Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 50029501,50029513,50046890,50073316,50286441,50029501,50029513,50046890,50073316,50286441   

TargetCathepsin B(Goat)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  0.0200nMAssay Description:Competitive inhibition of goat brain cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 2.5nMAssay Description:Compound was measured for inhibition of collagenolytic of human Cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human cathepsin L.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  7nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetCathepsin B(Human)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  7nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Medical University of Bialystok

LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  8nMpH: 7.5Assay Description:Buffer and 0.1 mL of enzyme solution was added to 0.2 mL of examined compounddissolved in 0.15 M NaCl (as control 0.15 M NaCl). The buffer and the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details Article
PubMed
TargetPlasminogen(Human)
Medical University of Bialystok

LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  8.20nMpH: 7.4Assay Description:Buffer and 0.1 mL of enzyme solution was added to 0.2 mL of examined compounddissolved in 0.15 M NaCl (as control 0.15 M NaCl). The buffer and the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details Article
PubMed
TargetCathepsin B(Human)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetCysteine protease(Leishmania donovani)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Leishmania donovani cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetCathepsin B(Goat)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  13nMAssay Description:Competitive inhibition of goat brain cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetProthrombin(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataKi:  15nMAssay Description:The inhibitory activity against thrombin (IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataKi:  15nMAssay Description:Binding affinity against Thrombin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataIC50: 17nMAssay Description:Inhibition against platelet aggregation without interacting directly with the nucleophilic serine of thrombin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50: 19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 47nMAssay Description:Inhibition of cathepsin B by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50: 53nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  61nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCysteine proteinase falcipain 2a(malaria parasite P. falciparum)
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 87nMAssay Description:Inhibition of Cysteine protease falcipain-2 in Plasmodium falciparum HB3 infected erythrocytes by Z-Phe-Arg-AMC substrate hydrolysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCysteine proteinase falcipain 3(Plasmodium falciparum (isolate 3D7))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 87nMAssay Description:Inhibition of Cysteine protease falcipain-3 in Plasmodium falciparum HB3 infected erythrocytes by Z-Phe-Arg-AMC substrate hydrolysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCysteine proteinase falcipain 2a(malaria parasite P. falciparum)
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 98nMAssay Description:Inhibition of Cysteine protease falcipain-2 in Plasmodium falciparum HB3-leuR1 mutant infected erythrocytes by Z-Phe-Arg-AMC substrate hydrolysis ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCysteine proteinase falcipain 3(Plasmodium falciparum (isolate 3D7))
National Institute of Allergy and Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 98nMAssay Description:Inhibition of Cysteine protease falcipain-3 in Plasmodium falciparum HB3-leuR1 mutant infected erythrocytes by Z-Phe-Arg-AMC substrate hydrolysis ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor activator(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  188nMAssay Description:Inhibition of recombinant HGFA (unknown origin) using Boc-QLR-AMC as substrate by chromogenic proteolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetTrypsin(Pig)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 200nMAssay Description:Inhibition of pig pancreas trypsin type IX-SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 310nMAssay Description:Inhibition of cathepsin B with Cbz-L-lysine-p-nitrophenyl ester as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetTrypsin(Pig)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 500nMAssay Description:Inhibition of pig pancreas trypsin type IX-S using Boc-Gln-Ala-Arg-MCA substrate by 7-amino-4-methylcoumarin release based spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50: 550nMAssay Description:In vitro Enzyme Inhibitory activity measured against Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataKi:  675nMAssay Description:The inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  696nMAssay Description:Inhibition of matriptase (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPlasminogen(Human)
Medical University of Bialystok

LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50: 710nMAssay Description:In vitro Enzyme Inhibitory activity measured against PlasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Medical University of Bialystok

LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human recombinant matriptase catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of human recombinant matriptase 2 expressed in HEK293 cells in conditioned medium after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029513((S)-1-((4aS,8aS)-Decahydro-isoquinoline-3-carbonyl...)
Affinity DataIC50: 3.30E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029513((S)-1-((4aS,8aS)-Decahydro-isoquinoline-3-carbonyl...)
Affinity DataIC50: 3.30E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029513((S)-1-((4aS,8aS)-Decahydro-isoquinoline-3-carbonyl...)
Affinity DataIC50: 3.30E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029513((S)-1-((4aS,8aS)-Decahydro-isoquinoline-3-carbonyl...)
Affinity DataIC50: 3.30E+3nMAssay Description:In vitro Enzyme Inhibitory activity against t-PA(Tissue plasminogen activator).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Medical University of Bialystok

LigandPNGBDBM50029513((S)-1-((4aS,8aS)-Decahydro-isoquinoline-3-carbonyl...)
Affinity DataIC50: 3.30E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against PlasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Bovine)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of plasmin with Val-L-Leu-L-lysine-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  4.10E+3nMAssay Description:Inhibition of human purified matriptase 2 catalytic domain expressed in HEK293 cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of trypsin with benzoyl-L-arginine ethyl ester as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of human liver cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Kurukshetra University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of human liver cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of thrombin with benzoyl-Phe-Val-arginine- p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetPlasminogen(Bovine)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50046890(2-Acetylamino-4-methyl-pentanoic acid [1-(5-amino-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of plasmin with Val-L-Leu-L-lysine-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50046890(2-Acetylamino-4-methyl-pentanoic acid [1-(5-amino-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of thrombin with benzoyl-Phe-Val-arginine- p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50046890(2-Acetylamino-4-methyl-pentanoic acid [1-(5-amino-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of trypsin with benzoyl-L-arginine ethyl ester as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50046890(2-Acetylamino-4-methyl-pentanoic acid [1-(5-amino-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of cathepsin B with Cbz-L-lysine-p-nitrophenyl ester as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataIC50: 2.24E+4nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
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