Compile Data Set for Download or QSAR
maximum 50k data
Found 69 Enz. Inhib. hit(s) with all data for entry = 50007641
TargetC-C chemokine receptor type 7(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of CCR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511117(CHEMBL4557289)
Affinity DataIC50:  3nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511117(CHEMBL4557289)
Affinity DataIC50:  3nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 7(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306033(Cenicriviroc | TAK-652 | TBR-652)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of CCR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306033(Cenicriviroc | TAK-652 | TBR-652)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of CCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511118(CHEMBL4456029)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50:  27nMAssay Description:Inhibition of CCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511112(CHEMBL4567446)
Affinity DataIC50:  30nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511112(CHEMBL4567446)
Affinity DataIC50:  31nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataIC50:  80nMAssay Description:Activation of mouse liver PPARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Rattus norvegicus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  340nMAssay Description:Inhibition of rat KHKMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511110(CHEMBL4530491)
Affinity DataIC50:  579nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataIC50:  1.15E+3nMAssay Description:Activation of mouse liver PPARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511111(CHEMBL4476176)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511111(CHEMBL4476176)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511113(CHEMBL4593380)
Affinity DataIC50:  1.83E+4nMAssay Description:Activation of mouse liver PPARalphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT1 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241205(CHEMBL1463512)
Affinity DataIC50:  3.19E+5nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241206(CHEMBL1500542)
Affinity DataIC50:  3.19E+5nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  8.66E+3nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  99nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50090940(3-(2-{4-[3-(2,6-Dichloro-phenyl)-5-methyl-isoxazol...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185707(CHEMBL3822773)
Affinity DataEC50:  4nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241206(CHEMBL1500542)
Affinity DataKd:  6.20E+4nMAssay Description:Binding affinity to recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241205(CHEMBL1463512)
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511114(CHEMBL4438585)
Affinity DataEC50:  59nMAssay Description:Displacement of [125I]GLP-1 from human GLP-1R (7 to 36 residues) expressed in HEK293 or CHO cell membranes after 120 mins by radioligand binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511115(CHEMBL4552590)
Affinity DataEC50:  330nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Affinity DataEC50:  910nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Affinity DataEC50:  2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM150162(BI-10773 | Jardiance | US8980829, EMPAGLIFLOZIN | ...)
Affinity DataEC50:  3nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataEC50:  7.40nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of rat hepatocytes AMPK alpha1/beta2/gamma1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
LigandPNGBDBM50511116(CHEMBL4167177)
Affinity DataEC50:  7.5nMAssay Description:Activation of rat hepatocytes AMPK alpha1/beta2/gamma1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataEC50:  970nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185707(CHEMBL3822773)
Affinity DataEC50:  209nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50: >8.00E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50213714((R)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)p...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  85nMAssay Description:Agonist activity at FXR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511115(CHEMBL4552590)
Affinity DataEC50:  36nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
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