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Report error Found 30 Enz. Inhib. hit(s) with Target = 'Urease' and Ligand = 'BDBM50229993'
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 560nMAssay Description:Inhibition of jack bean urease using urea as substrate pretreated for 15 mins followed by substrate addition by phenol red based spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2019
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 1.95E+4nMpH: 6.8 T: 2°CAssay Description:To understand the binding modes of the compounds given in Table 1, all ligands were docked into the binding site of Urease enzyme. The top ranked con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of jack bean urease using urea as substrate assessed as ammonia production incubated for 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataKi:  1.96E+4nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataKi:  2.00E+4nM IC50: 2.10E+4nMpH: 6.8Assay Description:Reaction mixtures consisting of 25 μL (1 unit/well) of Jack bean (Canavalia ensiformis) urease, 55 μL of buffer at pH 6.8, 100 mM of urea, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent

TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataKi:  2.00E+4nM IC50: 2.10E+4nMAssay Description:Reaction mixture consisting of 25 µL of Jack bean (Canavalia ensiformis) urease (1 unit/well), 55 µL of 100 mM urea dissolved in phosphate buffer (4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataKi:  2.00E+4nMAssay Description:Competitive inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by Lineweaver-Burk/Dixon plot analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate incubated for 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.09E+4nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Reaction mixtures comprising 25 μL of enzyme (jack bean urease) solution and 55 μL of buffers containing 100 mM urea were incubated with 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of jack bean Urease assessed as ammonia production after 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of jack bean urease by phenol red methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:The synthesized compounds (4a-e, 5a-e) were tested for their in vitro urease inhibition activities at 0.2 mM concentration against jack bean urease. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of Canavalia ensiformis (jack bean) urease assessed as inhibition of ammonia production after 15 min by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMpH: 6.8 T: 2°CAssay Description:Mixture of 25 μL of urease enzyme (Jack bean) solution containing 1 unit of enzyme (1 unit = 0.02 mg of enzyme) was dissolved in phosphate buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of Canavalia ensiformis (jack bean) urease using urea as substrate after 15 min by indophenol-based spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by Weatherburn assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition assay using urease from jack bean.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.10E+4nMpH: 6.8 T: 2°CAssay Description:Reaction mixtures comprising 25 μL of enzyme (jack bean urease) solution and 55 μL of buffer containing 100 mM urea were incubated with 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.11E+4nMAssay Description:In vitro inhibition assay using jack bean urease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.13E+4nMAssay Description:Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate after 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.13E+4nMAssay Description:Inhibition of jack beans urease assessed as hydrolysis of urea into ammonia preincubated for 10 mins followed by urea addition measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of jack bean urease assessed as reduction in ammonia production incubated at 30 degC for 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of jack bean urease using urea as substrate assessed as reduction in ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of Canavalia ensiformis (jack bean) urease assessed as release of ammonia after 30 min by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 6.83E+5nMAssay Description:Inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
Recep Tayyip Erdogan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229993BDBM50229993(thiocarbamide | thiocarbonic acid diamide | Thioha...)
Affinity DataIC50: 6.83E+5nMAssay Description:Inhibition of Jack bean urease using urea as substrate assessed as production of ammonia after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed