Found 1473 with Last Name = 'heffernan' and Initial = 't' TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of GLS1 in human A549 cells assessed as reduction in conversion of glutamine to glutamate measured after 24 hrsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of CSF1R phosphorylation in M-CSF induced human THP1 cells incubated for 30 mins by ELISA assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
