BindingDB PrimarySearch

Found 937 with Last Name = 'yue' and Initial = 'q'

Urease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL

Ki: 372nMAssay Description:Inhibition of Helicobacter pylori urease using urea as substrate assessed as inhibition constant for enzyme-urea-inhibitor complex by non-linear fitt...More data for this Ligand-Target Pair

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Urease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL

BDBM50534504(CHEMBL4590676)

Ki: 404nMAssay Description:Inhibition of Helicobacter pylori urease using urea as substrate assessed as inhibition constant for enzyme-inhibitor complex by non-linear fitting a...More data for this Ligand-Target Pair

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Urease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL

BDBM50493364(CHEMBL2425480)

Ki: 1.20E+3nMAssay Description:Inhibition of Helicobacter pylori urease using urea as substrate assessed as inhibition constant for enzyme-urea-inhibitor complex by non-linear fitt...More data for this Ligand-Target Pair

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Urease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL

BDBM50493364(CHEMBL2425480)

Ki: 4.74E+3nMAssay Description:Inhibition of Helicobacter pylori urease using urea as substrate assessed as inhibition constant for enzyme-inhibitor complex by non-linear fitting a...More data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394918(CHEMBL2165504)

Ki: 6.60E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes preincubated for 30 minsMore data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394917(CHEMBL2165505)

Ki: 7.80E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes preincubated for 30 minsMore data for this Ligand-Target Pair

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Urease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL

BDBM24961(Urea)

Ki: 6.47E+6nMAssay Description:Substrate inhibition of Helicobacter pylori urease in presence of >4 mM urea by indophenol methodMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043407(CHEMBL3355476)

IC50: 0.100nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM202656(US10245267, Example 1 | US10709712, Example 1 | US...)

IC50: 0.100nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043409(CHEMBL3355474)

IC50: 0.200nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM88120(US10245267, Example 1156 | US10709712, Example 115...)

IC50: 0.200nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM202686(US10245267, Example 31 | US10709712, Example 31 | ...)

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043385(CHEMBL3355072)

IC50: 0.300nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM87998(US10245267, Example 1029 | US10709712, Example 103...)

IC50: 0.300nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM88120(US10245267, Example 1156 | US10709712, Example 115...)

IC50: 0.400nMAssay Description:Inhibition of full-length BRAF (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM202784(US10245267, Example 131 | US10709712, Example 131 ...)

IC50: 0.400nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043408(CHEMBL3355475)

IC50: 0.400nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM84365(US10245267, Example 636 | US10709712, Example 636 ...)

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043387(CHEMBL3355074)

IC50: 0.400nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394916(CHEMBL2165506)

IC50: 0.480nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043411(CHEMBL3355480)

IC50: 0.5nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043384(CHEMBL3355071)

IC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043382(CHEMBL3355069)

IC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50510891(CHEMBL4455996)

IC50: 0.600nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394910(CHEMBL2165512)

IC50: 0.670nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM88006(US10245267, Example 1041 | US10709712, Example 104...)

IC50: 0.700nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50510890(CHEMBL4593446)

IC50: 0.900nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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L-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597908(CHEMBL5181496)

IC50: 0.900nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair

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L-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597908(CHEMBL5181496)

IC50: 0.900nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043383(CHEMBL3355070)

IC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043386(CHEMBL3355073)

IC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043410(CHEMBL3355473)

IC50: 1nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394913(CHEMBL2165509)

IC50: 1.10nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

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Neuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL

BDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)

IC50: 1.10nMAssay Description:Inhibition of alpha-4-beta-2 nAChRMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM202839(US10245267, Example 640 | US10709712, Example 191 ...)

IC50: 1.10nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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L-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597906(CHEMBL5183539)

IC50: 1.60nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair

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L-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597915(CHEMBL5185237)

IC50: 1.70nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50510889(CHEMBL4475855)

IC50: 1.70nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

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L-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597915(CHEMBL5185237)

IC50: 1.70nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394920(CHEMBL2165672)

IC50: 1.70nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394921(CHEMBL2165671)

IC50: 1.80nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

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L-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597916(CHEMBL5201115)

IC50: 1.80nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair

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L-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597916(CHEMBL5201115)

IC50: 1.80nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394908(CHEMBL2165666)

IC50: 1.80nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50043389(CHEMBL3352844)

IC50: 2nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair

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L-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597896(CHEMBL5181996)

IC50: 2.20nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair

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L-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597896(CHEMBL5181996)

IC50: 2.20nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair

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L-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597916(CHEMBL5201115)

IC50: 2.20nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair

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L-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50597916(CHEMBL5201115)

IC50: 2.20nMAssay Description:Inhibition of LDHB (unknown origin)More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50394893(CHEMBL2165502)

IC50: 2.30nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

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Displayed 1 to 50 (of 937 total ) | Next | Last >>

Filter my 937 hits

Targets 34▿
- L-lactate dehydrogenase A chain 414
- L-lactate dehydrogenase B chain 165
- Potassium voltage-gated channel subfamily H member 2 54
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 43
- Urease subunit beta 30
- Dual specificity mitogen-activated protein kinase kinase 1 29
- Serine/threonine-protein kinase ATR 27
- Cytochrome P450 3A4 25
- RAF proto-oncogene serine/threonine-protein kinase 22
- Probable global transcription activator SNF2L2 19
- Transcription activator BRG1 13
- Serine/threonine-protein kinase Chk1 11
- Cytochrome P450 1A2 9
- Cytochrome P450 2C9 9
- Cytochrome P450 2D6 9
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 8
- Serine/threonine-protein kinase mTOR 6
- DNA gyrase subunit A/B 5
- Sodium channel protein type 5 subunit alpha 5
- Serine-protein kinase ATM 4
- DNA-dependent protein kinase catalytic subunit 4
- Serine/threonine-protein kinase WNK1 [198-401] 4
- Malate dehydrogenase, mitochondrial 3
- Malate dehydrogenase, cytoplasmic 3
- Voltage-dependent L-type calcium channel subunit alpha-1C 3
- Serine/threonine-protein kinase WNK1 [1-491] 3
- Neuronal acetylcholine receptor subunit alpha-4/beta-2 2
- Serine/threonine-protein kinase B-raf 2
- Discoidin domain-containing receptor 2 1
- Serine/threonine-protein kinase WNK2 [166-489] 1
- Serine/threonine-protein kinase WNK4 [1-444] 1
- Platelet-derived growth factor receptor beta 1
- Epithelial discoidin domain-containing receptor 1 1
- Serine/threonine-protein kinase WNK3 [1-434] 1
- ...
Publications 18▿
- Bioorg Med Chem Lett 24: 3764-71 (2014) 185
- Bioorg Med Chem Lett 59: (2022) 102
- Bioorg Med Chem Lett 23: 5533-9 (2013) 91
- ACS Med Chem Lett 7: 896-901 (2016) 82
- Bioorg Med Chem Lett 23: 3186-94 (2013) 69
- J Med Chem 55: 5887-900 (2012) 59
- J Med Chem 64: 6329-6357 (2021) 53
- Bioorg Med Chem Lett 24: 5683-7 (2014) 43
- Bioorg Med Chem Lett 25: 75-82 (2015) 41
- ACS Med Chem Lett 6: 42-6 (2015) 37
- ACS Med Chem Lett 6: 37-41 (2015) 36
- J Med Chem 61: 10155-10172 (2018) 32
- Bioorg Med Chem 24: 4519-4527 (2016) 30
- J Med Chem 55: 4594-604 (2012) 29
- J Med Chem 63: 2013-2027 (2020) 28
- ACS Chem Biol 11: 3338-3346 (2016) 10
- J Med Chem 63: 7773-7816 (2020) 8
- Bioorg Med Chem Lett 17: 6245-9 (2007) 2
Institutions 5▿
- Genentech 672
- Novartis Institutes For Biomedical Research 204
- Jishou University 30
- Argenta Discovery 29
- Peking University 2
Affinity: 0.10 to 6.5E+6 nM▿
- Ki 7
- IC50 825
- Kd 75
- EC50 30
- Affinity ≤ nM
Xtal structures: 22
Docked structures: 0
Catalog Cmpds: 32