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Found 43 with Last Name = 'wetterau' and Initial = 'jr'
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098322(9-(4-{5-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Affinity DataIC50:  0.0200nMAssay Description:In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098321(9-(4-{2,5-Dimethyl-4-[(4'-trifluoromethyl-biphenyl...)
Affinity DataIC50:  0.0300nMAssay Description:In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098326(9-(4-{2-Isopropyl-4-[(4'-trifluoromethyl-biphenyl-...)
Affinity DataIC50:  0.0600nMAssay Description:In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098324(9-(4-{2-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Affinity DataIC50:  0.150nMAssay Description:In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098325(9-(4-{4-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-...)
Affinity DataIC50:  0.240nMAssay Description:In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098320(9-(4-{4-[(4''-Trifluoromethyl-biphenyl-2-carbonyl)...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098324(9-(4-{2-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098322(9-(4-{5-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098321(9-(4-{2,5-Dimethyl-4-[(4'-trifluoromethyl-biphenyl...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098323(9-(4-{2-Propyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098326(9-(4-{2-Isopropyl-4-[(4'-trifluoromethyl-biphenyl-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098325(9-(4-{4-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of human Microsomal Triglyceride Transfer Protein (triglyceride transfer assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098320(9-(4-{4-[(4''-Trifluoromethyl-biphenyl-2-carbonyl)...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of human microsomal triglyceride transfer protein using triglyceride transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50098327(9-(3-{4-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150998(((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150998(((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28680(2-[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)am...)
Affinity DataIC50:  316nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28680(2-[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)am...)
Affinity DataIC50:  538nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50163728((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50163728((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150998(((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...)
Affinity DataEC50:  110nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataEC50: >3.20E+4nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150998(((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...)
Affinity DataEC50:  320nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataEC50:  140nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50163728((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Affinity DataEC50:  1.50E+3nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM28680(2-[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)am...)
Affinity DataEC50:  425nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataEC50:  1.39E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20879(C-aryl glucoside, 5 | CHEMBL429911 | N-ethyl-2,6-d...)
Affinity DataEC50: >8.00E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50: >8.00E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataEC50:  211nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataEC50:  330nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataEC50:  1.10nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20879(C-aryl glucoside, 5 | CHEMBL429911 | N-ethyl-2,6-d...)
Affinity DataEC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50:  9.20nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50163728((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Affinity DataEC50:  20nMAssay Description:Effective concentration against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataEC50:  35.6nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataEC50:  6.60nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed