Affinity DataKi: 0.0190nMAssay Description:Inhibition of human plasma kallikrein by Michaelis-menten analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrateMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Philipps University Marburg
Curated by ChEMBL
Philipps University Marburg
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Inhibition of activated protein kinase C (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.589nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.938nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrate after 10 mins by UV/Vis photometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of human plasma kallikrein using S2302 as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Antagonist activity against human orexin 2 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Antagonist activity against human orexin 2 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Antagonist activity against human orexin 2 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibition of human plasmin by Michaelis-menten analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.49nM ΔG°: -49.9kJ/molepH: 6.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
Affinity DataKi: 2.53nM ΔG°: -49.9kJ/molepH: 8.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 2.69nM ΔG°: -49.7kJ/molepH: 6.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 2.90nM ΔG°: -49.5kJ/molepH: 6.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 2.92nM ΔG°: -49.5kJ/molepH: 8.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Antagonist activity against human orexin 2 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrateMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [125l]orexin A from human orexin 1 receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of human plasmin assessed as reduction in proteolysis activity in presence of fibrinogen after 90 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibition of human plasmin assessed as reduction in proteolysis activity in presence of fibrinogen after 90 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.34nM ΔG°: -49.2kJ/molepH: 6.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 3.58nM ΔG°: -49.0kJ/molepH: 8.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [125l]orexin A from human orexin 2 receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Antagonist activity against human orexin 1 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Antagonist activity against human orexin 1 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 4.53nM ΔG°: -48.4kJ/molepH: 6.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Antagonist activity against human orexin 1 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Antagonist activity against human orexin 2 receptor after 1 hr by Ca2+ sensitive Fluo4-AM fluorescent dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.02nM ΔG°: -48.2kJ/molepH: 8.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 5.03nM ΔG°: -48.2kJ/molepH: 6.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 5.15nM ΔG°: -48.1kJ/molepH: 6.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 5.29nM ΔG°: -48.0kJ/molepH: 8.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...More data for this Ligand-Target Pair