TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Binding affinity to wild type BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Binding affinity to FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataKi: 42nMAssay Description:Binding affinity to wild type BCR-ABL T315I mutant (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 0.210nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Inhibition of recombinant wild type Abl (unknown origin) in presence of [33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Binding affinity to human recombinant His-tagged full length ABL1 expressed in baculovirus expression system by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of wild type Abl (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of wild type BCR-ABL phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant PDGFRalpha (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cells incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant Abl-T315I mutant (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type Abl (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant SRC (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Inhibition of BCR-ABL (unknown origin) in presence of [gamma33P]-ATP and ATP by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of His-tagged wild type ABL (229 to 500 residues) (unknown origin) expressed in baculovirus expression system using abltide as substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type Abl (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma33P]-ATP and ATP by ELISA methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of His-tagged ABL-V299L mutant (unknown origin) expressed in baculovirus expression system using abltide as substrate in presence of ATP b...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of TrKA (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 165nMAssay Description:Inhibition of BCR-ABL E255V mutant phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 308nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Hangzhou Medical College
Curated by ChEMBL
Hangzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 666nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+3nMAssay Description:Inhibition of BCR-ABL T315I mutant phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
Affinity DataKd: 3.50E+3nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 400nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 1.80E+4nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 1.60E+3nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 2.67E+5nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 3.00E+3nMAssay Description:In vitro affinity at mutant D2 receptor (S197A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 30nMAssay Description:In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 450nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 1.70E+4nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
Affinity DataKd: 1.30E+4nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair