Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Negative allosteric modulation activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx inc...More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Negative allosteric modulation activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in ethidium bromide dye uptake p...More data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Negative allosteric modulation activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx inc...More data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 155nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in ethidium bromide dye uptake preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 211nMAssay Description:Antagonist activity at human P2X4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 350nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 466nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
Affinity DataIC50: 560nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 583nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
Affinity DataIC50: 670nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 680nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 699nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 732nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 796nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in ethidium bromide dye uptake preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 890nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 899nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in ethidium bromide dye uptake preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
Affinity DataIC50: 1.27E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.44E+3nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.46E+3nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.47E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+3nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+3nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.89E+3nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMpH: 7.4 T: 2°CAssay Description:The enzymatic assay of both human and rat ecto-5'-nucleotidase were performed with slight modifications in the previously described method. The stock...More data for this Ligand-Target Pair
Affinity DataIC50: 1.92E+3nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+3nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair