)C#N |r|

COc1ccc(cc1-c1c[nH]c2ncnc(N3CCC[C@H](C)C3)c12)C#N |r|

C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12 |r|

CN(C)c1ncnc2[nH]cc(-c3ccccc3)c12

CN(C)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC3)c12

CC1CCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CN(C)c1ncnc2[nH]cc(-c3cc(ccc3F)[N+]#[C-])c12

CCN(CC)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CN(C)c1ncnc2[nH]cc(-c3cc(F)cc(c3)C#N)c12

Fc1c(cccc1-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N

C[C@@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |r|

Fc1ccc(cc1-c1c[nH]c2ncnc(N3CCOCC3)c12)[N+]#[C-]

Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCC(F)CC3)c12

N#Cc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12

Clc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Fc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12

COc1cc(F)cc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Fc1ccc(F)c(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Fc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1F

Fc1ccc(Cl)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12

OCc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1F

Fc1ccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c(F)c1

Fc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Fc1cc(F)cc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

C1CN(CCO1)c1ncnc2[nH]cc(-c3ccccc3)c12

COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12

Clc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12

COc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

OCc1cc(ccc1F)-c1c[nH]c2ncnc(N3CCOCC3)c12

Fc1ccc(cc1)-c1c[nH]c2ncnc(N3CCOCC3)c12

OCc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

COc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12

CSc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

C1CN(CCO1)c1ncnc2[nH]cc(-c3cccnc3)c12

C1CN(CCO1)c1ncnc2[nH]cc(-c3cncc4ccccc34)c12

Brc1cncc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1ccc(Cl)c(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cn1ccc(n1)-c1c[nH]c2ncnc(N3CCOCC3)c12

OC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

Cc1noc(n1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

Cc1cc(cc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N

Cc1nc(no1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CC4CC(C3)O4)c12

Clc1cc(cc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N

COc1ccc(cc1-c1c[nH]c2ncnc(N3CCOCC3)c12)[N+]#[C-]

COc1ccc(Cl)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1[nH]c2ncnc(N3CCOCC3)c2c1-c1cnn(C)c1

COc1cc(cc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N

Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCSCC3)c12

Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCCC(O)C3)c12

C[C@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12 |r|

C[C@@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12 |r|

Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCCC(F)C3)c12

Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCOC(CO)C3)c12

Cc1ccc(OCC2CN(CCO2)c2ncnc3[nH]cc(-c4cnn(C)c4)c23)cn1

CN(C)c1ncnc2[nH]cc(-c3cnn(C)c3)c12

CN(C1CC1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12

FC1(F)CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

NC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

FC(F)c1nc(CC2CN(CCO2)c2ncnc3[nH]cc(-c4cccc(c4)C#N)c23)no1

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3nccs3)c12

O=C1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

OCC1(F)CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

Oc1cccc(c1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3noc(n3)C3CC3)c12

FC1(F)CCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(OCC2CN(CCO2)c2ncnc3[nH]cc(-c4cccc(c4)C#N)c23)c1

OC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

NC(=O)C1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CCC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3ccncn3)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3nc(no3)C3CC3)c12

CN(C)CC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(Nc3cn[nH]c3)c12

Cc1nc(CC2CN(CCO2)c2ncnc3[nH]cc(-c4cccc(c4)C#N)c23)no1

Cc1nnc(o1)C1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

COc1cc(cc(c1)-c1c[nH]c2ncnc(N(C)C)c12)C#N

CCn1cc(cn1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1cncc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Clc1cncc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

COc1cncc(n1)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1nn(C)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12

C[C@H]1COCCN1c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |r|

Cc1nc(N2CCOCC2)c2c(c[nH]c2n1)-c1cccc(C#N)c1F

O[C@@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12 |r|

OC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(F)c3)c12

COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCOC(C3)c3noc(C)n3)c12

FC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12

COc1ccccc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12

COc1cc(F)cc(c1)-c1c[nH]c2ncnc(N3CCC(F)CC3)c12

Cc1cncc(c1)-c1c[nH]c2ncnc(N3CCCC(O)C3)c12

COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12

COc1cc(F)cc(c1)-c1c[nH]c2ncnc(N3CCCC(O)C3)c12

COc1ccccc1-c1c[nH]c2ncnc(N3CCCC(O)C3)c12

Cc1noc(n1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12

COCC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12

COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC3)c12

C[C@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cncc(C)c3)c12 |r|

COc1ccccc1-c1c[nH]c2ncnc(N(C)C)c12

COc1ccccc1-c1c[nH]c2ncnc(N3CC[C@H](F)C3)c12 |r|

COc1ccccc1-c1c[nH]c2ncnc(N3CCCC3)c12

COc1cc(F)cc(c1)-c1c[nH]c2ncnc(N(C)C)c12

OC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12

COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCO[C@@H](C)C3)c12 |r|

C[C@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12 |r|

COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCCC(F)C3)c12

C[C@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(F)c3)c12 |r|

COc1ccc(F)cc1-c1c[nH]c2ncnc(N(C)C)c12

Fc1c(cccc1-c1c[nH]c2ncnc(N3CCCC3)c12)C#N

COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CC[C@H](F)C3)c12 |r|

Cc1nc(no1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12

Cc1ccnc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

COc1cccc(F)c1-c1c[nH]c2ncnc(N(C)C)c12 |(4.3,-1.64,;2.81,-1.24,;2.41,.25,;3.5,1.34,;3.1,2.83,;1.61,3.23,;.53,2.14,;-.96,2.54,;.92,.65,;-.17,-.44,;.74,-1.69,;-.17,-2.93,;-1.63,-2.46,;-2.96,-3.23,;-4.3,-2.46,;-4.3,-.92,;-2.96,-.15,;-2.96,1.39,;-1.63,2.16,;-4.3,2.16,;-1.63,-.92,)|

COc1cccc(F)c1-c1c[nH]c2ncnc(N3CCOCC3)c12 |(4.3,-2.26,;2.81,-1.86,;2.41,-.37,;3.5,.72,;3.1,2.2,;1.61,2.6,;.53,1.51,;-.96,1.91,;.92,.02,;-.17,-1.06,;.74,-2.31,;-.17,-3.56,;-1.63,-3.08,;-2.96,-3.85,;-4.3,-3.08,;-4.3,-1.54,;-2.96,-.77,;-2.96,.77,;-4.3,1.54,;-4.3,3.08,;-2.96,3.85,;-1.63,3.08,;-1.63,1.54,;-1.63,-1.54,)|

Cc1cc(sn1)-c1c[nH]c2ncnc(N3CCOCC3)c12

COc1ccc(F)c(Cl)c1-c1c[nH]c2ncnc(N3CCOCC3)c12 |(4.3,-2.38,;2.81,-1.98,;2.41,-.49,;3.5,.6,;3.1,2.08,;1.61,2.48,;1.22,3.97,;.53,1.39,;-.74,1.73,;.92,-.09,;-.17,-1.18,;.74,-2.43,;-.17,-3.68,;-1.63,-3.2,;-2.96,-3.97,;-4.3,-3.2,;-4.3,-1.66,;-2.96,-.89,;-2.96,.65,;-4.3,1.42,;-4.3,2.96,;-2.96,3.73,;-1.63,2.96,;-1.63,1.42,;-1.63,-1.66,)|

FC(F)c1[nH]c2ncnc(N3CCOCC3)c2c1-c1cccc(c1)C#N

C1CC=C(CO1)c1c[nH]c2ncnc(N3CCOCC3)c12 |c:2|

C1COC=C(C1)c1c[nH]c2ncnc(N3CCOCC3)c12 |c:3|

C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)-c3ncon3)c12

Cc1cc(on1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

Cc1c(cccc1-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N

O=c1cc(cc[nH]1)-c1c[nH]c2ncnc(N3CCOCC3)c12

C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4sccn34)c12

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3C[C@@H]4CCO[C@@H]4C3)c12 |r|

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3C[C@@H]4COC[C@@H]4C3)c12 |r|

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCO[C@H]4CCC[C@@H]34)c12 |r|

[C-]#[N+]C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

CC1(C)CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12

N#Cc1ccc(s1)-c1c[nH]c2ncnc(N3CCOCC3)c12

C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4cccnn34)c12

NC(=O)c1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12

C1CN(CCO1)c1ncnc2[nH]cc(-c3cnn4cccnc34)c12

Cn1cc(cc1C#N)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1nc2sccn2c1-c1c[nH]c2ncnc(N3CCOCC3)c12 |(-1.37,2.52,;-.04,1.75,;1.21,2.66,;2.45,1.75,;3.99,1.75,;4.47,.29,;3.22,-.62,;1.98,.29,;.44,.29,;-.33,-1.05,;.57,-2.29,;-.33,-3.54,;-1.8,-3.06,;-3.13,-3.83,;-4.47,-3.06,;-4.47,-1.52,;-3.13,-.75,;-3.13,.79,;-1.8,1.56,;-1.8,3.1,;-3.13,3.87,;-4.47,3.1,;-4.47,1.56,;-1.8,-1.52,)|

N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3ccno3)c12

Cn1cc(nc1C#N)-c1c[nH]c2ncnc(N3CCOCC3)c12

Cc1c(Nc2ncc(C#N)c(NC3CC3)n2)cnn1C1CCOCC1

CCNc1nc(Nc2cnn(C3CCOCC3)c2Cl)ncc1C#N

CNc1nc(Nc2cn(nc2C)C(C)(C)CO)ncc1C(F)(F)F

CNc1nc(Nc2cnn(CC3(O)CC3)c2Cl)ncc1C(F)(F)F

CCn1cnnc1C(C)(C)n1cc(Nc2ncc(c(NC)n2)C(F)(F)F)c(Cl)n1

CNc1nc(Nc2cn(nc2Cl)C(C)(C)c2ncn(C)n2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2Cl)C(C)(C)c2ncn(CC)n2)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C2(C)COC2)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C(C)(C)c2nc(C)cn2C)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C(C)(C)c2ncc(C)n2C)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C(C)(C)c2ncc(C)o2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C2(C)COC2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)S(=O)(=O)CCOC)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)S(=O)(=O)CCOC)ncc1C(F)(F)F

CNc1nc(Nc2cnn(c2C)S(=O)(=O)CCOC)ncc1C(F)(F)F

CCNc1nc(Nc2cnn(c2Cl)C(C)(C)c2nncn2C)ncc1C(F)(F)F

CNc1nc(Nc2cnn(CC(C)c3ccn(C)n3)c2C)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C(C)(C)c2ncccn2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2Cl)C(C)(C)c2nnc(C)o2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C(C)(C)c2nnc(CC)o2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C(C)(C)c2ncn(n2)C(C)C)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2Cl)C(C)(C)c2nncn2C)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2Cl)C(C)(C)c2ncn(C)n2)ncc1C(F)(F)F

CNc1nc(Nc2cnn(CCc3ccn(C)n3)c2C)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C(C)(C)c2ccn(C)n2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C(C)(C)c2ccnn2C)ncc1C(F)(F)F

CNc1nc(Nc2cn(CCc3ccn(C)n3)nc2C)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C2CCOC[C@H]2F)ncc1C(F)(F)F |r|

CNc1nc(Nc2cnn(C3CCOC[C@H]3F)c2C)ncc1C(F)(F)F |r|

CNc1nc(Nc2cnn(C3CCOC[C@@H]3F)c2C)ncc1C(F)(F)F |r|

CNc1nc(Nc2cn(nc2C)C(C)(C)CC#N)ncc1C(F)(F)F

CCC(Cn1cc(Nc2ncc(c(NC)n2)C(F)(F)F)c(C)n1)C#N

CCNc1nc(Nc2cc(nn2C)C(C)(C)C#N)ncc1C(F)(F)F

CNc1nc(Nc2cc(nn2C)C(C)(C)C#N)ncc1C(F)(F)F

Cc1nn(cc1Nc1ncc(C#N)c(NC2CC2)n1)C(C)(C)C#N

CCNc1nc(Nc2cc(nn2C)C#N)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCCCc23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCN(C)[C@@H](C)c23)ncc1C(F)(F)F |r|

CNc1nc(Nc2cnn3CCN(C)[C@H](C)c23)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cnn3CCN(C)[C@@H](C)c23)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cnn3CCN(C)[C@H](C)c23)ncc1C(F)(F)F |r|

C[C@@H]1N(C)CCn2ncc(Nc3ncc(c(NC4CC4)n3)C(F)(F)F)c12 |r|

C[C@H]1N(C)CCn2ncc(Nc3ncc(c(NC4CC4)n3)C(F)(F)F)c12 |r|

CNc1nc(Nc2cnn3c2C(C)OCC3(C)C)ncc1C(F)(F)F

CCNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCOCc23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CC(C)OC(C)c23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CC(C)(C)OCc23)ncc1C(F)(F)F

CCNc1nc(Nc2cnn3CC(C)(C)OCc23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCCc23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCN(C)c23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCN(C)Cc23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CCOC4(COC4)c23)ncc1C(F)(F)F

CNc1nc(Nc2cc3COCCn3n2)ncc1C(F)(F)F

COc1cc2ncnc(Nc3cccc(NS(=O)(=O)C=C)c3)c2cc1OC

COc1cc2ncnc(Nc3cccc(NS(C)(=O)=O)c3)c2cc1OC

CCCS(=O)(=O)Nc1cccc(Nc2ncnc3cc(OC)c(OC)cc23)c1

COc1cc2ncnc(Nc3cccc(NS(=O)(=O)CC(C)C)c3)c2cc1OC

COc1cc2ncnc(Nc3cccc(NS(=O)(=O)c4ccccc4)c3)c2cc1OC

COc1cc2ncnc(Nc3cccc(NS(=O)(=O)c4cccs4)c3)c2cc1OC

COc1cc2ncnc(Nc3cccc(NS(=O)(=O)CC(F)(F)F)c3)c2cc1OC

CCS(=O)(=O)Nc1cccc(Nc2ncnc3cc(OC)c(OC)cc23)c1

COc1cccc(c1)-c1ccnc2[nH]cc(C#N)c12

Cc1cccc(c1)-c1ccnc2[nH]cc(C#N)c12

CCc1cccc(c1)-c1ccnc2[nH]cc(C#N)c12

N#Cc1c[nH]c2nccc(-c3ccsc3)c12

N#Cc1c[nH]c2nccc(-c3ccc(CN4CCOCC4)cc3)c12

N#Cc1c[nH]c2nccc(-c3ccn(CN4CCOCC4)c3)c12

Cc1cc(ccc1CN1CCOCC1)-c1ccnc2[nH]cc(C#N)c12

CN(C)Cc1ccc(cc1C)-c1ccnc2[nH]cc(C#N)c12

CCc1cc(ccc1CN1CCOCC1)-c1ccnc2[nH]cc(C#N)c12

COc1cc(ccc1CN1CCOCC1)-c1ccnc2[nH]cc(C#N)c12

Nc1cc(-c2ccccc2)c2c(c[nH]c2n1)C#N

Cc1cccc(c1)-c1cc(N)nc2[nH]cc(C#N)c12

Cn1ccc(Nc2cc(-c3ccccc3)c3c(c[nH]c3n2)C#N)n1

Cc1cccc(c1)-c1cc(Nc2ccn(C)n2)nc2[nH]cc(C#N)c12

Cc1cc(ccc1CN1CCOCC1)-c1cc(Nc2ccn(C)n2)nc2[nH]cc(C#N)c12

Cn1cc(Nc2cc(-c3ccccc3)c3c(c[nH]c3n2)C#N)cn1

N#Cc1c[nH]c2nc(Nc3ccccn3)cc(-c3ccccc3)c12

Cc1cncc(c1)-c1cc(Nc2nn(C)cc2C(F)(F)F)nc2[nH]cc(C#N)c12

Cc1ccnc(c1)-c1cc(Nc2nn(C)cc2Cl)nc2[nH]cc(C#N)c12

Cc1cn(C)nc1Nc1cc(-c2cccc(C)n2)c2c(c[nH]c2n1)C#N

Cc1cccc(n1)-c1cc(Nc2nn(C)cc2C(F)(F)F)nc2[nH]cc(C#N)c12

Cc1cncc(c1)-c1cc(Nc2ccn(C)n2)nc2[nH]cc(C#N)c12

Cc1cn(C)nc1Nc1cc(-c2ccnc(C)c2)c2c(c[nH]c2n1)C#N

COc1cc(ccc1Nc1ccc2N(C)C(=O)c3ccccc3N(C)c2n1)C(=O)N1CCC(CC1)N1CCN(C)CC1

COc1cc(ccc1Nc1ccc2N(C)C(=O)c3ccccc3N(C)c2n1)C(=O)NC1CCN(C)CC1

CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1

CN1CCC(CC1)Nc1ncncc1-c1cnc2[nH]nc(C)c2c1

Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(F)cc4)C3)cc12

Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(F)c(F)c4)C3)cc12

Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)cc4)C3)cc12

Cc1n[nH]c2ncc(NC3CCCN(Cc4ccc(Cl)c(Cl)c4)C3)cc12

CN1CCN(CCOc2cncc(n2)-c2cnc3[nH]nc(C)c3c2)CC1

CN1CCC(CC1)C(=O)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1

Cc1n[nH]c2ncc(cc12)-c1cncc(Cl)n1

Cc1n[nH]c2ncc(cc12)-c1cnccn1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCCC1=O

CN1CCC(C1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCC(F)(F)C1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCN(CCO)CC1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCNCC1

CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1

CN(C)CCNc1cncc(n1)-c1cnc2[nH]nc(C)c2c1

CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]nc(C)c2c1

Cc1n[nH]c2ncc(cc12)-c1nccnc1N1CCCC1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCCCC1

Cc1n[nH]c2ncc(cc12)-c1cncc(NC2CCN(CCO)CC2)n1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCNC(=O)C1

CC(C)N1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]nc(C)c2c1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCc2ccccc12

Cc1n[nH]c2ncc(cc12)-c1cncc(Nc2cccc(c2)N2CCCC2=O)n1

CN1CCC(CC1)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1

CN1CCC(CC1)Nc1cccc(n1)-c1cnc2[nH]nc(C)c2c1

Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1

Cc1n[nH]c2ncc(cc12)-c1cnn(C)c1

CN(C)S(=O)(=O)c1cccc(c1)-c1cnc2[nH]nc(C)c2c1

CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1

Cn1cc(cn1)-c1cnc2[nH]ncc2c1

CCOC(=O)c1cccc(c1)-c1cnc2[nH]nc(C)c2c1

CN1CCN(Cc2cccc(c2)-c2cnc3[nH]nc(C)c3c2)CC1

CN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1

OCCN1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1

CN(C)CCNc1cncc(n1)-c1cnc2[nH]ccc2c1

C1CCN(C1)c1nccnc1-c1cnc2[nH]ccc2c1

CN1CC(C1)Nc1cncc(n1)-c1cnc2[nH]ccc2c1

O=C1CCCN1c1cncc(n1)-c1cnc2[nH]ccc2c1

O=C1CN(CCN1)c1cncc(n1)-c1cnc2[nH]ccc2c1

C1Cc2ccccc2N1c1cncc(n1)-c1cnc2[nH]ccc2c1

FC1(F)CCN(C1)c1cncc(n1)-c1cnc2[nH]ccc2c1

OC1CCN(CC1)c1cncc(n1)-c1cnc2[nH]ccc2c1

O=C(N1CCCCC1)c1cncc(n1)-c1cnc2[nH]ccc2c1

CN1CCN(CC1)C(=O)c1cncc(n1)-c1cnc2[nH]ccc2c1

CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]ccc2c1

CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]cc(Cl)c2c1

CN1CCC(CC1)Nc1cncc(n1)-c1cnc2[nH]cc(F)c2c1

CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]ccc2c1

CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(Cl)c2c1

CN(CC1CCOCC1)c1cncc(n1)-c1cnc2[nH]cc(F)c2c1

C1CN(CCO1)c1cncc(n1)-c1cnc2[nH]ccc2c1

Clc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1

Fc1c[nH]c2ncc(cc12)-c1cncc(n1)N1CCOCC1

CN1CCN(Cc2cccc(c2)-c2cnc3[nH]ccc3c2)CC1

Cc1n[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1

Cc1n[nH]c2ncc(cc12)-c1cccc(CC#N)c1

CN1CCN(CC1)c1ccc(cc1)-c1cnc2[nH]nc(C)c2c1

Cc1n[nH]c2ncc(Nc3cccc(CN4CCN(CCO)CC4)c3)cc12

CN1CCN(Cc2ccc(Nc3cnc4[nH]nc(C)c4c3)cc2)CC1

CN1CCN(CC1)c1ccc(Nc2cnc3[nH]nc(C)c3c2)cc1F

Cc1n[nH]c2ncc(Nc3cncc(Cl)n3)cc12

COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccsc1

COc1ccccc1-c1n[nH]c2ncc(cc12)-c1ccoc1

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(N)c(nnc2c1)C(N)=O

NC(=O)c1nnc2cc(ccc2c1N)-c1cccc(c1)N1CCOCC1

CN(C)c1ccc(cc1)-c1ccc2c(N)c(nnc2c1)C(N)=O

CN(C)c1cccc(c1)-c1ccc2c(N)c(nnc2c1)C(N)=O

NC(=O)c1nnc2cc(ccc2c1N)-c1ccc(cc1)N1CCOCC1

CC(C)(C)c1ccc2nnc(C(N)=O)c(N)c2c1

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#N

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CCC3)c(nnc2c1)C(N)=O

CN1CCC(CC1)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CCOC3)c(nnc2c1)C(N)=O

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CCOCC3)c(nnc2c1)C(N)=O

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3COC3)c(nnc2c1)C(N)=O

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CC3)c(nnc2c1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1cncnc1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1cnn(C)c1)C(N)=O

CC[C@@H](C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O |r|

CC[C@@H](C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#N

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)c1ccccc1 |r|

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CC1 |r|

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#N)C1CC1

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(F)cc1)C(N)=O

CCNc1c(nnc2cc(ccc12)-c1cccc(F)c1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1ccccc1F)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOCC1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1cccc(c1)N1CCOCC1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1cn[nH]c1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1cccnc1)C(N)=O

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC34CC5CC(CC(C5)C3)C4)c(nnc2c1)C(N)=O |TLB:23:18:25:22.24.21,23:22:25:19.18.17,17:18:16.25.24:21,THB:17:16:19.18.23:21,15:16:19.18.23:21|

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NCC3CCOCC3)c(nnc2c1)C(N)=O

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CCOCC1

CC(C)(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O

CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NCC3CC3)c(nnc2c1)C(N)=O

CCNc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O

CNc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O

CC(C)Nc1c(nnc2cc(C=C)ccc12)C(N)=O

COc1ccccc1-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O

COc1cccc(c1)-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O

COc1ccc(F)cc1-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)C(C)=C)C(N)=O

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)C1CC1 |r|

C[C@@H](Nc1c(nnc2cc(ccc12)-c1cnn(C)c1)C(N)=O)C1CC1

CN(C)C(=O)c1cccc(c1)-c1ccc2cc(nnc2c1)C(N)=O

COc1ccccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O

COCc1ccccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O

C[C@@H](Nc1c(nnc2cc(ccc12)-c1cncc2ccccc12)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc2NC(=O)Cc2c1)C(N)=O)C1CC1

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)C(=O)N(C)C

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1OC(F)(F)F)C(N)=O)C1CC1

COc1ccc(Br)cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1cccc(c1)S(C)(=O)=O)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(=O)n(C)c1)C(N)=O)C1CC1

NC(=O)c1cc2ccc(cc2nn1)-c1cccc(OCC2CC2)c1

CN(C)C(=O)c1ccc(cc1)-c1ccc2cc(nnc2c1)C(N)=O

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)S(C)(=O)=O

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOCC1=O)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1Cl)C(N)=O)C1CC1

COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)C(=O)N(C)C

C[C@@H](Nc1c(nnc2cc(ccc12)-c1cccc2NC(=O)Cc12)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc2CC(=O)Nc2c1)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1cccc2CC(=O)Nc12)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccn(C)c(=O)c1)C(N)=O)C1CC1

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1S(C)(=O)=O)C(N)=O)C1CC1

CC(C)Nc1c(nnc2ccc(cc12)-c1ccccc1)C(N)=O

CC(C)Nc1c(nnc2ccc(cc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O

CC(C)Nc1c(nnc2ccc(cc12)-c1ccncc1)C(N)=O

CC(C)Nc1c(nnc2ccc(cc12)-c1cn[nH]c1)C(N)=O

CC(C)Nc1c(nnc2ccc(cc12)-c1cn[nH]c1)C#N

CC(C)Nc1c(nnc2ccc(cc12)-c1cnn(C)c1)C(N)=O

CC(C)Nc1c(nnc2ccc(cc12)-c1nccs1)C(N)=O

CC(C)Nc1c(nnc2ccc(cc12)-c1cncs1)C(N)=O

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)c1ccccc1

C[C@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)c1ccccc1

CCC(CC)Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O

CC(Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)c1cccnc1

NC(=O)c1nnc2cc(ccc2c1NCCCO)-c1ccncc1

NC(=O)c1nnc2cc(ccc2c1NCCO)-c1ccncc1

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(Br)cc1OC

CCC(C)Sc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O

CC(C)Nc1c(I)nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1cscn1

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1ncco1

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1cccnc1

CC(C)Nc1c(Cl)nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1nccc(=O)[nH]1

CC(C)Nc1c(nnc2cc(Oc3ccccc3)ccc12)C(N)=O

CC(C)Nc1c(nnc2cc(Sc3ccccc3)ccc12)C(N)=O

CC(C)Nc1c(nnc2cc(Nc3ccccc3)ccc12)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-n1cccn1)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)N1CCCC1=O)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)N1CCN(C)CC1)C(N)=O

COc1ccccc1Nc1ccc2c(NC(C)C)c(nnc2c1)C(N)=O

COc1ncccc1Nc1ccc2c(NC(C)C)c(nnc2c1)C(N)=O

CC(C)Nc1c(nnc2ccc(cc12)N1CCOCC1)C(N)=O

COc1cccc(Nc2ccc3c(NC(C)C)c(nnc3c2)C(N)=O)c1

CC(C)Nc1c(nnc2cc(ccc12)-c1c[nH]nn1)C(N)=O

CC(C)Nc1c(C)nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O

CC(C)Nc1c(nnc2cc(CCO)ccc12)C(N)=O

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1nc[nH]n1

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)N1CCOC1=O

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-n1cccn1

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(cc1OC)N1CCOC1=O

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)N1CCOCC1=O

COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(cc1OC)N1CCOCC1=O

C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOC1=O)C(N)=O)C1CC1

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#C

COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ncccc1F

COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1nccnc1OC

COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1nccn1C

CNC(=O)c1nnc2cc(ccc2c1NC(C)C)-c1ccc(cc1)S(C)(=O)=O

CNC(=O)c1nnc2cc(ccc2c1NC)-c1ccc(cc1)S(C)(=O)=O

CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)-c1ccc(cc1)S(C)(=O)=O |r|

CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1ncc[nH]1

CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)C(C)=C

CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)C1CC1

CC(C)Oc1cc(F)c2[nH]nc(-c3ccnc(c3)N3CCOCC3)c2c1

Fc1cc(cc2c(n[nH]c12)-c1ccnc(c1)N1CCOCC1)-c1cnccn1

Cc1cc(cc2c(n[nH]c12)-c1ccnc(c1)N1CCOCC1)-c1cnn(C)c1

Cn1cc(cn1)-c1cc(Cl)c2[nH]nc(-c3ccnc(c3)N3CCOCC3)c2c1

Cn1cc(cn1)-c1cc(F)c2[nH]nc(-c3ccnc(c3)N3CC(F)C3)c2c1

Cc1cc(cc2c(n[nH]c12)-c1ccnc(c1)N1CCN(CC1)S(C)(=O)=O)-c1cnn(C)c1

Cc1cc(cc2c(n[nH]c12)-c1ccnc(c1)N1CC[C@@H](F)C1)-c1cnn(C)c1 |r|

C1C[C@H]2COc3cccc(c3)-c3cnn4ccc(NCCN2C1)nc34 |r|

Fc1ccc2NC[C@@H]3CCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2NCCN3CCC(CC3)Nc3ccn4ncc(-c1c2)c4n3 |(4.89,1.33,;3.8,.24,;4.2,-1.25,;3.11,-2.34,;1.62,-1.94,;.53,-3.03,;-1.35,-4.91,;-3.55,-4.33,;-3.55,-2.79,;-4.89,-2.02,;-4.89,-.48,;-3.55,.29,;-2.22,-.48,;-2.22,-2.02,;-3.55,1.83,;-2.22,2.6,;-2.22,4.14,;-.89,4.91,;.45,4.14,;1.91,4.61,;2.82,3.37,;1.91,2.12,;2.31,.64,;1.22,-.45,;.45,2.6,;-.89,1.83,)|

Fc1ccc2NC3CCN(CC3)CCNc3ccn4ncc(-c1c2)c4n3 |(4.62,1.74,;3.85,.41,;4.62,-.93,;3.85,-2.26,;2.31,-2.26,;1.44,-3.76,;-.86,-3.76,;-2.2,-4.53,;-3.53,-3.76,;-3.53,-2.22,;-2.2,-1.45,;-.86,-2.22,;-4.62,-1.13,;-3.53,-.04,;-3.93,1.45,;-2.59,2.22,;-2.59,3.76,;-1.26,4.53,;.07,3.76,;1.54,4.23,;2.44,2.99,;1.54,1.74,;2.31,.41,;1.54,-.93,;.07,2.22,;-1.26,1.45,)|

Fc1ccc2NCCN3CCCC3CCNc3ccn4ncc(-c1c2)c4n3

Fc1ccc2NCCCN3CCC(C3)Nc3ccn4ncc(-c1c2)c4n3

Fc1ccc2NC3CCN(CC3)CCOc3ccn4ncc(-c1c2)c4n3 |(4.89,1.01,;3.8,-.08,;4.2,-1.57,;3.11,-2.65,;1.62,-2.26,;.53,-3.35,;-1.82,-3.82,;-3.15,-4.59,;-4.49,-3.82,;-4.49,-2.28,;-3.15,-1.51,;-1.82,-2.28,;-4.89,-.8,;-3.55,-.03,;-3.55,1.51,;-2.22,2.28,;-2.22,3.82,;-.89,4.59,;.45,3.82,;1.91,4.3,;2.82,3.05,;1.91,1.81,;2.31,.32,;1.22,-.77,;.45,2.28,;-.89,1.51,)|

Fc1ccc2OC[C@@H]3CCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2NCCN3CCC(CC3)Oc3ccn4ncc(-c1c2)c4n3

Cc1cc(F)c-2cc1NC[C@@H]1CCCN1CCNc1ccn3ncc-2c3n1 |r|

CN1CCN2CCC[C@H]2COc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

F[C@@H]1C[C@H]2COc3ccc(F)c(c3)-c3cnn4ccc(NCCN2C1)nc34 |r|

Fc1ccc2NC[C@@H]3CCCN3CCCOc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2OC[C@@H]3CCCN3CCCNc3ccn4ncc(-c1c2)c4n3 |r|

CN1C2CCN(CC2)CCOc2ccc(F)c(c2)-c2cnn3ccc1nc23

CN1CCN2CCC[C@H]2CNc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

Fc1ccc2OC[C@@H]3CCCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2O[C@@H]3CCCCN(C3)CCNc3ccn4ncc(-c1c2)c4n3 |r|

CN1CCN2CCCC[C@H]2COc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

Fc1ccc2OC[C@@H]3CNCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2NC[C@@H]3CCCN3CCOc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2OC[C@@H]3COCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

CN1CCN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2C1)ccc5F)c4n3 |r|

CN1CCN2CCN(C)c3ccn4ncc(-c5cc(OC[C@@H]2C1)ccc5F)c4n3 |r|

CN1CCN2CCOC[C@H]2COc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

Fc1cc(Cl)c2OC[C@@H]3CCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2OC[C@@H]3CN4CCC[C@@H]4CN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2O[C@@H]3CNCCN(C3)CCNc3ccn4ncc(-c1c2)c4n3 |r|

CN1CCN2C[C@H]3CCCN3C[C@H]2COc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

Fc1ccc2OC[C@H]3CN4CCC[C@@H]4CN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

CN1CCN2C[C@@H]3CCCN3C[C@@H](C2)Oc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

CC(=O)N1CCN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2C1)ccc5F)c4n3 |r|

Fc1ccc2OC3CCN(CC3)CCNc3ccn4ncc(-c1c2)c4n3 |(5.09,1.17,;4,.08,;4.4,-1.41,;3.31,-2.5,;1.82,-2.1,;.73,-3.19,;-2.51,-4.35,;-4,-4.75,;-5.09,-3.66,;-4.69,-2.18,;-3.2,-1.78,;-2.11,-2.87,;-4.69,-.64,;-3.35,.13,;-3.35,1.67,;-2.02,2.44,;-2.02,3.98,;-.69,4.75,;.65,3.98,;2.11,4.46,;3.02,3.21,;2.11,1.97,;2.51,.48,;1.42,-.61,;.65,2.44,;-.69,1.67,)|

CN1CCN2CCC(CC2)Oc2ccc(F)c(c2)-c2cnn3ccc1nc23 |(-4.69,2.44,;-3.35,1.67,;-3.35,.13,;-4.69,-.64,;-4.69,-2.18,;-5.09,-3.66,;-4,-4.75,;-2.51,-4.35,;-2.11,-2.87,;-3.2,-1.78,;.73,-3.19,;1.82,-2.1,;3.31,-2.5,;4.4,-1.41,;4,.08,;5.09,1.17,;2.51,.48,;1.42,-.61,;2.11,1.97,;3.02,3.21,;2.11,4.46,;.65,3.98,;-.69,4.75,;-2.02,3.98,;-2.02,2.44,;-.69,1.67,;.65,2.44,)|

Fc1ccc2OC[C@H]3CNCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

CN1CCN2CCNc3ccn4ncc(-c5cc(OC[C@H]2C1)ccc5F)c4n3 |r|

Fc1ccc2OC[C@@H]3CCCN3CCCc3ccn4ncc(-c1c2)c4n3 |r|

Fc1ccc2OC[C@@H]3CN4CCC[C@H]4CN3CCNc3ccn4ncc(-c1c2)c4n3 |r|

F[C@H]1C[C@H]2COc3ccc(F)c(c3)-c3cnn4ccc(NCCN2C1)nc34 |r|

C[C@H]1C[C@@H]2CCN1CCNc1ccn3ncc(-c4cc(O2)ccc4F)c3n1 |r|

Fc1ccc2OC[C@@H]3C=CCCN3CCNc3ccn4ncc(-c1c2)c4n3 |r,c:8|

CN1CCN2C[C@@H]3CCCN3C[C@H]2COc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

Fc1ccc2O[C@@H]3CN4CCC[C@H]4CN(C3)CCNc3ccn4ncc(-c1c2)c4n3 |r|

CN1CCN2C[C@@H]3CCCN3C[C@H](C2)Oc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

C[C@@H]1CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1)ccc5F)c4n3 |r|

C[C@@H]1CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1C)ccc5F)c4n3 |r|

C[C@@H]1CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1C1CC1)ccc5F)c4n3 |r|

CCCN1C[C@H]2COc3ccc(F)c(c3)-c3cnn4ccc(NCCN2C[C@H]1C)nc34 |r|

C[C@@H]1CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1CC1CC1)ccc5F)c4n3 |r|

CCN1C[C@H]2COc3ccc(F)c(c3)-c3cnn4ccc(NCCN2C[C@H]1C)nc34 |r|

CC(C)[C@H]1CN2C[C@@H](CN1)Oc1ccc(F)c(c1)-c1cnn3ccc(NCC2)nc13 |r|

Fc1ccc2OC[C@@H]3CCCN3CCNc3ccc4ncc(-c1c2)n4n3 |r|

C[C@H]1CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1)ccc5F)c4n3 |r|

C[C@H]1CN2C[C@@H](CN1)Oc1ccc(F)c(c1)-c1cnn3ccc(NCC2)nc13 |r|

CC1(C)CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1)ccc5F)c4n3 |r|

CC(C)[C@H]1CN2CCN(C)c3ccn4ncc(-c5cc(OC[C@@H]2CN1)ccc5F)c4n3 |r|

Fc1ccc2OCCN3CCC[C@@H](C3)Nc3ccn4ncc(-c1c2)c4n3 |r|

CC1(C)CN2C[C@@H](CN1)Oc1ccc(F)c(c1)-c1cnn3ccc(NCC2)nc13 |r|

Fc1ccc2O[C@@H]3CCCCN(C3)CCNc3ccc4ncc(-c1c2)n4n3 |r|

Fc1ccc2OCCN3CC[C@H](C3)Nc3ccn4ncc(-c1c2)c4n3 |r|

CN1[C@@H]2CCN(C2)CCOc2ccc(F)c(c2)-c2cnn3ccc1nc23 |r|

CC1(C)CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1C1CC1)ccc5F)c4n3 |r|

CC1(C)CN2CCNc3ccn4ncc(-c5cc(OC[C@@H]2CN1CC=C)ccc5F)c4n3 |r|

CNc1nc(Nc2cnn(C3CC4CCC(C3)N4C)c2C)ncc1C(F)(F)F |TLB:18:17:13.14:11.16.10,THB:9:10:17:13.14|

CNc1nc(Nc2cn(nc2C)C2CC3CCC(C2)N3C)ncc1C(F)(F)F |TLB:20:19:15.16:13.18.12,THB:8:12:19:15.16|

CNc1nc(Nc2cn(nc2C)C2C[C@@H]3C[C@@H]3C2)ncc1C(F)(F)F |r|

CNc1nc(Nc2cnn(C3C[C@@H]4C[C@@H]4C3)c2C)ncc1C(F)(F)F |r|

Cc1nn(cc1Nc1ncc(c(NC2C3CC2C3)n1)C(F)(F)F)C(C)(C)C#N |(-4.47,-1.87,;-2.93,-1.87,;-2.02,-3.12,;-.56,-2.64,;-.56,-1.1,;-2.02,-.63,;-2.42,.86,;-1.33,1.95,;-1.73,3.44,;-.64,4.53,;.85,4.13,;1.25,2.64,;2.73,2.24,;3.13,.76,;2.36,-.58,;3.7,-1.35,;4.47,-.01,;3.58,-.9,;.16,1.55,;1.94,5.22,;3.42,4.82,;1.54,6.71,;3.03,6.31,;.53,-3.73,;2.02,-4.13,;1.62,-2.64,;.13,-5.22,;-.26,-6.71,)|

CNc1nc(Nc2cn(CC34CC(C3)(C4)C#N)nc2C)ncc1C(F)(F)F

CNc1nc(Nc2cnn(CC34CC(C3)(C4)C#N)c2C)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CC4(CC4)Cc23)ncc1C(F)(F)F

CNc1nc(Nc2cnn(C3C[C@H]4[C@@H](C3)C4(F)F)c2Cl)ncc1C(F)(F)F |r|

CNc1nc(Nc2cn(nc2Cl)C2C[C@H]3[C@@H](C2)C3(F)F)ncc1C(F)(F)F |r|

CNc1nc(Nc2cnn(C3C[C@H]4[C@@H](C3)C4(F)F)c2C)ncc1C(F)(F)F |r|

CNc1nc(Nc2cn(nc2C)C2C[C@H]3[C@@H](C2)C3(F)F)ncc1C(F)(F)F |r|

CNc1nc(Nc2cnn(C3CC4(COC4)C3)c2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C(C)(C)c2ncn(C)n2)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C(C)(C)c2ccn(C)n2)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CC4(COC4)Cc23)ncc1C(F)(F)F

CNc1nc(Nc2cnn3CC4(CC4)COc23)ncc1C(F)(F)F

Cc1nn(cc1Nc1nc2NCC3(CC3)c2c(n1)C1CC1)C(C)(C)C#N

CCNc1nc(Nc2cnn3CC4(COC4)Cc23)ncc1C(F)(F)F

Cc1c(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cnn1C1C[C@@H](C1)C#N |r,wU:23.28,(-3.98,.54,;-2.5,.14,;-1.25,1.05,;-1.25,2.59,;.08,3.36,;.08,4.9,;1.42,5.67,;2.75,4.9,;2.75,3.36,;4.09,2.59,;4.09,1.05,;3.32,-.29,;4.86,-.29,;1.42,2.59,;4.09,5.67,;5.42,4.9,;4.09,7.21,;5.42,6.44,;-0,.14,;-.48,-1.32,;-2.02,-1.32,;-2.79,-2.65,;-4.28,-3.05,;-3.88,-4.54,;-2.39,-4.14,;-4.65,-5.87,;-5.42,-7.21,)|

CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C2CCN(C)C2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cnn(C3C[C@@H](C3)C#N)c2C)ncc1C(F)(F)F |r,wU:13.15,(5.42,.28,;4.09,1.05,;4.09,2.59,;2.75,3.36,;1.42,2.59,;.08,3.36,;-1.25,2.59,;-1.25,1.05,;-0,.14,;-.48,-1.32,;-2.02,-1.32,;-2.79,-2.65,;-4.28,-3.05,;-3.88,-4.54,;-2.39,-4.14,;-4.65,-5.87,;-5.42,-7.21,;-2.5,.14,;-3.98,.54,;.08,4.9,;1.42,5.67,;2.75,4.9,;4.09,5.67,;5.42,4.9,;4.09,7.21,;5.42,6.44,)|

CNc1nc(Nc2cnn(C3CN(CCC3(F)F)C3COC3)c2Cl)ncc1C(F)(F)F

CNc1nc(Nc2cnn(C3CCCC3(C)O)c2C)ncc1C(F)(F)F

CCNc1nc(Nc2cnn(C3CCC3)c2C#N)ncc1C(F)(F)F

COc1nc(Nc2cn(nc2C)C(C)(C)c2ncn(C)n2)ncc1Br

CCNc1nc(Nc2cc(nn2C)C(C)(C)n2nccn2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)[C@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F |r,wU:15.18,wD:13.13,(4.7,.38,;3.37,1.15,;3.37,2.69,;2.03,3.46,;.7,2.69,;-.63,3.46,;-1.97,2.69,;-1.97,1.15,;-.72,.25,;-1.2,-1.22,;-2.74,-1.22,;-3.21,.25,;-4.7,.65,;-.43,-2.55,;-.83,-4.04,;.67,-4.46,;1.06,-2.95,;1.44,-5.79,;2.21,-7.13,;-.63,5,;.7,5.77,;2.08,5.03,;3.42,5.8,;4.75,6.57,;2.65,7.13,;4.19,4.47,)|

CCNc1nc(Nc2cn(nc2C)[C@@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F |r,wD:13.13,15.18,(4.7,.38,;3.37,1.15,;3.37,2.69,;2.03,3.46,;.7,2.69,;-.63,3.46,;-1.97,2.69,;-1.97,1.15,;-.72,.25,;-1.2,-1.22,;-2.74,-1.22,;-3.21,.25,;-4.7,.65,;-.43,-2.55,;1.06,-2.95,;.67,-4.46,;-.83,-4.04,;1.44,-5.79,;2.21,-7.13,;-.63,5,;.7,5.77,;2.08,5.03,;3.42,5.8,;4.75,6.57,;2.65,7.13,;4.19,4.47,)|

COc1nc(Nc2cnn(C3CCC3)c2C#N)ncc1Br

Cc1nn(cc1Nc1ncc(c(NC2CC2)n1)C(F)(F)F)C(C)(C)C#N

Cc1nn(cc1Nc1ncc(c(N[C@H]2C[C@H]2F)n1)C(F)(F)F)C(C)(C)C#N |r|

Cc1c(cn(n1)C(C)(C)C#N)Nc2ncc(c(n2)NC)C(F)(F)F

COc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1Br

CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1Br

CCNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1Br

CCNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F

Cc1nn(cc1Nc1ncc(c(NCC(F)F)n1)C(F)(F)F)C(C)(C)C#N

CCNc1nc(Nc2cnn3CC(F)Cc23)ncc1C(F)(F)F

CCNc1nc(Nc2cnn3CC(Cc23)C#N)ncc1C(F)(F)F

CCNc1nc(Nc2cnn3CC(Cc23)n2nccn2)ncc1C(F)(F)F

Cc1nn(cc1Nc1ncc(Cl)c(OC2CC2)n1)C(C)(C)C#N

CCNc1nc(Nc2cnn3CC(Cc23)n2ccnn2)ncc1C(F)(F)F

COc1nc(Nc2cn(nc2C)C2(C)CCNC2=O)ncc1Br

COc1nc(Nc2cnn(c2C)C2(C)CCNC2=O)ncc1Br

Cc1nn(cc1Nc1ncc(Br)c(NC2CC2)n1)C(C)(C)C#N

Cn1nc(cc1Nc1ncc(c(NC2CC2)n1)C(F)(F)F)C(C)(C)n1nccn1

Cc1nn(cc1Nc1ncc(Cl)c(NC2CC2)n1)C(C)(C)C#N

Cc1nn(cc1Nc1ncc(Br)c(NCC(F)F)n1)C(C)(C)C#N

CCNc1nc(Nc2cc(nn2C)C(C)(C)n2nccn2)ncc1Br

Cc1nn(cc1Nc1ncc(c(NC(CF)CF)n1)C(F)(F)F)C(C)(C)C#N

CNc1nc(Nc2cc(nn2C2CC2)C(C)(C)n2nccn2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)n2nccn2)ncc1C(F)(F)F

Cn1nc(cc1Nc1ncc(Br)c(NC2CC2)n1)C(C)(C)n1nccn1

Cn1nc(cc1Nc1ncc(Br)c(OC2CC2)n1)C(C)(C)n1nccn1

CCNc1nc(Nc2cc(nn2C)C(C)(C)c2ncco2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(n(C)n2)C(C)(C)c2ncco2)ncc1C(F)(F)F

Cc1nn(cc1Nc1ncc(c(NC2(C)CC2)n1)C(F)(F)F)C(C)(C)C#N

CCNc1nc(Nc2cn(nc2C)C(C)(C)c2nncs2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C(C)(C)C)C(C)(C)n2nccn2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2CC)C(C)(C)n2nccn2)ncc1C(F)(F)F

COc1nc(Nc2cn(nc2C)C2(C)CCOC2=O)ncc1Br

CCNc1nc(Nc2cn(nc2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cnn(C3CCCN(CC(F)F)C3)c2C)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C2CC2)C(C)(C)C#N)ncc1Br

CCNc1nc(Nc2cn(Cc3ccon3)nc2C2CC2)ncc1C(F)(F)F

COc1nc(Nc2cn(Cc3cc[nH]n3)nc2C2CC2)ncc1Br

CCNc1nc(Nc2cn(nc2C2CC2)C2CS(=O)(=O)C2)ncc1Br

CCNc1nc(Nc2cnn(C3C[C@@H](C3)n3nccn3)c2C2CC2)ncc1C(F)(F)F |r,wU:13.15,(6.04,.8,;4.71,1.57,;4.71,3.11,;3.37,3.88,;2.04,3.11,;.71,3.88,;-.63,3.11,;-.63,1.57,;.62,.66,;.14,-.8,;-1.4,-.8,;-2.17,-2.14,;-3.65,-2.54,;-3.26,-4.02,;-1.77,-3.62,;-4.03,-5.36,;-5.57,-5.36,;-6.04,-6.82,;-4.8,-7.73,;-3.55,-6.82,;-1.87,.66,;-3.36,1.06,;-4.45,2.15,;-4.85,.66,;.71,5.42,;2.04,6.19,;3.37,5.42,;4.71,6.19,;6.04,5.42,;4.71,7.73,;6.04,6.96,)|

CCNc1nc(Nc2cnn(c2Cl)-c2cnccn2)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2Cl)C2(C)CCOC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C2(C)CCOC2=O)ncc1C(F)(F)F

Cc1nn(cc1Nc1ncc(c(n1)C1CC1)C(F)(F)F)C1(C)CCOC1=O

CCNc1nc(Nc2cnn(c2C2CC2)-c2cnccn2)ncc1C(F)(F)F

CCNc1nc(Nc2cnn(C3C[C@@H](C3)N3CCN(CC(F)F)CC3)c2C)ncc1C(F)(F)F |r,wU:13.15,(6.19,2.95,;4.86,3.72,;4.86,5.26,;3.52,6.03,;2.19,5.26,;.85,6.03,;-.48,5.26,;-.48,3.72,;.77,2.81,;.29,1.35,;-1.25,1.35,;-2.02,.01,;-3.51,-.39,;-3.11,-1.87,;-1.62,-1.48,;-3.88,-3.21,;-5.42,-3.21,;-6.19,-4.54,;-5.42,-5.87,;-6.19,-7.21,;-5.42,-8.54,;-6.19,-9.88,;-3.88,-8.54,;-3.88,-5.87,;-3.11,-4.54,;-1.73,2.81,;-3.21,3.21,;.85,7.57,;2.19,8.34,;3.52,7.57,;4.86,8.34,;4.86,9.88,;6.19,7.57,;6.19,9.11,)|

CCNc1nc(Nc2cn(nc2C2CC2)C2C[C@@H]2C#N)ncc1C(F)(F)F |r|

CNc1nc(Nc2c[nH]nc2C)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C2CC2)C2CS(=O)(=O)C2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C2CC2)S(C)(=O)=O)ncc1Br

CCNc1nc(Nc2cn(nc2C2CC2)S(C)(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C2CC2)C2(C)CCOC2=O)ncc1Br

CCNc1nc(Nc2cn(nc2Cl)C2(C)CCOC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C2CC2)C(C)(C)C#N)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C2(C)CCOC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)n2nccn2)ncc1Br

CCNc1nc(Nc2cc(nn2C2CCC2)C(C)(C)n2nccn2)ncc1C(F)(F)F

CNc1nc(Nc2cc(nn2C2CC2)C(C)(C)c2ncccn2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(=O)N(C)C)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)C#N)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)S(C)(=O)=O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C#N)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)=O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCC(=O)N2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)n2nccn2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)S(C)(=O)=O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)S(C)(=O)=O)ncc1Br

CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)C#N)ncc1Br

CCNc1nc(Nc2cc(nn2C2CC2)-c2ncoc2C)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C2(C)COC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C(C)n2nccn2)ncc1Br

CCNc1nc(Nc2cc(nn2C2CC2)C2(C)COC2)ncc1Br

CCNc1nc(Nc2cc(CN3CCCC3=O)nn2C2CC2)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br

CCNc1nc(Nc2cc(nn2C2CC2)[C@H]2C[C@@H]2C#N)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C2CC2)N2CCCC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)N2CCCS2(=O)=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F

COc1nc(Nc2cc(nn2C2CC2)C(C)(C)n2nccn2)ncc1Br

CCNc1nc(Nc2cc(nn2C2CC2)N2CCCC2=O)ncc1Br

CCNc1nc(Nc2cc(nn2C2CC2)N2CCCS2(=O)=O)ncc1Br

COc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CC2)[C@@]23C[C@@H]2COC3=O)ncc1C(F)(F)F |r|

CNc1nc(Nc2cc(nn2C2CC2)[C@@]23C[C@@H]2COC3=O)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C2CC2)[C@H]2C[C@H]2C#N)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C2CC2)[C@]23C[C@H]2COC3=O)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCn3ccnc23)ncc1C(F)(F)F

CNc1nc(Nc2cc(nn2C2CC2)[C@]23C[C@H]2COC3=O)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C2CC2)[C@H]2C[C@H]2C(=O)OCC)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C2CC2)[C@H]2C[C@H]2C(N)=O)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCn3ncnc23)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C)C2(C)CCOC2=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(nn2C)C2(C)CCOC2=O)ncc1C(F)(F)F

CNc1nc(Nc2cc(nn2C)C2(C)CCn3ccnc23)ncc1C(F)(F)F

CCNc1nc(Nc2ccnn2[C@@H]2C[C@H](O)C2)ncc1C(F)(F)F |r,wU:12.12,14.15,(6.5,-2.67,;5.16,-1.9,;5.16,-.36,;3.83,.41,;2.5,-.36,;1.16,.41,;-.17,-.36,;-.17,-1.9,;1.07,-2.8,;.6,-4.26,;-.94,-4.26,;-1.42,-2.8,;-2.91,-2.4,;-3.68,-1.07,;-5.01,-1.84,;-6.5,-1.44,;-4.24,-3.17,;1.16,1.95,;2.5,2.72,;3.83,1.95,;5.16,2.72,;5.16,4.26,;6.5,1.95,;6.5,3.49,)|

CCNc1nc(Nc2ccnn2[C@H]2C[C@H](O)C2)ncc1C(F)(F)F |r,wU:12.12,wD:14.15,(6.5,-2.67,;5.16,-1.9,;5.16,-.36,;3.83,.41,;2.5,-.36,;1.16,.41,;-.17,-.36,;-.17,-1.9,;1.07,-2.8,;.6,-4.26,;-.94,-4.26,;-1.42,-2.8,;-2.91,-2.4,;-4.24,-3.17,;-5.01,-1.84,;-6.5,-1.44,;-3.68,-1.07,;1.16,1.95,;2.5,2.72,;3.83,1.95,;5.16,2.72,;5.16,4.26,;6.5,1.95,;6.5,3.49,)|

CCNc1nc(Nc2ccnn2[C@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F |r,wU:12.12,wD:14.17,(7.24,-2.67,;5.91,-1.9,;5.91,-.36,;4.57,.41,;3.24,-.36,;1.91,.41,;.57,-.36,;.57,-1.9,;1.82,-2.8,;1.34,-4.26,;-.2,-4.26,;-.67,-2.8,;-2.16,-2.4,;-3.5,-3.17,;-4.27,-1.84,;-2.93,-1.07,;-5.75,-1.44,;-7.24,-1.04,;1.91,1.95,;3.24,2.72,;4.57,1.95,;5.91,2.72,;5.91,4.26,;7.24,1.95,;7.24,3.49,)|

CCNc1nc(Nc2ccnn2[C@H]2C[C@@H](C2)n2nccn2)ncc1C(F)(F)F |r,wU:12.12,wD:14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.99,-3.17,;-3.76,-1.84,;-2.43,-1.07,;-5.25,-1.44,;-5.73,.03,;-7.27,.03,;-7.74,-1.44,;-6.5,-2.34,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)|

CCNc1nc(Nc2ccnn2[C@H]2C[C@@H](C2)n2ccnn2)ncc1C(F)(F)F |r,wU:12.12,wD:14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.99,-3.17,;-3.76,-1.84,;-2.43,-1.07,;-5.25,-1.44,;-5.73,.03,;-7.27,.03,;-7.74,-1.44,;-6.5,-2.34,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)|

CCNc1nc(Nc2cc(nn2C)[C@@]23C[C@@H]2COC3=O)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C)[C@]23C[C@H]2COC3=O)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cc(nn2C)C2(C)CCCO2)ncc1C(F)(F)F

CCNc1nc(Nc2ccnn2[C@@H]2C[C@@H](C2)n2nccn2)ncc1C(F)(F)F |r,wU:12.12,14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.43,-1.07,;-3.76,-1.84,;-2.99,-3.17,;-5.25,-1.44,;-5.73,.03,;-7.27,.03,;-7.74,-1.44,;-6.5,-2.34,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)|

CCNc1nc(Nc2ccnn2[C@@H]2C[C@@H](C2)n2ccnn2)ncc1C(F)(F)F |r,wU:12.12,14.17,(7.74,-2.67,;6.41,-1.9,;6.41,-.36,;5.08,.41,;3.74,-.36,;2.41,.41,;1.07,-.36,;1.07,-1.9,;2.32,-2.8,;1.84,-4.26,;.3,-4.26,;-.17,-2.8,;-1.66,-2.4,;-2.43,-1.07,;-3.76,-1.84,;-2.99,-3.17,;-5.25,-1.44,;-6.5,-2.34,;-7.74,-1.44,;-7.27,.03,;-5.73,.03,;2.41,1.95,;3.74,2.72,;5.08,1.95,;6.41,2.72,;6.41,4.26,;7.74,1.95,;7.74,3.49,)|

CCNc1nc(Nc2ccnn2[C@H]2C[C@H](F)C2)ncc1C(F)(F)F |r,wU:12.12,wD:14.15,(6.5,-2.67,;5.16,-1.9,;5.16,-.36,;3.83,.41,;2.5,-.36,;1.16,.41,;-.17,-.36,;-.17,-1.9,;1.07,-2.8,;.6,-4.26,;-.94,-4.26,;-1.42,-2.8,;-2.91,-2.4,;-4.24,-3.17,;-5.01,-1.84,;-6.5,-1.44,;-3.68,-1.07,;1.16,1.95,;2.5,2.72,;3.83,1.95,;5.16,2.72,;5.16,4.26,;6.5,1.95,;6.5,3.49,)|

CCNc1nc(Nc2cc(nn2C2CCC2)C(C)(C)O)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C2CCC2)C(C)(C)OC)ncc1C(F)(F)F

CCNc1nc(Nc2cc(nn2C)C2CCOCC2)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2C)C2(C)CCCC2=O)ncc1C(F)(F)F

CNc1nc(Nc2cn(nc2C)C2(C)CCCC2=O)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2[C@H]2C[C@@H](C2)n2nccn2)C2CC2)ncc1C(F)(F)F |r,wU:12.12,wD:14.17,(8.41,1.08,;7.08,1.85,;5.74,1.08,;4.41,1.85,;3.07,1.08,;1.74,1.85,;.41,1.08,;.41,-.46,;1.65,-1.36,;1.18,-2.83,;-.36,-2.83,;-.84,-1.36,;-2.33,-.96,;-3.66,-1.73,;-4.43,-.4,;-3.1,.37,;-5.92,-0,;-6.39,1.46,;-7.93,1.46,;-8.41,-0,;-7.16,-.91,;1.95,-4.16,;1.95,-5.7,;3.28,-4.93,;1.74,3.39,;3.07,4.16,;4.41,3.39,;5.74,4.16,;5.74,5.7,;7.08,3.39,;7.08,4.93,)|

CCNc1nc(Nc2cn(nc2[C@H]2C[C@H](C2)n2nccn2)C2CC2)ncc1C(F)(F)F |r,wD:12.12,14.17,(8.41,1.08,;7.08,1.85,;5.74,1.08,;4.41,1.85,;3.07,1.08,;1.74,1.85,;.41,1.08,;.41,-.46,;1.65,-1.36,;1.18,-2.83,;-.36,-2.83,;-.84,-1.36,;-2.33,-.96,;-3.1,.37,;-4.43,-.4,;-3.66,-1.73,;-5.92,-0,;-6.39,1.46,;-7.93,1.46,;-8.41,-0,;-7.16,-.91,;1.95,-4.16,;1.95,-5.7,;3.28,-4.93,;1.74,3.39,;3.07,4.16,;4.41,3.39,;5.74,4.16,;5.74,5.7,;7.08,3.39,;7.08,4.93,)|

CNc1nc(Nc2cn(nc2[C@H]2C[C@@H](C2)n2nccn2)C2CC2)ncc1C(F)(F)F |r,wU:11.11,wD:13.16,(7.74,1.85,;6.41,1.08,;5.08,1.85,;3.74,1.08,;2.41,1.85,;1.07,1.08,;1.07,-.46,;2.32,-1.36,;1.84,-2.83,;.3,-2.83,;-.17,-1.36,;-1.66,-.96,;-2.99,-1.73,;-3.76,-.4,;-2.43,.37,;-5.25,-0,;-5.73,1.46,;-7.27,1.46,;-7.74,-0,;-6.5,-.91,;2.61,-4.16,;2.61,-5.7,;3.95,-4.93,;2.41,3.39,;3.74,4.16,;5.08,3.39,;6.41,4.16,;6.41,5.7,;7.74,3.39,;7.74,4.93,)|

CNc1nc(Nc2cn(nc2[C@H]2C[C@H](C2)n2nccn2)C2CC2)ncc1C(F)(F)F |r,wD:11.11,13.16,(7.74,1.85,;6.41,1.08,;5.08,1.85,;3.74,1.08,;2.41,1.85,;1.07,1.08,;1.07,-.46,;2.32,-1.36,;1.84,-2.83,;.3,-2.83,;-.17,-1.36,;-1.66,-.96,;-2.43,.37,;-3.76,-.4,;-2.99,-1.73,;-5.25,-0,;-5.73,1.46,;-7.27,1.46,;-7.74,-0,;-6.5,-.91,;2.61,-4.16,;2.61,-5.7,;3.95,-4.93,;2.41,3.39,;3.74,4.16,;5.08,3.39,;6.41,4.16,;6.41,5.7,;7.74,3.39,;7.74,4.93,)|

CCNc1nc(Nc2cnn(C3CNCCC3(F)F)c2C)ncc1C(F)(F)F

CCN1CCC(F)(F)C(C1)n1ncc(Nc2ncc(c(NC)n2)C(F)(F)F)c1Cl

CCNc1nc(Nc2cnn(C3CN(CC)CCC3(F)F)c2Cl)ncc1C(F)(F)F

CCNc1nc(Nc2cn(nc2Cl)C2C[C@@H]2C#N)ncc1C(F)(F)F |r|

CCNc1nc(Nc2cn(nc2Cl)C2C[C@H]2C#N)ncc1C(F)(F)F |r|

CNc1nc(Nc2cn(nc2C2CC2)C2C[C@@H]2C#N)ncc1C(F)(F)F |r|

CNc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1C(F)(F)F |r|

FC(F)CNc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1C(F)(F)F |r|

COc1nc(Nc2cn(nc2C2CC2)C2C[C@@H]2C#N)ncc1Br |r|

COc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1Br |r|

CCNc1nc(Nc2cn(nc2C2CC2)C2C[C@@H]2C#N)ncc1Br |r|

CCNc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1Br |r|

CCNc1nc(Nc2cn(nc2C)C2(CF)CCOC2=O)ncc1C(F)(F)F

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CCN(C)CC1(F)F)N1CCOCC1

CNC(=O)[C@H]1CN(CCO1)c1cc(nc(OC)n1)-n1ncc2cc(C)c(cc12)C1CCN(C)CC1(F)F

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CCN(CC1(F)F)C1COC1)N1CCOCC1

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)[C@H]1CCN(C)C[C@H]1F)N1CC(O)C1

CN1CC[C@@H]([C@H](F)C1)c1cc2n(ncc2cc1C)-c1cc(nc(C)n1)N1CC(O)C1

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)[C@H]1CCNC[C@H]1F)N1CCOCC1

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CCNCC1(F)F)N1CC(C1)C#N

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CCN(CC1)C1COC1)N1CC(O)C1

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)N1CCOCC1)N1CCNCC1

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CCN(CC1F)C1COC1)N1CCO[C@@H](CO)C1

Cc1cc2cnn(-c3cc(nc(C)n3)N3CCO[C@H](CO)C3)c2cc1C1CCN(CC1)C1COC1

Cc1cc2cnn(-c3cc(nc(C)n3)N3CCO[C@@H](CO)C3)c2cc1C1CCNCC1

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CCNCC1)N1CCOCC1

Cc1nc(cc(n1)-n1ncc2cc(Cl)c(cc12)C1CCN(CC1)C1COC1)N1CCO[C@H](CO)C1

COc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CN(C)CCO1)N1CC(O)C1

Cc1nc(cc(n1)-n1ncc2cc(C)c(cc12)C1CCOCC1)N1CCO[C@@H](CO)C1

Cc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1

Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)c(Cl)n2c1 |r|

Cc1cccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)c(Cl)n2c1 |r|

Cc1c(NC(=O)[C@@H]2C[C@@H]2F)nc2ccc(cn12)-c1cnccc1C |r|

Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)c(Cl)n2c1 |r|

Cc1c(NC(=O)[C@@H]2C[C@@H]2F)nc2ccc(cn12)-c1cccc(F)c1C |r|

Cc1c(NC(=O)[C@@H]2C[C@@H]2F)nc2ccc(cn12)-c1c(C)cccc1F |r|

Cc1c(NC(=O)[C@@H]2C[C@@H]2F)nc2ccc(cn12)-c1cncc(F)c1C |r|

Cc1ccc(F)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccc(O)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

COC(=O)c1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccc2[nH]ccc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1

Cc1c(F)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)c(Cl)n2c1 |r|

Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1)C#N |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cc[nH]n1 |r|

Cc1c[nH]nc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(O)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cnccc1Cl |r|

Cc1cccc(c1C)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccc(N)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

CNc1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

CC(=O)Nc1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccc(Cl)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cnc2[nH]ccc2c1 |r|

Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1)-c1cc[nH]n1 |r|

Cc1cc(Cl)ccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(Cl)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cnccc1C(F)(F)F |r|

Cc1ccc(c(C)c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)c(F)n2c1 |r|

Cc1ccc(C)c(c1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1ccc2CC(=O)Nc2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cnccc1C#N |r|

Cc1c(F)ccc(c1C)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1cc(F)cc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1cc(F)ccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1)-c1cc[nH]c1 |r|

Cc1ccsc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1cccc(C)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1cc(F)c(O)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)c(F)ccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)ccc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)c(Cl)ccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccnc(F)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

COc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1cc(N)ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)cc(N)cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccc2NC(=O)Cc2c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1cccc(Cl)c1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c[nH]c2ncc(cc12)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1ccc2sc(=O)[nH]c2c1 |r|

Nc1ccc(cn1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1ccc(cc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1)-n1cccn1 |r|

OCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

COc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cccc(F)c1C#N |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cccc(F)c1F |r|

Cc1c[nH]c2ccc(C)c(-c3ccc4nc(NC(=O)[C@@H]5C[C@@H]5F)cn4c3)c12 |r|

COCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

F[C@H]1C[C@H]1C(=O)Nc1cn2cc(ccc2n1)-c1cccc(F)c1-c1ccco1 |r|

CSc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1cc(F)ncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

CC(=O)c1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

CN(C)c1cc(C)c(cn1)-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)cccc1-c1ccc2nc(NC(=O)C3CC3)cn2c1

Cc1c(F)cccc1-c1ccc2nc(NC(=O)[C@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@H]3F)cn2c1 |r|

Cc1c(F)cccc1-c1ccc2nc(NC(=O)[C@H]3C[C@H]3F)cn2c1 |r|

NCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

CC(=O)NCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

Cc1c(F)cccc1-c1ccc2nc(NC(=O)C3CCC3)cn2c1

Cc1c(F)cccc1-c1ccc2nc(NC(=O)C3CC3(F)F)cn2c1

Cc1c(F)cccc1-c1ccc2nc(NC(=O)C3CC(F)C3)cn2c1 |w:15.17,19.20,(4.93,-.52,;6.02,.57,;7.5,.17,;7.9,-1.32,;8.59,1.26,;8.19,2.74,;6.71,3.14,;5.62,2.05,;4.13,2.45,;3.73,3.94,;2.24,4.34,;1.08,3.23,;-.46,3.23,;-.94,1.76,;-2.43,1.36,;-3.51,2.45,;-3.12,3.94,;-5,2.05,;-6.34,2.82,;-7.11,1.49,;-8.59,1.09,;-5.77,.72,;.31,.86,;1.55,1.76,;3.04,1.36,)|

Cc1c(F)cccc1-c1ccc2nc(NC(=O)C3CC(F)(F)C3)cn2c1

CNCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

CC(C)NCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

COCCOCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

OCCOCc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

CN(C)Cc1c(F)cccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)cn2c1 |r|

C[C@@H]1C[C@@H](CCO1)Nc1c(NC(=O)C2CC[C@H](F)CC2)cnc2ccc(Cl)cc12 |r,wU:16.17,wD:3.7,1.0,(-2.53,5.15,;-2.53,3.61,;-1.2,2.84,;-1.2,1.3,;-2.53,.53,;-3.87,1.3,;-3.87,2.84,;.13,.53,;.13,-1.01,;1.47,-1.78,;2.8,-1.01,;4.14,-1.78,;4.14,-3.32,;5.47,-1.01,;6.8,-1.78,;8.14,-1.01,;8.14,.53,;9.47,1.3,;6.8,1.3,;5.47,.53,;1.47,-3.32,;.13,-4.09,;-1.2,-3.32,;-2.53,-4.09,;-3.87,-3.32,;-3.87,-1.78,;-5.2,-1.01,;-2.53,-1.01,;-1.2,-1.78,)|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1C[C@H](F)C1 |r,wU:23.27,wD:3.7,1.0,(8.18,-2.86,;7.71,-4.33,;8.74,-5.47,;8.26,-6.94,;6.76,-7.26,;5.73,-6.11,;6.2,-4.65,;9.29,-8.08,;10.83,-7.92,;11.45,-9.33,;10.31,-10.36,;10.31,-11.9,;8.97,-12.67,;7.64,-11.9,;6.31,-12.67,;4.97,-11.9,;4.97,-10.36,;3.64,-9.59,;6.31,-9.59,;7.64,-10.36,;8.97,-9.59,;11.6,-6.59,;13.08,-6.19,;12.68,-4.7,;13.45,-3.37,;11.2,-5.1,)|

C[C@@H]1C[C@@H](CCO1)Nc1c(NC(=O)C2C[C@@](C)(F)C2)cnc2ccc(Cl)cc12 |r,wU:15.17,wD:3.7,1.0,15.16,(.69,7.85,;.15,6.41,;1.13,5.22,;.59,3.77,;-.93,3.52,;-1.91,4.71,;-1.37,6.15,;1.57,2.58,;1.4,1.04,;2.74,.27,;3.82,1.36,;5.31,1.76,;6.4,.67,;5.71,3.25,;4.94,4.58,;6.27,5.35,;5.19,6.44,;7.61,6.12,;7.04,4.02,;2.74,-1.27,;1.4,-2.04,;.07,-1.27,;-1.27,-2.04,;-2.6,-1.27,;-2.6,.27,;-3.93,1.04,;-1.27,1.04,;.07,.27,)|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)[C@H]1CCOC1 |r|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1CC(C)(F)C1 |r|

CO[C@H]1CC(C1)c1nc2cnc3ccc(Cl)cc3c2n1C1CCO[C@H](C)C1 |r,wU:2.1,wD:24.28,(4.15,5.34,;4.92,4,;4.15,2.67,;4.54,1.16,;3.05,.76,;2.65,2.25,;2.28,-.57,;2.91,-1.98,;1.76,-3.01,;1.76,-4.55,;.43,-5.32,;-.91,-4.55,;-2.24,-5.32,;-3.57,-4.55,;-3.57,-3.01,;-4.91,-2.24,;-2.24,-2.24,;-.91,-3.01,;.43,-2.24,;.75,-.73,;-.28,.41,;-1.79,.09,;-2.82,1.24,;-2.34,2.7,;-.84,3.02,;-.36,4.49,;.19,1.88,)|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1CCOCC1 |r|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1CCC(F)(F)CC1 |r|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1CCCO1 |r|

CC1CC(CO1)c1nc2cnc3ccc(Cl)cc3c2n1[C@@H]1CCO[C@H](C)C1 |r|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1CCC(F)(F)C1 |r|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1COC1 |r|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)[C@H]1CC[C@@H](F)C1

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCC(F)C1 |r|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)[C@@H]1CC[C@H](F)CC1 |wU:25.29,22.25,3.7,1.0,(1.71,5.89,;3.19,5.46,;3.56,3.97,;5.04,3.54,;6.15,4.6,;5.78,6.1,;4.31,6.53,;5.41,2.04,;6.83,1.46,;6.72,-.08,;5.22,-.44,;4.5,-1.8,;2.96,-1.85,;2.14,-.54,;.61,-.59,;-.21,.72,;.52,2.08,;2.06,2.13,;2.87,.82,;4.41,.87,;-.29,3.39,;-1.1,4.7,;8.14,2.27,;9.5,1.54,;10.81,2.35,;10.76,3.89,;12.07,4.71,;9.4,4.62,;8.09,3.81,)|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)[C@H]1CCOC1

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCC(F)(F)CC1 |r|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1C[C@@](C)(F)C1 |r,wU:24.29,wD:24.28,1.0,(-.33,4.87,;-.72,3.38,;.36,2.29,;-.03,.81,;-1.52,.41,;-2.61,1.5,;-2.21,2.98,;1.06,-.28,;2.59,-.12,;3.21,-1.53,;2.07,-2.56,;2.07,-4.1,;.74,-4.87,;-.6,-4.1,;-1.93,-4.87,;-3.27,-4.1,;-3.27,-2.56,;-1.93,-1.79,;-.6,-2.56,;.74,-1.79,;-4.6,-1.79,;-5.93,-1.02,;3.36,1.21,;2.96,2.7,;4.45,3.1,;3.68,4.43,;5.93,3.5,;4.84,1.61,)|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1C[C@H](F)C1 |r,wU:24.28,wD:1.0,(.03,4.87,;-.37,3.38,;.72,2.29,;.33,.81,;-1.16,.41,;-2.25,1.5,;-1.85,2.98,;1.41,-.28,;2.95,-.12,;3.57,-1.53,;2.43,-2.56,;2.43,-4.1,;1.09,-4.87,;-.24,-4.1,;-1.57,-4.87,;-2.91,-4.1,;-2.91,-2.56,;-1.57,-1.79,;-.24,-2.56,;1.09,-1.79,;-4.24,-1.79,;-5.57,-1.02,;3.72,1.21,;5.2,1.61,;4.8,3.1,;5.57,4.43,;3.32,2.7,)|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCCCC1(F)F |r|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C(F)F)[C@H]1CCOC1 |r|

CN1CCC(C1)n1c(nc2cnc3ccc(cc3c12)C#N)C1C[C@@](C)(F)C1 |r,wU:23.28,wD:23.27,(-3.38,3.26,;-2.05,2.49,;-.8,3.39,;.44,2.49,;-.03,1.02,;-1.57,1.02,;1.06,-.06,;2.59,.1,;3.21,-1.31,;2.07,-2.34,;2.07,-3.88,;.74,-4.65,;-.6,-3.88,;-1.93,-4.65,;-3.27,-3.88,;-3.27,-2.34,;-1.93,-1.57,;-.6,-2.34,;.74,-1.57,;-4.6,-1.57,;-5.93,-.8,;3.36,1.43,;2.96,2.92,;4.45,3.32,;3.68,4.65,;5.93,3.72,;4.84,1.83,)|

CN1CCC(C1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CC[C@H](F)CC1 |r,wU:24.28,(-3.25,2.87,;-1.92,2.1,;-.67,3,;.58,2.1,;.1,.63,;-1.44,.63,;1.19,-.45,;2.72,-.29,;3.35,-1.7,;2.2,-2.73,;2.2,-4.27,;.87,-5.04,;-.47,-4.27,;-1.8,-5.04,;-3.13,-4.27,;-3.13,-2.73,;-1.8,-1.96,;-.47,-2.73,;.87,-1.96,;-4.47,-1.96,;-5.8,-1.19,;3.49,1.04,;5.03,1.04,;5.8,2.37,;5.03,3.71,;5.8,5.04,;3.49,3.71,;2.72,2.37,)|

CN1CCC(C1)n1c(nc2cnc3ccc(cc3c12)C#N)C1C[C@H](F)C1 |r,wU:23.27,(-2.84,3.18,;-1.51,2.41,;-.26,3.32,;.99,2.41,;.51,.95,;-1.03,.95,;1.6,-.14,;3.13,.02,;3.76,-1.39,;2.61,-2.42,;2.61,-3.96,;1.28,-4.73,;-.05,-3.96,;-1.39,-4.73,;-2.72,-3.96,;-2.72,-2.42,;-1.39,-1.65,;-.05,-2.42,;1.28,-1.65,;-4.06,-1.65,;-5.39,-.88,;3.9,1.35,;5.39,1.75,;4.99,3.24,;5.39,4.73,;3.5,2.84,)|

CN1CCC(C1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCOC1

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(cc3c12)C(F)(F)F)C1CCOC1 |r|

FC1(F)CC(C1)c1nc2cnc3ccc(Cl)cc3c2n1C1CCOC(CC#N)C1

F[C@H]1CCC(CC1)c1nc2cnc3ccc(Cl)cc3c2n1C1CCO[C@H](CC#N)C1 |r,wU:1.0,wD:25.29,(5.13,4.81,;4.36,3.48,;5.13,2.15,;4.36,.81,;2.82,.81,;2.05,2.15,;2.82,3.48,;2.05,-.52,;2.68,-1.93,;1.54,-2.96,;1.54,-4.5,;.2,-5.27,;-1.13,-4.5,;-2.47,-5.27,;-3.8,-4.5,;-3.8,-2.96,;-5.13,-2.19,;-2.47,-2.19,;-1.13,-2.96,;.2,-2.19,;.52,-.68,;-.57,.41,;-2.05,.01,;-3.14,1.1,;-2.75,2.58,;-1.26,2.98,;-.86,4.47,;-1.95,5.56,;-3.04,6.65,;-.17,1.89,)|

Clc1ccc2ncc3nc([C@H]4CCOC4)n(C4CCOC(CC#N)C4)c3c2c1 |r|

C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(F)cc3c12)C1C[C@@](C)(F)C1 |wU:23.28,wD:1.0,23.27,(1.71,-4.35,;3.19,-3.92,;3.56,-2.43,;5.04,-2,;6.15,-3.06,;5.78,-4.56,;4.31,-4.99,;5.41,-.5,;6.83,.08,;6.72,1.62,;5.22,1.98,;4.5,3.34,;2.96,3.39,;2.14,2.08,;.61,2.13,;-.21,.82,;.52,-.54,;-.29,-1.85,;2.06,-.59,;2.87,.72,;4.41,.67,;8.14,-.73,;9.64,-.38,;9.99,-1.88,;11.49,-1.53,;10.34,-3.38,;8.49,-2.23,)|

CN1CC[C@H](C1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCC(F)C1 |r|

CN1CC[C@H](C1)n1c(nc2cnc3ccc(F)cc3c12)C1CCC(F)C1 |r|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(F)cc3c12)C1CCC(F)C1 |r|

CC1(C)CC(CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCC(F)C1

F[C@H]1C[C@@H](C1)c1nc2cnc3ccc(cc3c2n1C1CCOCC1(F)F)C#N |r,wU:1.0,wD:3.5,(5.71,5.55,;4.94,4.22,;5.34,2.73,;3.85,2.33,;3.45,3.82,;3.08,1,;3.44,-.41,;2.29,-1.44,;2.29,-2.98,;.96,-3.75,;-.37,-2.98,;-1.71,-3.75,;-3.04,-2.98,;-3.04,-1.44,;-1.71,-.67,;-.37,-1.44,;.96,-.67,;.93,.96,;-.16,2.05,;-1.65,1.65,;-2.74,2.74,;-2.34,4.22,;-.85,4.62,;.24,3.53,;1.73,3.14,;1.33,4.62,;-4.37,-.67,;-5.71,.1,)|

CO[C@H]1C[C@@H](C1)c1nc2cnc3ccc(cc3c2n1C1CCOCC1(F)F)C#N |r,wU:2.1,wD:4.6,(6.45,5.15,;4.96,5.55,;4.19,4.22,;4.59,2.73,;3.1,2.33,;2.71,3.82,;2.33,1,;2.7,-.41,;1.55,-1.44,;1.55,-2.98,;.22,-3.75,;-1.12,-2.98,;-2.45,-3.75,;-3.78,-2.98,;-3.78,-1.44,;-2.45,-.67,;-1.12,-1.44,;.22,-.67,;.19,.96,;-1.15,1.73,;-2.48,.96,;-3.82,1.73,;-3.82,3.27,;-2.48,4.04,;-1.15,3.27,;.39,3.27,;-.38,4.6,;-5.12,-.67,;-6.45,.1,)|

CN1CC(n2c(nc3cnc4ccc(cc4c23)C#N)C2CCC(F)C2)C(F)(F)C1

CCc1nc2cnc3ccc(Cl)cc3c2n1[C@@H]1CCO[C@H](CC#N)C1 |r|

CCc1nc2cnc3ccc(Cl)cc3c2n1[C@H]1CCO[C@@H](CC#N)C1 |r|

CN1C[C@H](n2c(Cn3ncc(C)n3)nc3cnc4ccc(cc4c23)C#N)C(F)(F)C1 |r|

CN1C[C@@H](n2c(Cn3ncc(C)n3)nc3cnc4ccc(cc4c23)C#N)C(F)(F)C1 |r|

Cc1cc(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@H]2CCOCC2(F)F)no1 |r|

CN1CC[C@H](C1)n1c(Cc2cc(C)ncn2)nc2cnc3ccc(cc3c12)C#N |r|

Cc1cnc(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@H]2CCOCC2(F)F)cn1 |r|

Cc1cnc(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@@H]2CCOCC2(F)F)cn1 |r|

C[C@@H]1CC(CCO1)n1c(Cc2cn(C)nn2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

Clc1ccc2ncc3nc(C4CCC4)n(C4CCO[C@@H](CC#N)C4)c3c2c1 |r|

Clc1ccc2ncc3nc(C4CCC4)n(C4CCO[C@H](CC#N)C4)c3c2c1 |r|

COc1cnn(Cc2nc3cnc4ccc(cc4c3n2[C@@H]2CCO[C@H](C)C2)C(F)F)c1 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cnc(C)cn2)nc2cnc3ccc(cc3c12)C(F)F |r|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C(O)c1cnc(C)cn1 |r|

C[C@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C(O)c1cnc(C)cn1 |r|

CN1C[C@H](n2c(Cn3cncn3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1 |r|

CN1C[C@@H](n2c(Cn3cncn3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1 |r|

CN1C[C@H](n2c(Cn3cc(C)nn3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1 |r|

CN1C[C@@H](n2c(Cn3cc(C)nn3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1 |r|

CN1C[C@H](n2c(Cc3cnc(C)cn3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1 |r|

CN1C[C@@H](n2c(Cc3cnc(C)cn3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1 |r|

COCc1cn(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@H]2CN(C)CC2(F)F)nn1 |r|

COCc1cn(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@@H]2CN(C)CC2(F)F)nn1 |r|

CN1C[C@H](n2c(Cn3cncn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1 |r|

CN1C[C@@H](n2c(Cn3cncn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1 |r|

COc1cnn(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@H]2CCOCC2(F)F)c1 |r|

COc1cnn(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@@H]2CCOCC2(F)F)c1 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cn3nc(C)sc3n2)nc2cnc3ccc(F)cc3c12 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cnc(C)cn2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)C1CCCC1 |r|

Cc1nc2cnc3ccc(Cl)cc3c2n1C1CCOC(CC#N)C1

CN1CC(n2c(Cc3noc(C)n3)nc3cnc4ccc(cc4c23)C#N)C(F)(F)C1

CN1CC[C@H](C1)n1c(Cc2cnc(C)cn2)nc2cnc3ccc(cc3c12)C#N |r|

CN1CC[C@H](C1)n1c(Cn2nnc(C)n2)nc2cnc3ccc(cc3c12)C#N |r|

CN1CC[C@H](C1)n1c(Cc2cc(C)no2)nc2cnc3ccc(cc3c12)C#N |r|

COc1cnn(Cc2nc3cnc4ccc(cc4c3n2[C@@H]2CCN(C)C2)C#N)c1 |r|

CN1CC[C@H](C1)n1c(Cc2nnc(C)s2)nc2cnc3ccc(cc3c12)C#N |r|

CN1CC[C@H](C1)n1c(Cc2ncc(C)o2)nc2cnc3ccc(cc3c12)C#N |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cnc(cn2)C(F)(F)F)nc2cnc3ccc(cc3c12)C#N |r|

CN1CC[C@H](C1)n1c(Cc2cc(C)ncn2)nc2cnc3ccc(Cl)cc3c12 |r|

COc1cnn(Cc2nc3cnc4ccc(cc4c3n2[C@@H]2CCO[C@H](C)C2)C(F)(F)F)c1 |r|

CN1CC[C@H](C1)n1c(Cc2noc(C)n2)nc2cnc3ccc(Cl)cc3c12 |r|

CN1CC(n2c(Cn3cncn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

COCc1cn(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CN(C)CC2(F)F)nn1

CN1CC(n2c(Cc3noc(C)n3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

Cc1cn(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CCOCC2(F)F)nn1

CN1CC(n2c(Cn3cc(nn3)C3CC3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

CN1CC(n2c(Cn3cc(C)nn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

CN1CC(n2c(Cn3nnc(C)n3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

CN1CC(n2c(Cc3cnc(C)cn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

CN1CC(n2c(Cc3cc(C)on3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

COCc1cn(Cc2nc3cnc4ccc(F)cc4c3n2C2CN(C)CC2(F)F)nn1

FC1(F)COCCC1n1c(Cn2cncn2)nc2cnc3ccc(Cl)cc3c12

COCc1cn(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CCOCC2(F)F)nn1

Cc1nc(Cc2nc3cnc4ccc(cc4c3n2[C@@H]2CCN(CC(F)(F)F)C2)C#N)no1 |r|

COc1cnn(Cc2nc3cnc4ccc(cc4c3n2[C@@H]2CCO[C@H](C)C2)C#N)c1 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2nccs2)nc2cnc3ccc(Cl)cc3c12 |r|

Cc1cc(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CCOC(C2)C(F)F)no1

Cc1cc(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CCOCC2(F)F)no1

C[C@@H]1C[C@@H](CCO1)n1c(Cc2nccs2)nc2cnc3ccc(cc3c12)C#N |r|

CN1CC[C@H](C1)n1c(Cn2cc(C)nn2)nc2cnc3ccc(Cl)cc3c12 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2csnn2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2nccs2)nc2cnc3ccc(F)cc3c12 |r|

F[C@H]1CC[C@H](C1)n1c(Cc2nc3ccccc3o2)nc2cnc3ccc(cc3c12)C#N |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cn2cncn2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

CN1CC[C@H](C1)n1c(Cc2cnc(C)cn2)nc2cnc3ccc(Cl)cc3c12 |r|

Cc1cc(Cc2nc3cnc4ccc(cc4c3n2[C@@H]2CC[C@H](F)C2)C#N)no1 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cscn2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2nnc(C)o2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

CC1(C)CC(CCO1)n1c(Cn2cncn2)nc2cnc3ccc(Cl)cc3c12

COc1cnn(Cc2nc3cnc4ccc(Cl)cc4c3n2CC(C)(F)F)c1

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cnc(cn2)C(F)(F)F)nc2cnc3ccc(F)cc3c12 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2nnc(C)s2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

Cc1nc(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CCOCC2(F)F)no1

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cc(C)ncn2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

Cc1cnc(Cc2nc3cnc4ccc(Cl)cc4c3n2[C@@H]2CC[C@H](F)C2)cn1 |r|

CC(Cc1nc2cnc3ccc(Cl)cc3c2n1[C@@H]1CCO[C@H](C)C1)C#N |r|

FC1CCC(C1)n1c(Cc2csnn2)nc2cnc3ccc(F)cc3c12

C[C@@H]1C[C@@H](CCO1)n1c(CCC#N)nc2cnc3ccc(Cl)cc3c12 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cn2nnc(C)n2)nc2cnc3ccc(cc3c12)C(F)(F)F |r|

CN1CC(n2c(Cn3cnnn3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

CN1CC(n2c(Cc3ncn(C)n3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

CN1CC(n2c(Cc3cn4nc(C)sc4n3)nc3cnc4ccc(F)cc4c23)C(F)(F)C1

CN1CC(n2c(Cn3ncc(C)n3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

CN1CC(n2c(Cc3nnc(C)s3)nc3cnc4ccc(Cl)cc4c23)C(F)(F)C1

C[C@@H]1C[C@@H](CCO1)n1c(Cn2cc(C)nn2)nc2cnc3ccc(cc3c12)C(F)F |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cc(C)on2)nc2cnc3ccc(cc3c12)C(F)F |r|

Cc1nnc(Cc2nc3cnc4ccc(Cl)cc4c3n2C2CCOCC2(F)F)s1

FC1(F)COCCC1n1c(Cn2cc(nn2)C2CC2)nc2cnc3ccc(Cl)cc3c12

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cnc(CO)cn2)nc2cnc3ccc(F)cc3c12 |r|

C[C@@H]1C[C@@H](CCO1)n1c(Cc2cnc(C)cn2)nc2cnc3ccc(Cl)cc3c12 |r|

C[n]1C=C(c2cnc(Nc3cnn(C)c3Cl)nc12)C(F)(F)F |c:2|

COc1nn(cc1Nc1ncc2c(Cl)cn(C)c2n1)C(C)C

CC(C)n1cc(Nc2ncc3c(Cl)cn(C)c3n2)c(Cl)n1

Cn1cc(Cl)c2cnc(Nc3cn(nc3C(F)(F)F)C3CCOCC3)nc12

Cn1ncc(Nc2ncc3c(Cl)cn(C)c3n2)c1Cl

CCn1cc(Cl)c2cnc(Nc3cnn(C)c3Cl)nc12

CC(C)n1cc(Nc2ncc3c(Cl)cn(C(C)C)c3n2)c(Cl)n1

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C(C)C)nc12

CC(C)n1cc(Nc2ncc3c(Cl)cn(C)c3n2)c(n1)C(F)(F)F

COCCn1cc(Nc2ncc3c(Cl)cn(C)c3n2)c(n1)C(F)(F)F

CCCCn1cc(Nc2ncc3c(Cl)cn(C)c3n2)c(n1)C(F)(F)F

CCn1cc(Cl)c2cnc(Nc3cn(CCOC)nc3Cl)nc12

CCn1cc(Cl)c2cnc(Nc3cn(CC4CC4)nc3Cl)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CC3)nc12

Clc1nn(cc1Nc1ncc2c(Cl)cn(C3CC3)c2n1)C1CC1

CCn1cc(Cl)c2cnc(Nc3cnn(C4COC4)c3Cl)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(C)CC3)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCOCC3)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CC(C)OC(C)C3)nc12

CCN1CCC(CC1)n1cc(Nc2ncc3c(Cl)cn(CC)c3n2)c(Cl)n1

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)-c3ccc(F)cc3)nc12

CCn1cc(Cl)c2cnc(Nc3cnn(c3Cl)-c3ccc(Cl)cc3)nc12

CC(=O)N1CCC(CC1)n1ncc(Nc2ncc3c(Cl)cn(C)c3n2)c1Cl

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)C3CC3)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)S(C)(=O)=O)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)C(C)C)nc12

Cn1cc(Cl)c2cnc(Nc3cnn(C4CCN(CC4)C4COC4)c3Cl)nc12

CCn1cc(Cl)c2cnc(Nc3cnn(C4CCN(CC4)C4COC4)c3Cl)nc12

Clc1cn(C2CC2)c2nc(Nc3cnn(C4CCN(CC4)C4COC4)c3Cl)ncc12

CS(=O)(=O)N1CCC(CC1)n1cc(Nc2ncc3c(Cl)cn(C4CC4)c3n2)c(Cl)n1

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)N3CCOCC3)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)N3CCN(C)CC3)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)C(C)(C)C)nc12

CCn1cc(Cl)c2cnc(Nc3c(C)nn(C4CCN(CC4)S(C)(=O)=O)c3C)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)S(=O)(=O)C3CC3)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)[C@@H]3CCN(C3)S(C)(=O)=O)nc12 |r|

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)[C@H]3CCN(C3)S(C)(=O)=O)nc12 |r|

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)[C@@H]3CCN(C3)C(=O)C3CCCC3)nc12 |r|

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)[C@H]3CCN(C3)C(=O)C3CCCC3)nc12 |r|

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CN(C3)S(C)(=O)=O)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CN(C3)C(=O)C3CC3)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCCN(CC3)S(C)(=O)=O)nc12

CCn1cc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCCN(CC3)C(=O)C3CC3)nc12

CCn1nc(Cl)c2cnc(Nc3cnn(C4CCN(CC4)C4COC4)c3Cl)nc12

CS(=O)(=O)N1CCC(CC1)n1cc(Nc2ncc3c(Cl)nn(C4CC4)c3n2)c(Cl)n1

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)S(=O)(=O)C3CC3)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)C(F)(F)F)nc12

CS(=O)(=O)N1CCC(CC1)n1cc(Nc2ncc3c(Cl)nn(CC(F)(F)F)c3n2)c(Cl)n1

FC(F)(F)Cn1nc(Cl)c2cnc(Nc3cnn(C4CCN(CC4)C4COC4)c3Cl)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCCN(CC3)S(C)(=O)=O)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCCN(CC3)C(=O)C3CC3)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)C(C)(C)C)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)N3CCOCC3)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)S(C)(=O)=O)nc12

CCn1nc(Cl)c2cnc(Nc3c(Cl)nn(C4CCN(CC4)C(=O)C4CC4)c3C)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(=O)C3CC3)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)C(C)=O)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CCN(CC3)S(=O)(=O)CC)nc12

CCn1nc(Cl)c2cnc(Nc3cn(nc3Cl)C3CN(C3)C(=O)C3CC3)nc12

CCn1nc(Cl)c2cnc(Nc3cnn(C4CN(C4)C4COC4)c3Cl)nc12

CCn1nc(Cl)c2cnc(Nc3cnn(C4CCN(CC4)S(C)(=O)=O)c3Cl)nc12

CN1CCN(CC1)C2CCN(CC2)C(=O)c3ccc(c(c3)OC)Nc4ncc5c(n4)N(c6ccccc6C(=O)N5C)C

Fc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Brc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Fc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Ic1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Clc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

FC(F)(F)c1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Fc1cc(cc(F)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1nc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ccc(nc1)C#N

Cc1cc(cc(C)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ccc(cc1)C#N

Cc1n[nH]c2ccc(NC(=O)c3ccc(cc3C)C#N)cc12

Cc1nc(ccc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

COc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ccc(cn1)C#N

Cc1ccc(cc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1cnc(s1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)c1cccc(c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)c1ccnc(c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)c1cc(ccn1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)c1cncc(c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)c1cnc(nc1)C#N

Cc1c(cc(C#N)n1C)C(=O)Nc1ccc2[nH]nc(-c3ccccc3)c2c1

Cc1oc(cc1C(=O)Nc1ccc2[nH]nc(-c3ccccc3)c2c1)C#N

Cc1ccc(cc1C)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccco3)c2c1)C#N

CN(C)c1cccc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C3CCOCC3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)S(C)(=O)=O)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(cc3)C(F)(F)F)c2c1)C#N

Cc1oncc1-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cncc(c3)N3CCOCC3)c2c1)C#N

CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Oc1cc(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccccc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)C#N)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cncc(c3)C#N)c2c1)C#N

Cc1nc(C#N)n(C)c1C(=O)Nc1ccc2[nH]nc(-c3ccccc3)c2c1

Cc1cc(C#N)c(C)nc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

COc1cc(F)cc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

COc1ccc(cc1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

COc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(ncc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cccnc3)c2c1)C#N

Cc1cc(ccc1F)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

COc1ccc(cn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

COc1cccc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cccc(OC(F)(F)F)c3)c2c1)C#N

Cc1ccc(cn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1ccc(cc1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnn(C)c3)c2c1)C#N

Cc1cccc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)C(F)(F)F)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(nc3)C(F)(F)F)c2c1)C#N

Cc1cc(F)cc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)C3CC3)c2c1)C#N

Cc1ccc(cc1F)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

FC(F)c1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ncc(s1)C#N

Clc1cc(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

COc1cncc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

COc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(cc3)N3CCOCC3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc4ocnc4c3)c2c1)C#N

COc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccsc3)c2c1)C#N

Cc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

CCc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3coc(c3)C#N)c2c1)C#N

Fc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cc(n1)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Fc1c(ccnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1cc(C)c2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1nn(C)c(C#N)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1cc(on1)C#N

CCc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

C=Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(nc(C)c1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Clc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(I)c2c1)C#N

Cc1cc(NC(=O)c2cccc(C#N)c2C)cc2c(n[nH]c12)-c1ccoc1

Brc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1c(C(=O)Nc2ccc3[nH]nc(-c4ccoc4)c3c2)c(nn1C)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1cc(sn1)C#N

Cc1c(nn(C)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1c(nn(C)c1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1cc(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Clc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cn1c(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cn1nc(cc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1ccccc1-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

COc1ccccc1-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2n1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccno3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(CN4CCOCC4)s3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccnc(Br)c3)c2c1)C#N

Cc1c(nc(C#N)n1C)C(=O)Nc1ccc2[nH]nc(-c3ccccc3)c2c1

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(Br)c2c1)C#N

Oc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(cc3)C(=O)N3CCOCC3)c2c1)C#N

CC(C)Oc1cncc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cncs3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1cccc(n1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)C#N)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccccn3)c2c1)C#N

C[C@H]1CN(C[C@H](C)O1)c1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12 |r|

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ncc(C#N)c2ccsc12

C[C@H]1C[C@@H](C)CN(C1)c1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12 |r|

C[C@H]1CN(C[C@@H](C)O1)c1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12 |r|

C[C@H]1CN(C[C@@H](C)O1)c1cccc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12 |r|

Fc1ccc(C#N)c(F)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cncc(Cl)c3)c2c1)C#N

Fc1ccc(cc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1c(cnn1C)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cn1cc(nc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Oc1ccc(cc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-n3ccnc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1cccc(n1)C#N

Cc1ccc(C#N)c(F)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1ncc(o1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cc(cs3)C#N)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(s3)C#N)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1nccc(n1)C#N

Cc1c(n[nH]c1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1c(ccc(F)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-n3cccn3)c2c1)C#N

Cc1n[nH]c(C#N)c1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Brc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(Cl)s3)c2c1)C#N

Cc1ncc(s1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ccc(C#N)c2cccnc12

Cc1cc(cnc1C(=O)Nc1cc(F)c2[nH]nc(-c3ccoc3)c2c1)C#N

Clc1c(ccnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1nc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1)C#N

Cc1ncc(nc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1ccc(nc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

CCc1c(ccnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ncc(cc1C#C)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccc(=O)n(C)c3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccn(C)c(=O)c3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccn(C)n3)c2c1)C#N

Oc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1cc2c(n[nH]c2cn1)-c1ccoc1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cscn3)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

COc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnsc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ncc2[nH]nc(-c3ccoc3)c2n1)C#N

Cc1cc(nnc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

FC(F)n1cc(cn1)-c1n[nH]c2ccc(NC(=O)c3c(F)ccc(C#N)c3F)cc12

COc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1)C#N

Cc1cc(cc(F)c1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1)C#N

FC(F)n1cc(cn1)-c1n[nH]c2ccc(NC(=O)c3cccc(C#N)c3Cl)cc12

FC(F)n1cc(cn1)-c1n[nH]c2ccc(NC(=O)c3cccc(C#N)c3F)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)(F)F)c2c1

COc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ccnc(C#N)c3F)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cncc(Cl)c3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnn(CF)c3)c2c1

FC(F)(F)c1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

Cc1ncc(o1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1

COc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1ccc(C#N)c(F)c1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1

COc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C(F)(F)F)C#N)cc12

Cc1c(noc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1

Cc1c(noc1C(=O)Nc1ccc2[nH]nc(-c3ccoc3)c2c1)C#N

CC(C)c1ncc(o1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1cccc(n1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cn[nH]c3)c2c1

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

Cc1nc(C(=O)Nc2ccc3[nH]nc(-c4cnn(c4)C(F)F)c3c2)c(C)c(C)c1C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccn(C)c3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnn(C)c3)c2c1

Fc1ccc(C#N)c(F)c1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

COc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1)C#N

Cc1cc(cc(F)c1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1cc(cc(C)n1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

FC(F)n1cc(cn1)-c1n[nH]c2ccc(NC(=O)c3cccc(C#N)c3C(F)(F)F)cc12

Cc1ccc(C#N)c(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1

COc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3c(C)c(nn3C)C#N)cc12

Cc1c(nn(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1)C#N

Cc1c(nn(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1)C#N

Cc1coc(n1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ncco3)c2c1

Fc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

COc1cc(ccc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

COc1cc(cc(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C(F)F)c2c1)C#N

Cc1nc(C(=O)Nc2ccc3[nH]nc(-c4cnco4)c3c2)c(C)c(C)c1C#N

Cc1ccc(C#N)c(F)c1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccn(n3)C(F)F)c2c1

CCOc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

O=C(Nc1ccc2[nH]nc(-c3cnco3)c2c1)c1ncc(C#N)c2CCCc12

COc1cc(cc(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Clc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1nc(C(=O)Nc2ccc3[nH]nc(-c4cnoc4)c3c2)c(C)c(C)c1C#N

COc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

FC(F)(F)Oc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1c(cc(C#N)c(=O)n1C)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

CC(=C)c1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

CN1CCC(CC1)n1cc(cn1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1

CC(C)n1cc(cn1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

O=C(Nc1ccc2[nH]nc(-c3cnoc3)c2c1)c1ncc(C#N)c2CCCc12

COc1cc(cc(C)n1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Clc1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C3COC3)c2c1

Cc1nc(C(=O)Nc2ccc3[nH]nc(-c4cncs4)c3c2)c(C)c(C)c1C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1

Cn1cc(cc(C#N)c1=O)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

CC(C)c1c(cccc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

COc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cncs3)c2c1

COc1c(ccnc1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1)C#N

Cc1cc(on1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccncn3)c2c1

CCc1c(ccc(F)c1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

CCc1c(ccnc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(\C=C\C3CC3)c2c1

COc1c(ccc(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1cc(on1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

Cc1ccc(C#N)c(F)c1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1

Cc1nccc(n1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1cc2c(n[nH]c2cn1)-c1cnco1

Cc1c(nn(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cn(C)nn3)c2c1

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cn(C)nn3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-n3ccoc3=O)c2c1)C#N

CC(C)=Cc1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12 |(-7.69,-2.96,;-7.21,-1.49,;-8.24,-.35,;-5.7,-1.17,;-5.23,.29,;-6.13,1.54,;-5.23,2.79,;-3.76,2.31,;-2.43,3.08,;-1.1,2.31,;-1.1,.77,;.24,,;1.57,.77,;1.57,2.31,;2.91,,;2.91,-1.54,;4.24,-2.31,;5.57,-1.54,;6.91,-2.31,;8.24,-3.08,;5.57,,;6.91,.77,;4.24,.77,;4.24,2.31,;-2.43,,;-3.76,.77,)|

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(\C=C\c3ccccc3)c2c1

C\C=C\c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(cn(C)c1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1)C#N

Cn1cc(cc1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(\C=C\c3ccccn3)c2c1

COc1cc(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

CC(=C)c1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

CC(C)c1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C3CC3c3ccccc3)c2c1

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(N3CCC3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(N3CC(F)(F)C3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(OCc3ccccc3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(C3COC3)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C3CC3(C)C)c2c1

COc1cc(nc(C)c1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C=C3CCN(CC3)C(=O)OC(C)(C)C)c2c1 |(10.67,1.19,;9.34,.42,;8.01,1.19,;8.01,2.73,;6.67,.42,;6.67,-1.12,;8.01,-1.89,;9.34,-1.12,;10.67,-1.89,;12.01,-2.66,;5.34,1.19,;5.34,2.73,;4,.42,;2.67,1.19,;2.67,2.73,;1.34,3.5,;0,2.73,;-1.46,3.2,;-2.37,1.96,;-1.46,.71,;-1.94,-.75,;-3.44,-1.07,;-4.47,.07,;-5.98,-.25,;-6.46,-1.71,;-5.43,-2.86,;-3.92,-2.54,;-7.96,-2.03,;-8.44,-3.5,;-8.99,-.89,;-10.5,-1.21,;-10.98,-2.67,;-11.53,-.06,;-12.01,-1.53,;0,1.19,;1.34,.42,)|

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C=C3CCNCC3)c2c1 |(7.9,.87,;6.56,.1,;5.23,.87,;5.23,2.41,;3.9,.1,;3.9,-1.44,;5.23,-2.21,;6.56,-1.44,;7.9,-2.21,;9.23,-2.98,;2.56,.87,;2.56,2.41,;1.23,.1,;-.1,.87,;-.1,2.41,;-1.44,3.18,;-2.77,2.41,;-4.24,2.88,;-5.14,1.64,;-4.24,.39,;-4.71,-1.07,;-6.22,-1.39,;-7.25,-.25,;-8.76,-.57,;-9.23,-2.03,;-8.2,-3.18,;-6.69,-2.86,;-2.77,.87,;-1.44,.1,)|

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(\C=C3\CCOC3)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C=C3CCOCC3)c2c1 |(7.9,.87,;6.56,.1,;5.23,.87,;5.23,2.41,;3.9,.1,;3.9,-1.44,;5.23,-2.21,;6.56,-1.44,;7.9,-2.21,;9.23,-2.98,;2.56,.87,;2.56,2.41,;1.23,.1,;-.1,.87,;-.1,2.41,;-1.44,3.18,;-2.77,2.41,;-4.24,2.88,;-5.14,1.64,;-4.24,.39,;-4.71,-1.07,;-6.22,-1.39,;-7.25,-.25,;-8.76,-.57,;-9.23,-2.03,;-8.2,-3.18,;-6.69,-2.86,;-2.77,.87,;-1.44,.1,)|

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C=C3COC3)c2c1 |(7.46,.77,;6.12,,;4.79,.77,;4.79,2.31,;3.46,,;3.46,-1.54,;4.79,-2.31,;6.12,-1.54,;7.46,-2.31,;8.79,-3.08,;2.12,.77,;2.12,2.31,;.79,,;-.55,.77,;-.55,2.31,;-1.88,3.08,;-3.21,2.31,;-4.68,2.79,;-5.58,1.54,;-4.68,.29,;-5.15,-1.17,;-6.66,-1.49,;-7.95,-.65,;-8.79,-1.94,;-7.5,-2.78,;-3.21,.77,;-1.88,,)|

COCc1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C3CC3C(F)(F)F)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(\C=C/C(F)(F)F)c2c1

CC(=C)c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(c2c1)C1(C)CC1

COC(C)c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

CC(C)c1n[nH]c2ccc(NC(=O)c3nc(Cl)c(C#N)c(C)c3C)cc12

CCc1n[nH]c2ccc(NC(=O)c3nc(Cl)c(C#N)c(C)c3C)cc12

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3ccnnc3)c2c1)C#N

Cc1cc(cnn1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C)C#N)cc12

CC(=C)c1c(cccc1C(=O)Nc1ccc2[nH]nc(C)c2c1)C#N

Cc1n[nH]c2ccc(NC(=O)c3nc(C)c(C#N)c(C)c3Cl)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C=C3CCC3)c2c1 |(7.46,.77,;6.12,,;4.79,.77,;4.79,2.31,;3.46,,;3.46,-1.54,;4.79,-2.31,;6.12,-1.54,;7.46,-2.31,;8.79,-3.08,;2.12,.77,;2.12,2.31,;.79,,;-.55,.77,;-.55,2.31,;-1.88,3.08,;-3.21,2.31,;-4.68,2.79,;-5.58,1.54,;-4.68,.29,;-5.15,-1.17,;-6.66,-1.49,;-7.95,-.65,;-8.79,-1.94,;-7.5,-2.78,;-3.21,.77,;-1.88,,)|

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c2c1

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(-c3ccnc(c3)N3CCOCC3)c2c1

CCc1cc(ccn1)-c1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cccn(C)c3=O)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(\C=C\c3ccncc3)c2c1

C\C=C\c1n[nH]c2ccc(NC(=O)c3nc(Cl)c(C#N)c(C)c3C)cc12

Cc1nc(C(=O)Nc2ccc3[nH]nc(C4CC4)c3c2)c(Cl)c(C)c1C#N

CCc1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(c3C)C(F)(F)F)cc12

COc1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(c3C)C(F)(F)F)cc12

Cc1c(ncc(C#N)c1C(F)(F)F)C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1

COc1n[nH]c2ccc(NC(=O)c3nc(C)c(C#N)c(C)c3C)cc12

Cc1cc(C#N)c(nc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C(F)(F)F

Cc1c(ncc(C#N)c1C(F)(F)F)C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(C#N)c2c1

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(C(F)F)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(C(F)F)c2c1

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(c2c1)C(F)(F)F

CC(C)c1cc(cnc1C(=O)Nc1ccc2[nH]nc(C)c2c1)C#N

CC(C)c1c(cccc1C(=O)Nc1ccc2[nH]nc(C)c2c1)C#N

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(c2c1)S(C)(=O)=O

Cc1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3C)cc12

Cc1n[nH]c2ccc(NC(=O)c3nc(Cl)c(C#N)c(C)c3C)cc12

COc1c(ccc(C)c1C(=O)Nc1ccc2[nH]nc(C)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(Br)c2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(Cl)c2c1

Cc1n[nH]c2ccc(NC(=O)c3nc(Br)c(C#N)c(C)c3C)cc12

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1

COc1nc(C(=O)Nc2ccc(N)c(c2)C(=N)C2CC2)c(C)c(C)c1C#N

Cc1nc(C(=O)Nc2ccc(N)c(c2)C(=N)C2CC2)c(C)c(C)c1C#N

CC(=N)c1cc(NC(=O)c2ncc(C#N)c(Cl)c2C)ccc1N

CC(=N)c1cc(NC(=O)c2nc(Cl)c(cc2C)C#N)ccc1N

COc1n[nH]c2ccc(NC(=O)c3nc(Cl)c(C#N)c(C)c3C)cc12

Clc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnoc3)c2c1)C#N

O=C(Nc1ccc2[nH]nc(-c3cnoc3)c2c1)c1ncc(cc1C1CC1)C#N

COc1cccc(c1)-c1n[nH]c2ccc(NC(=O)c3ncc(cc3C3CC3)C#N)cc12

O=C(Nc1ccc2[nH]nc(-c3cnco3)c2c1)c1ncc(cc1C1CC1)C#N

CC(=C)c1cc(cnc1C(=O)Nc1ccc2[nH]nc(C)c2c1)C#N

Cc1c(C)c(ncc1C#N)C(=O)Nc1cc(F)c2[nH]ncc2c1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(F)c2c1

Cc1n[nH]c2ccc(NC(=O)c3c(F)ccc(C#N)c3C)cc12

CSc1n[nH]c2ccc(NC(=O)c3nc(Cl)c(C#N)c(C)c3C)cc12

Clc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cnco3)c2c1)C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)P(C)(C)=O)c2c1)C#N

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(Cl)c2c1

COc1nc(C(=O)Nc2ccc3[nH]nc(Cl)c3c2)c(C)c(C)c1C#N

COc1nc(C(=O)Nc2ccc3[nH]nc(C)c3c2)c(C)c(C)c1C#N

Cc1cc(cnc1C(=O)Nc1ccc2[nH]nc(CCCN3CCCCC3)c2c1)C#N

Cc1c(C)c(C#N)c(Cl)nc1C(=O)Nc1ccc2[nH]nc(Br)c2c1

Cc1n[nH]c2ccc(NC(=O)c3nc(C)c(C#N)c(C)c3C)cc12

Cc1n[nH]c2ccc(NC(=O)c3ncc(C#N)c(C)c3Cl)cc12

Cc1c(C)c(C#N)c(nc1C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1)C(F)F

Cc1c(C)c(C#N)c(nc1C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1)C(F)(F)F

COc1n[nH]c2ccc(NC(=O)c3nc(Br)c(C#N)c(C)c3C)cc12

Cc1c(C)c(C#N)c(Br)nc1C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1

Cc1c(Cl)c(nc(Cl)c1C#N)C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1

Cc1c(C)c(C#N)c(C=C)nc1C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1

CCc1nc(C(=O)Nc2ccc3[nH]nc(C4CC4)c3c2)c(C)c(C)c1C#N

Cc1c(C)c(C#N)c(nc1C(=O)Nc1ccc2[nH]nc(C3CC3)c2c1)C1CC1

Cc1c(C)c(ncc1C#N)C(=O)Nc1ccc2[nH]nc(-c3cnn(c3)C3CC3)c2c1

C[C@H]1COC[C@@H]1n1c(cc2cnc(Nc3cn(C)nc3OC3CN(C3)C(C)=O)nc12)C#N |r|

C[C@H]1COCC1Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

C[C@@H]1COCC1Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

C[C@H](C(F)F)n1cc(Nc2ncc3cc(C#N)n([C@H]4COC[C@@H]4C)c3n2)c(OC2COC2)n1 |r|

C[C@@H](C(F)F)n1cc(Nc2ncc3cc(C#N)n([C@H]4COC[C@@H]4C)c3n2)c(OC2COC2)n1 |r|

C[C@H]1OCC1Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

C[C@@H]1OCC1Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

C[C@H]1COC[C@@H]1n1c(cc2cnc(Nc3cn(C)nc3OC3COC3)nc12)C#N |r|

CC(CO)n1cc(Nc2ncc3cc(C#N)n([C@H]4COC[C@@H]4C)c3n2)c(OC2COC2)n1 |r|

C[C@H](ON(c1cnn(c1)C1COC1)c1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1)C(F)(F)F |r|

C[C@@H](ON(c1cnn(c1)C1COC1)c1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1)C(F)(F)F |r|

CO[C@H]1COC[C@@H]1ON(c1cnn(C)c1)c1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

CO[C@@H]1COC[C@H]1ON(c1cnn(C)c1)c1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

C[C@H]1COC[C@@H]1n1c(cc2cnc(Nc3cn(CS(C)(=O)=O)nc3OC3COC3)nc12)C#N |r|

C[C@H]1COC[C@@H]1n1c(cc2cnc(Nc3cn(C)nc3O[C@@H]3CN(C(C)=O)C3(C)C)nc12)C#N |r|

C[C@H]1COC[C@@H]1n1c(cc2cnc(Nc3cn(C)nc3O[C@H]3CN(C(C)=O)C3(C)C)nc12)C#N |r|

C[C@H]1COC[C@@H]1n1c(cc2cnc(Nc3ccc(cc3OC3COC3)C(C)(C)O)nc12)C#N |r|

C[C@@H](Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1)C(F)(F)F |r|

C[C@H](Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1)C(F)(F)F |r|

C[C@@H]1OC[C@@H]1Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

C[C@H]1OC[C@H]1Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@@H]3C)c2n1 |r|

C[C@@H]1COC[C@H]1n1c(cc2cnc(Nc3cn(C)nc3OC3COC3)nc12)C#N |r|

C[C@@H]1COC[C@@H]1n1c(cc2cnc(Nc3cn(C)nc3OC3COC3)nc12)C#N |r|

C[C@H]1COC[C@H]1n1c(cc2cnc(Nc3cn(C)nc3OC3COC3)nc12)C#N |r|

CC(C)Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@H]3C)c2n1 |r|

CC(C)Oc1nn(cc1Nc1ncc2cc(C#N)n([C@@H]3COC[C@@H]3C)c2n1)[C@H](C)C#N |r|

CC(C)Oc1nn(cc1Nc1ncc2cc(C#N)n([C@@H]3COC[C@@H]3C)c2n1)[C@@H](C)C#N |r|

CC(C)Oc1nn(cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@H]3C)c2n1)[C@H](C)C#N |r|

CC(C)Oc1nn(cc1Nc1ncc2cc(C#N)n([C@H]3COC[C@H]3C)c2n1)[C@@H](C)C#N |r|

Cn1cc(Nc2ncc3cc(C#N)n([C@@H]4CCOC4)c3n2)c(OC2COC2)n1 |r|

Cn1cc(Nc2ncc3cc(C#N)n([C@H]4CCOC4)c3n2)c(OC2COC2)n1 |r|

CO[C@H]1COC[C@H]1n1c(cc2cnc(Nc3cn(OC4COC4)nc3O[C@H](C)C(F)(F)F)nc12)C#N |r|

CO[C@H]1COC[C@H]1n1c(cc2cnc(Nc3ccc(cc3OC3COC3)C(C)(C)O)nc12)C#N |r|

CO[C@H]1COC[C@H]1n1c(cc2cnc(Nc3cn(nc3OC(C)C)[C@H](C)C#N)nc12)C#N |r|

CO[C@H]1COC[C@H]1n1c(cc2cnc(Nc3cn(nc3OC(C)C)[C@@H](C)C#N)nc12)C#N |r|

CO[C@@H]1COC[C@H]1n1c(cc2cnc(Nc3ccc(cc3OC3COC3)C(C)(C)O)nc12)C#N |r|

CO[C@@H]1COC[C@@H]1n1c(cc2cnc(Nc3cn(C)nc3OC(C)C)nc12)C#N |r|

CO[C@H]1COC[C@H]1n1c(cc2cnc(Nc3cn(C)nc3OC(C)C)nc12)C#N |r|

CC(C)Oc1nn(cc1Nc1ncc2cc(C#N)n(C3COC3)c2n1)C(C)(C)C#N

CC(C)Oc1nn(C)cc1Nc1ncc2cc(C#N)n(C3COC3)c2n1

C[C@@H]1OC[C@H]1n1c(cc2cnc(Nc3cn(C)nc3OC3COC3)nc12)C#N |r|

C[C@H]1OC[C@@H]1n1c(cc2cnc(Nc3cn(C)nc3OC3COC3)nc12)C#N |r|

CC(C)Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@H]3CO[C@@H]3C)c2n1 |r|

CC(C)Oc1nn(C)cc1Nc1ncc2cc(C#N)n([C@@H]3CO[C@H]3C)c2n1 |r|

Cn1cc(Nc2ncc3cc(C#N)n(C4CCOCC4)c3n2)c(OC2COC2)n1

Cc1c(Nc2cc3cc(N4CCN(CC4)[C@@]4(C)COC[C@H]4O)c(Cl)cc3cn2)cnn1C1CC1 |r|

Cc1c(Nc2cc3cc(N4CCN(CC4)[C@]4(C)COC[C@@H]4O)c(Cl)cc3cn2)cnn1C1CC1 |r|

CN1CCN(CC1(C)C)c1cc2nc(Nc3cnn(CC(F)F)c3C)ncc2cc1Cl

F[C@H]1CN(CC[C@@H]1n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(COC3)CC2)c1Cl)C1COC1 |r|

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)cnn1CCF

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2CCCC2C#N)cnn1C1CC1

CCn1ncc(Nc2ncc3ccc(cc3n2)N2CCCC2C)c1C

CCn1ncc(Nc2ncc3ccc(cc3n2)N2CCC2C)c1C

C[C@@H]1CC[C@@H](C)N1c1ccc2cnc(Nc3cnn(CCF)c3C)nc2c1 |r|

CN1CCC2(CCN(C2)c2cc3nc(Nc4cnn(CC(C)(C)O)c4Cl)ncc3cc2Cl)C1

CC1(O)CCN(C1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl

OCC1CCN(C1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl

FC(F)Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(CC2)N2CCCC2)c1Cl

O[C@H]1CCN(C1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl |r|

OC1CN(C1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl

OC[C@H]1[C@@H]2CN(C[C@H]12)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl |r|

OC[C@H]1CCN(C1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl |r|

OC1CCN(CC1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl

OC1CN(C1)C1CCN(CC1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl

CN(C)[C@@H]1CCN(C1)c1cc2nc(Nc3cnn(CC(F)F)c3Cl)ncc2cc1Cl |r|

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2COC2)cnn1C1CC1

FC1(F)CN(C1)C1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCn3cnnc3C2)cnn1C1CC1

FC1CN(C1)C1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(CC2)N2CCC2)cnn1C1CC1

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CCC#N)CC2)cnn1C1CC1

CC(=O)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CC(C)(O)CN1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CC1CN(CCN1CC(C)(C)O)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2C[C@@H]3C[C@H]2CN3C2COC2)cnn1C1CC1 |r|

CC1(O)CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

OC1C2CC1CN(C2)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

C[C@@]1(O)[C@H]2CC[C@@H]1CN(C2)c1cc2nc(Nc3cnn(c3)C3CC3)ncc2cc1Cl |r|

OC1CN(C1)C1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CC1(O)CCN(C1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CN(C)[C@@H]1CCN(C1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl |r|

C[C@@]1(O)[C@H]2CC[C@@H]1CN(C2)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl |r|

CC1(O)C2CC1CN(C2)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CN1CCC2CCN(C2C1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CC1CN(C1)C1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(CC2)N2CCCC2)cnn1C1CC1

CC1(COCC1O)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CN(C1COC1)c1ccc2cnc(Nc3cnn(C4CCOCC4)c3C)nc2c1

C[C@H]1COC(=O)N1c1ccc2cnc(Nc3cnn(C4CCOCC4)c3C)nc2c1 |r|

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2(C)COCC2O)cnn1C

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2COCC2O)cnn1C

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2(C)CCOC2)cnn1C12CC(C1)C2

COCC12CC(C1)(C2)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2C[C@@H]3CC[C@H](C2)[C@]3(C)O)c1Cl |r|

O[C@H]1COCC11CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl |r|

O[C@@H]1COCC11CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl |r|

C[C@]1(O)COCC11CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl |r|

C[C@@]1(O)COCC11CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl |r|

CC1(O)CCN(CC1)c1cc2nc(Nc3cnn([C@H]4CCN(C[C@@H]4F)C4COC4)c3Cl)ncc2cc1Cl |r|

OC1CCN(CC1)c1cc2nc(Nc3cnn(c3)C3CC3)ncc2cc1Cl

OC1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CC1(O)CCN(CC1)c1cc2nc(Nc3cnn(c3)C3CC3)ncc2cc1Cl

CC(C)(O)Cn1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(O)CC2)cn1

CC(C)(O)Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(O)CC2)c1Cl

CC(C)(O)Cn1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)cn1

CC(C)(O)Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1Cl

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(O)CC2)cnn1C1CC1

COCC12CC(C1)(C2)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(COC(CO)C3)CC2)cn1

COCC12CC(C1)(C2)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N(C)C)cn1

COCC12CC(C1)(C2)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CC3CCC(C2)O3)c1Cl

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CCC#N)CC2)c1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC(F)C4)c3Cl)ncc2cc1Cl |(8.37,-1.81,;7.83,-3.25,;7.06,-4.59,;8.39,-5.36,;9.16,-4.02,;6.82,-2.09,;7.45,-.68,;6.56,.57,;5.02,.41,;4.39,-.99,;5.29,-2.24,;4.06,1.61,;2.52,1.46,;1.62,2.7,;.09,2.55,;-.81,3.79,;-2.33,3.55,;-2.9,1.96,;-2.16,.62,;-3.21,-.51,;-4.6,.14,;-5.98,-.55,;-7.48,-.21,;-7.83,-1.71,;-9.16,-2.48,;-6.33,-2.05,;-4.42,1.67,;-5.53,2.73,;-.18,5.2,;1.35,5.36,;2.25,4.11,;3.78,4.27,;4.69,3.02,;6.22,3.17,)|

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2COC2)c1Cl

FC(F)(F)C1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2COC2)c1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(c3Cl)C3(CC3)C(F)(F)F)ncc2cc1Cl

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCc3[nH]ncc3C2)cnn1C1CC1

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2C[C@@H]3CC[C@H](C2)[C@]3(C)O)cnn1C1CC1 |r|

OC1C2CC1CN(C2)c1cc2nc(Nc3cnn(c3)C3CC3)ncc2cc1Cl

CN(C)c1cc2nc(Nc3cnn(c3)C3CC3)ncc2cc1Cl

CC(C)(O)Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2C[C@@H]3CC[C@H](C2)[C@]3(C)O)c1Cl |r|

COCC12CC(C1)(C2)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2C[C@@H]3CC[C@H](C2)[C@]3(C)O)cn1 |r|

CC(C)(O)Cn1cc(Nc2ncc3cc(Cl)c(cc3n2)N2C[C@@H]3CC[C@H](C2)[C@]3(C)O)cn1 |r|

COCC12CC(C1)(C2)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(CCOC3)CC2)cn1

COCC12CC(C1)(C2)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(CCCO3)CC2)cn1

COCC12CC(C1)(C2)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1Cl

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(COCC3=O)CC2)cnn1C1CC1

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COCC2O)cnn1C

C[C@@]1(O)[C@H]2CC[C@@H]1CN(C2)c1cc2nc(Nc3cnn(c3Cl)C34CC(C3)C4)ncc2cc1Cl |r|

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(CCOC3)CC2)cnn1C12CC(C1)C2

Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(CCCO3)CC2)cnn1C12CC(C1)C2

C[C@@]1(O)[C@H]2CC[C@@H]1CN(C2)c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl |r|

CN(C)c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl

CNc1cc2nc(Nc3cnn(C4CCN(CC4)C4(C)COC4)c3Cl)ncc2cc1Cl

CCNc1cc2nc(Nc3cnn(C4CCN(CC4)C4(C)COC4)c3Cl)ncc2cc1Cl

CC(C)Nc1cc2nc(Nc3cnn(C4CCN(CC4)C4(C)COC4)c3Cl)ncc2cc1Cl

CC1CN(CCC1(C)O)c1cc2nc(Nc3cnn(C4CC4)c3C)ncc2cc1Cl

O[C@@H]1COC[C@@H]1N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl |r|

CC(C)Nc1ccc2cnc(Nc3cnn(C4CCN(CC4)C4(C)COC4)c3Cl)nc2c1Cl

CC1(O)CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1C#N

Cc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1N1CCC(C)(O)CC1

OC1COCC11CCN(CC1)c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl

OC1COCC1N1CCN(CC1)c1cc2nc(Nc3cnn(c3Cl)C34CC(F)(C3)C4)ncc2cc1Cl

CC1(COCC1O)N1CCN(CC1)c1cc2nc(Nc3cnn(C(F)F)c3Cl)ncc2cc1Cl

CC1(CCOC1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2COCC2O)cnn1C1CC1

Cc1c(N2CCN(CC2)C2(C)COC2)c(Cl)cc2cnc(Nc3cnn(CC(F)(F)F)c3)nc12

Cn1ncc(Nc2ncc3ccc(cc3n2)N2C3CCC(C3)C2=O)c1C(F)(F)F

Cn1ncc(Nc2ncc3ccc(cc3n2)N2C3CCC(C3)C2=O)c1C(F)F

FC(F)(F)Cn1ccc(Nc2ncc3ccc(cc3n2)N2C3CCC(C3)C2=O)n1

CC(C)Nc1ccc2cnc(Nc3cnn(c3)C3CCN(CC3)C3(C)COC3)nc2c1

CC1CCN1c1cc2nc(Nc3cnn(c3)C3CN(CC(C)(C)O)C3)ncc2cc1Cl

CC1CCN1c1cc2nc(Nc3cnn(c3)C3CCN(CC3)C3(C)COC3)ncc2cc1Cl

CCn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c1C

C[C@H]1CN(CCN1C1COC1)c1cc2nc(Nc3cnn(CCF)c3C)ncc2cc1Cl |r|

Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c1C(F)(F)F

CC1(CC1)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)cn1

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(c3)C3CC3)ncc2cc1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(CC(F)(F)F)c3)ncc2cc1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn4CCCc34)ncc2cc1Cl

Cn1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c(n1)C(F)(F)F

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c1Cl

CC1(O)CC2(CN(C2)c2cc3nc(Nc4cnn(c4)C4CC4)ncc3cc2Cl)C1

CC1CCC11CN(C1)c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CC3(C2)CC(C)(O)C3)c1Cl

CC1(O)CC2(CN(C2)c2cc3nc(Nc4cnn(C5CC5)c4Cl)ncc3cc2Cl)C1

CCC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl

CCC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

CC(C)(C)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c1Cl

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(CC2)N2CC(F)(F)C2)c1Cl

CC(C)(C)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(CC2)N2CC(F)(F)C2)c1Cl

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1Cl

CN1CC2CC1CN2c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl

C[C@H]1CN(C)CCN1c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl |r|

CN1CC2(C1)CN(C2)c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CC3(CN(CC(F)(F)F)C3)C2)c1Cl

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(CC2)N2CC(F)C2)c1Cl

CO[C@H]1CCN(C1)c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl |r|

C[C@H]1CN(CCN1C1COC1)c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl |r|

CN1CCC2(CCN(C2)c2cc3nc(Nc4cnn(c4Cl)C4(C)CC4)ncc3cc2Cl)C1

CC1CN(C1)C1CCN(CC1)c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl

CN1CCN(CC1=O)c1cc2nc(Nc3cnn(c3Cl)C3(C)CC3)ncc2cc1Cl

CC1(CC1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCn3cnnc3C2)c1Cl

CC(C)(C)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)cn1

Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(CC4CC4)c3Cl)ncc2cc1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4COC4)c3Cl)ncc2cc1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CCC4)c3Cl)ncc2cc1Cl

CC(C)(O)Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c1Cl

CC1(Cn2ncc(Nc3ncc4cc(Cl)c(cc4n3)N3CCN(CC3)C3(C)COC3)c2Cl)COC1

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(CC4(CC4)C#N)c3)ncc2cc1Cl

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(CC4CCC4)c3Cl)ncc2cc1Cl

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)cnn1CC(C)(C)O

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(c3)C(F)F)ncc2cc1Cl

CC(C)(O)Cn1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)cn1

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl

Cc1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)sn1

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3ccn(CC(F)(F)F)n3)ncc2cc1Cl

CC(C)(C)Cn1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)cn1

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(CC4C[C@@H](F)[C@H](F)C4)c3)ncc2cc1Cl |r|

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(CC4C[C@H](F)[C@@H](F)C4)c3)ncc2cc1Cl |r|

Cc1nscc1Nc1ncc2cc(Cl)c(cc2n1)N1CCN(CC1)C1(C)COC1

CCn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COC2)c1Cl

COC1CC(Cn2ncc(Nc3ncc4cc(Cl)c(cc4n3)N3CCN(CC3)C3(C)COC3)c2Cl)C1 |(-8.33,.89,;-6.8,.7,;-5.87,1.93,;-6.09,3.46,;-4.57,3.68,;-3.64,4.91,;-2.11,4.75,;-1.34,3.41,;.16,3.74,;.32,5.27,;1.66,6.04,;2.99,5.27,;4.33,6.04,;5.66,5.27,;5.66,3.73,;6.99,2.96,;6.99,1.42,;8.33,.65,;5.66,.65,;4.33,1.42,;4.33,2.96,;2.99,3.73,;5.66,-.89,;4.33,-1.66,;4.33,-3.2,;5.66,-3.97,;6.99,-3.2,;6.99,-1.66,;5.66,-5.51,;6.99,-4.74,;4.17,-5.91,;4.57,-7.4,;6.06,-7,;-1.08,5.89,;-1.4,7.4,;-4.35,2.15,)|

CC1(COC1)N1CCN(CC1)c1cc2nc(Nc3cnn(CC4CC4(F)F)c3)ncc2cc1Cl

FC1(F)CC(C1)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl

Cc1cc2cnc(Nc3cnn(C4CC4(F)F)c3Cl)nc2cc1N1CCN(CC1)C1COCC1O

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2COCC2O)cnn1C1CC1(F)F

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2(C)COCC2O)cnn1C1CC1(F)F

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2(C)COCC2O)cnn1C1CC1

Cc1cc2cnc(Nc3cnn(C4CC4(F)F)c3Cl)nc2cc1N1CCN(CC1)C1(C)COCC1O

Cc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1N1CCN(CC1)C1(C)COCC1O

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2COCC2O)cnn1C1CC1

Cc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1N1CCN(CC1)C1COCC1O

Cc1cc2cnc(Nc3cnn(c3Cl)C3(C)CC3)nc2cc1N1CCN(CC1)C1(C)COC1

Cc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1N1CCN(CC1)C1(C)COC1

Cc1c(Nc2ncc3cc(C)c(cc3n2)N2CCN(CC2)C2(C)COC2)cnn1C1CC1

Cc1cc2cnc(Nc3cnn(c3Cl)C34CC(C3)C4)nc2cc1N1CCN(CC1)C1COCC1O

Cc1cc2cnc(Nc3cnn(C4CC4(F)F)c3Cl)nc2cc1N1CCNCC1

Cc1cc2cnc(Nc3cnn(c3Cl)C34CC(F)(C3)C4)nc2cc1N1CCNCC1

Cc1cc2cnc(Nc3cnn(c3Cl)C34CC(C3)C4)nc2cc1N1CC2(CN(C2)C2COCC2O)C1

CC1(COCC1O)N1CCN(CC1)c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl

CCn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1F

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)cnn1C1CC1

CC(C)(O)CC(O)Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1Cl

CC(C)(C#N)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1Cl

Cn1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2COCC2O)c1Cl

Cc1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)sn1

Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)cnn1C1CC1(F)F

CC1(O)CCN(CC1)c1cc2nc(Nc3cnn(c3)C34CC(C3)C4)ncc2cc1Cl

CC1(O)CCN(CC1)c1c(Cl)cc2cnc(Nc3cnn(c3Cl)C34CC(C3)C4)nc2c1Cl

CO[C@H]1C[C@@H](C1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1C |r,wU:4.6,wD:2.1,(-6.67,-1.91,;-5.14,-1.75,;-4.51,-.35,;-3.07,.21,;-3.63,1.64,;-5.06,1.09,;-3,3.05,;-3.77,4.38,;-2.74,5.53,;-1.33,4.9,;0,5.67,;1.34,4.9,;2.67,5.67,;4,4.9,;4,3.36,;5.34,2.59,;5.34,1.05,;6.67,.28,;4,.28,;2.67,1.05,;2.67,2.59,;1.34,3.36,;4,-1.26,;2.67,-2.03,;2.67,-3.57,;4,-4.34,;3.23,-5.67,;4.77,-5.67,;5.34,-3.57,;5.34,-2.03,;-1.49,3.37,;-.35,2.34,)|

CO[C@H]1C[C@H](C1)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC(C)(O)CC2)c1C |r,wU:4.6,2.1,(-6.67,-1.91,;-5.14,-1.75,;-4.51,-.35,;-5.06,1.09,;-3.63,1.64,;-3.07,.21,;-3,3.05,;-3.77,4.38,;-2.74,5.53,;-1.33,4.9,;0,5.67,;1.34,4.9,;2.67,5.67,;4,4.9,;4,3.36,;5.34,2.59,;5.34,1.05,;6.67,.28,;4,.28,;2.67,1.05,;2.67,2.59,;1.34,3.36,;4,-1.26,;2.67,-2.03,;2.67,-3.57,;4,-4.34,;3.23,-5.67,;4.77,-5.67,;5.34,-3.57,;5.34,-2.03,;-1.49,3.37,;-.35,2.34,)|