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Found 167 with Last Name = 'whitney' and Initial = 'j'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50007518((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)
Affinity DataKi:  0.190nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50007522(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008783(CHEMBL42448 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Affinity DataKi:  0.25nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.270nMAssay Description:Compound was evaluated for binding affinity towards Dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the absence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50007522(5-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dime...)
Affinity DataKi:  0.760nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008786(CHEMBL43506 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Affinity DataKi:  0.770nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008786(CHEMBL43506 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008783(CHEMBL42448 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50007518((S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)me...)
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008785(CHEMBL42953 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-...)
Affinity DataKi:  1.20nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008788(CHEMBL42260 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008784(CHEMBL288704 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5...)
Affinity DataKi:  1.40nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  1.40nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for binding affinity towards Dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the absence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  2.20nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008785(CHEMBL42953 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-...)
Affinity DataKi:  4.40nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008782(CHEMBL44237 | EPIDEPRIDE | Epidepride;N-(1-Ethyl-p...)
Affinity DataKi:  5nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008784(CHEMBL288704 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50008787(CHEMBL43552 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2,...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50005118((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008786(CHEMBL43506 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Affinity DataKi:  9.5nMAssay Description:binding affinity towards alpha-2 adrenergic receptor, using [3H]- atipamezole as radioligand from rat frontal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008783(CHEMBL42448 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-...)
Affinity DataKi:  11nMAssay Description:Compound was evaluated for binding affinity towards dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50005118((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50007523(CHEMBL295621 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50453046(CHEMBL2114461)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University of California

Curated by ChEMBL
LigandPNGBDBM50453047(CHEMBL2114460)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015453(CHEMBL3265037)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015454(CHEMBL3264995)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015447(CHEMBL3265031)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015460(CHEMBL3265001)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

LigandPNGBDBM36516(4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...)
Affinity DataIC50:  1.90nM Kd:  1.5nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015449(CHEMBL3265033)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015459(CHEMBL3265000)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015439(CHEMBL3265024)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015457(CHEMBL3264998)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015425(CHEMBL3265016)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015450(CHEMBL3265034)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015427(CHEMBL3265017)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015446(CHEMBL3265030)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015458(CHEMBL3264999)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015442(CHEMBL3265026)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015428(CHEMBL3265018)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015445(CHEMBL3265029)
Affinity DataIC50:  7nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015451(CHEMBL3265035)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015448(CHEMBL3265032)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Affinity DataIC50:  8nM Kd:  25nMAssay Description:Biochemical binding assays (DiscoveRx) and in vitro enzyme inhibition assays (LanthaScreen, Life Technologies) were conducted to determine the bindin...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015444(CHEMBL3265028)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015430(CHEMBL3265020)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50015456(CHEMBL3264997)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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