Compile Data Set for Download or QSAR
Report error Found 1304 of kd for UniProtKB: P36888
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601440BDBM50601440(CHEMBL5176837)
Affinity DataKd:  0.0100nMAssay Description:Binding affinity to FLT3-ITD-D835V mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593961BDBM50593961(CHEMBL5195819)
Affinity DataKd:  0.0154nMAssay Description:Binding affinity to FLT3 ITD/F691L double mutant (unknown origin) by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.0170nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621126BDBM621126(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0170nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621115BDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0240nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538621BDBM538621(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Affinity DataKd:  0.0250nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621098BDBM621098(6-(6-(difluorometh- oxy)imidazo[1,2-a]- pyridin-3-...)
Affinity DataKd:  0.0290nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.0340nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621169BDBM621169(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0350nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.0560nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621130BDBM621130(N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-...)
Affinity DataKd:  0.0600nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538619BDBM538619(NCGC 00371479 | US11254667, Compound I-22 | US1154...)
Affinity DataKd:  0.0650nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.0740nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621117BDBM621117(2-(3-(6-(((3S,4S)-4- fluoropiperidin-3- yl)amino)p...)
Affinity DataKd:  0.0740nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621165BDBM621165(Exemplary Synthetic Procedure #38 | US20230303563...)
Affinity DataKd:  0.0750nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621166BDBM621166(N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...)
Affinity DataKd:  0.0800nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621168BDBM621168(6-(6-(1-cyclopropyl-1H- pyrazol-4-yl)imidazo- [1,2...)
Affinity DataKd:  0.0850nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.100nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621125BDBM621125((R)-N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridi...)
Affinity DataKd:  0.140nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 185149BDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataKd:  0.150nMAssay Description:Binding affinity to non-auto-inhibited form of wild type human N-terminal GST-tagged FLT3 expressed in baculovirus expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 185149BDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataKd:  0.160nMAssay Description:Binding affinity to human FLT3 D835H mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.160nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621116BDBM621116(2-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3- yl)amino)...)
Affinity DataKd:  0.170nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476165BDBM50476165(CHEMBL6083120)
Affinity DataKd: <0.170nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476165BDBM50476165(CHEMBL6083120)
Affinity DataKd: <0.170nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476164BDBM50476164(CHEMBL6077980)
Affinity DataKd: <0.170nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621123BDBM621123(US20230303563, Compound 165)
Affinity DataKd:  0.170nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476165BDBM50476165(CHEMBL6083120)
Affinity DataKd: <0.170nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476164BDBM50476164(CHEMBL6077980)
Affinity DataKd: <0.170nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476164BDBM50476164(CHEMBL6077980)
Affinity DataKd: <0.170nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476165BDBM50476165(CHEMBL6083120)
Affinity DataKd: <0.170nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476164BDBM50476164(CHEMBL6077980)
Affinity DataKd: <0.170nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.180nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476165BDBM50476165(CHEMBL6083120)
Affinity DataKd:  0.190nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476165BDBM50476165(CHEMBL6083120)
Affinity DataKd:  0.200nMAssay Description:In vitro inhibitory concentration against cathepsin K in cell-based assay of bone resorptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 185149BDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataKd:  0.200nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621161BDBM621161(N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...)
Affinity DataKd:  0.210nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621137BDBM621137(3,5-difluoro-N-((3S,4S)-4- fluoropiperidin-3-yl)-6...)
Affinity DataKd:  0.220nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.220nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476165BDBM50476165(CHEMBL6083120)
Affinity DataKd:  0.220nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.220nMAssay Description:Binding constant for FLT3(R834Q) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270298BDBM50270298(CHEMBL4075720)
Affinity DataKd:  0.230nMAssay Description:Binding affinity to human FLT3 ITD/D835V double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataKd:  0.230nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621167BDBM621167(1-(4-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3-yl)- am...)
Affinity DataKd:  0.240nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476166BDBM50476166(CHEMBL6078253)
Affinity DataKd:  0.240nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50564363BDBM50564363(CHEMBL4791998)
Affinity DataKd: <0.25nMAssay Description:Binding affinity to human FLT3 ITD mutant in presence of ATP by Lanthascreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536008BDBM50536008(CHEMBL4550647)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to human partial length FLT3 D835V mutant (592 to 969 residues) expressed in mammalian expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 185149BDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataKd:  0.260nMAssay Description:Binding affinity to human FLT3 ITD mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601440BDBM50601440(CHEMBL5176837)
Affinity DataKd:  0.290nMAssay Description:Binding affinity to FLT3-TKD-D835H mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601440BDBM50601440(CHEMBL5176837)
Affinity DataKd:  0.290nMAssay Description:Binding affinity to FLT3-TKD-D835Y mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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