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Found 1659 with Last Name = 'warmus' and Initial = 'j'
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325241(CHEMBL1223114)
Affinity DataKi:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325237((5S,8S,11S)-11-(2-(3,3-diphenylpropanoyloxy)acetyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325240(CHEMBL1223113)
Affinity DataKi:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50200120(CHEMBL260091 | CHIR-090 | US10875832, Compound ChI...)
Affinity DataKi:  2nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325238((5S,8S,11S)-11-(2-(2-benzyl-3-phenylpropanoyloxy)a...)
Affinity DataKi:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325236((5S,8S,11S)-5-isopropyl-8-methyl-11-(2-(2-(naphtha...)
Affinity DataKi:  3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325239(CHEMBL1223112)
Affinity DataKi:  7nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  11nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50478376(BB-78485 | CHEMBL261713)
Affinity DataKi:  20nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255538((4-(4-(3-chlorobenzyloxy)-3-methylbenzoyl)piperazi...)
Affinity DataKi:  23.9nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255483(4-(3-chloro-4-(3-chlorobenzyloxy)benzoyl)-1-methyl...)
Affinity DataKi:  37.2nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50074960((R)-2-(3,4-Dimethoxy-5-propyl-phenyl)-4,5-dihydro-...)
Affinity DataKi:  50nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
TargetHigh affinity choline transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50071542((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-5-[2-(...)
Affinity DataKi:  82nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255768(2-(4-chloro-5-(3-chlorobenzyloxy)pyridin-2-yl)-1,3...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255662(3-chloro-4-(3-chlorobenzyloxy)-N-(4-hydroxybutyl)b...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50071543((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-4-oxo-...)
Affinity DataKi:  113nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325235((5S,8S,11S)-5-isopropyl-8-methyl-3,6,9-trioxo-1-ph...)
Affinity DataKi:  134nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133601(CHEMBL3633251)
Affinity DataKi:  151nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133602(CHEMBL3633250)
Affinity DataKi:  174nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  250nMAssay Description:Inhibition of human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)
Affinity DataKi:  316nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133596(CHEMBL3633459)
Affinity DataKi:  347nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133603(CHEMBL3633248)
Affinity DataKi:  372nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325250((S)-3-(benzyloxycarbonylamino)-5-(2-(naphthalen-1-...)
Affinity DataKi:  500nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50133600(CHEMBL3633457)
Affinity DataKi:  501nMAssay Description:Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325259((S)-5-(2-(1H-indol-3-yl)acetoxy)-3-(benzyloxycarbo...)
Affinity DataKi:  600nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483375(CHEMBL1236446)
Affinity DataKi:  650nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325257((S)-3-(benzyloxycarbonylamino)-5-(3,3-diphenylprop...)
Affinity DataKi:  800nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325260((S)-5-(2-(benzofuran-3-yl)acetoxy)-3-(benzyloxycar...)
Affinity DataKi:  800nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325252((3S)-3-(benzyloxycarbonylamino)-5-(2-(naphthalen-1...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325251((S)-3-(benzyloxycarbonylamino)-5-(2-(naphthalen-1-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]Dofetilide from recombinant human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325258((3S)-3-(benzyloxycarbonylamino)-4-oxo-5-(3-phenyl-...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325246((S)-3-(benzyloxycarbonylamino)-4-oxo-5-(2-(phenylt...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325261((S)-5-(2-(benzo[b]thiophen-3-yl)acetoxy)-3-(benzyl...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325249((S)-3-(benzyloxycarbonylamino)-5-(2-(naphthalen-2-...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325254((S)-3-(benzyloxycarbonylamino)-5-(2-(4-methylnapht...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50365344(CHEMBL1956115)
Affinity DataKi:  1.35E+3nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325234(CHEMBL1223107)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325245((S)-3-(benzyloxycarbonylamino)-4-oxo-5-(2-phenoxya...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325255((S)-3-(benzyloxycarbonylamino)-5-(2-(5-methylnapht...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  2.12E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50275437(CHEMBL4129620)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of dofetilide binding to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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