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Found 190 of kd for UniProtKB: P52333
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM477067(US10882859, Example 2(a))
Affinity DataKd:  0.0460nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM477066(US10882859, Example 1)
Affinity DataKd:  0.0980nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50426601(CHEMBL2325895)
Affinity DataKd:  0.120nMAssay Description:Binding affinity to JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  0.160nMAssay Description:Binding constant for JAK3(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  0.700nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild type human partial length JAK3 (I781 to S1124 residues) expressed in mammalian expression system by Kinomescan binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)
Affinity DataKd:  1.34nMAssay Description:The assay is based on the displacement of a reporter probe by a test compound. Close proximity of the probe and the targeted kinase result in emissio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50433252(CHEMBL2376144)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to JAK3 (unknown origin) by ligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM374723((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Affinity DataKd:  1.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM374723((13R)-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,...)
Affinity DataKd:  1.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM477065(US10882859, Reference compound PF-06263276)
Affinity DataKd:  1.90nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKd:  2nMAssay Description:Binding constant for JAK3(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  2.20nMAssay Description:Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  2.30nMAssay Description:Binding constant for JAK3(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to JH1 catalytic domain of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)
Affinity DataIC50:  0.800nM Kd:  2.70nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)
Affinity DataKd:  2.70nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)
Affinity DataKd:  2.70nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)
Affinity DataKd:  2.70nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)
Affinity DataKd:  2.70nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)
Affinity DataKd:  2.70nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)
Affinity DataKd:  2.70nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  2.90nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  2.90nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  2.90nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  2.90nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  2.90nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  2.90nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100348(US10533001, Example Table 9a.1 | US11414410, Table...)
Affinity DataKd:  2.90nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100349(US10533001, Example Table 9a.2 | US11414410, Table...)
Affinity DataKd:  3nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100349(US10533001, Example Table 9a.2 | US11414410, Table...)
Affinity DataKd:  3nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100349(US10533001, Example Table 9a.2 | US11414410, Table...)
Affinity DataKd:  3nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100349(US10533001, Example Table 9a.2 | US11414410, Table...)
Affinity DataKd:  3nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100351(US10533001, Example Table 9a.4 | US11414410, Table...)
Affinity DataKd:  4.10nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100351(US10533001, Example Table 9a.4 | US11414410, Table...)
Affinity DataKd:  4.10nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100351(US10533001, Example Table 9a.4 | US11414410, Table...)
Affinity DataKd:  4.10nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM100351(US10533001, Example Table 9a.4 | US11414410, Table...)
Affinity DataKd:  4.10nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100351(US10533001, Example Table 9a.4 | US11414410, Table...)
Affinity DataKd:  4.10nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100351(US10533001, Example Table 9a.4 | US11414410, Table...)
Affinity DataKd:  4.10nMAssay Description:This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM100351(US10533001, Example Table 9a.4 | US11414410, Table...)
Affinity DataKd:  4.10nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM374722(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Affinity DataKd:  4.30nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM374722(11-fluoro-13-methyl-6,7,13,14-tetrahydro-1,15- eth...)
Affinity DataKd:  4.30nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM214689(US9295672, (S)-(4-fluorophenyl)(4-((5-methyl-1H-py...)
Affinity DataKd:  5nMAssay Description:Inhibition of JAK3 (unknown origin) assessed as dissociate constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKd:  8.20nMAssay Description:Binding constant for JAK3(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  10nMAssay Description:Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412)
Affinity DataKd:  12nMAssay Description:Binding affinity to JH1 catalytic domain of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
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US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  12nMAssay Description:Binding constant for JAK3(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412)
Affinity DataKd:  12nMAssay Description:Binding constant for JAK3(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412)
Affinity DataKd:  12nMAssay Description:Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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