Report error Found 152 Enz. Inhib. hit(s) with Target = 'Bifunctional purine biosynthesis protein ATIC'
Affinity DataKi: 6nMAssay Description:Inhibition of human AICARFTMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of recombinant human AICARFTase using AICAR as substrate incubated at 37 degC for 30 mins measured after overnight incubation at 4 degCMore data for this Ligand-Target Pair
Affinity DataKi: 130nM ΔG°: -38.9kJ/molepH: 7.4 T: 22°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
Affinity DataKi: 150nM ΔG°: -38.6kJ/molepH: 7.4 T: 22°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
Affinity DataKi: 154nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
Affinity DataKi: 230nM ΔG°: -37.5kJ/molepH: 7.4 T: 22°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
Affinity DataKi: 685nM ΔG°: -35.2kJ/moleT: 25°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
Affinity DataKi: 880nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 1.07E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 2.50E+3nM ΔG°: -32.0kJ/moleT: 25°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition constant against AICAR formyltransferaseMore data for this Ligand-Target Pair
Affinity DataKi: 5.15E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 7.10E+3nM ΔG°: -29.1kJ/mole IC50: 1.16E+4nMpH: 7.5 T: 22°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
Affinity DataKi: 8.00E+3nMAssay Description:Inhibition constant against AICAR formyltransferaseMore data for this Ligand-Target Pair
Affinity DataKi: 8.03E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 8.37E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 9.48E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 1.45E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 1.70E+4nMAssay Description:In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.98E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nM ΔG°: -26.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nM ΔG°: -26.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
Affinity DataKi: 2.20E+4nMAssay Description:Inhibition of AICAR transformylase (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.47E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Affinity DataKi: 4.60E+4nMAssay Description:Inhibition of human recombinant AICAR TfaseMore data for this Ligand-Target Pair
Affinity DataKi: 5.20E+4nMAssay Description:In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylaseMore data for this Ligand-Target Pair
Affinity DataKi: 5.60E+4nM ΔG°: -24.3kJ/moleT: 25°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
Affinity DataKi: 5.90E+4nM ΔG°: -24.1kJ/moleT: 25°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
Affinity DataKi: 8.40E+4nM ΔG°: -23.3kJ/moleT: 25°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
Affinity DataKi: 8.70E+4nM ΔG°: -23.2kJ/moleT: 25°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human aminoimidazole carboxamide transformylaseMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant AICAR TfaseMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant AICAR TfaseMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant AICAR TfaseMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant AICAR TfaseMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 22°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 22°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 22°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
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