Compile Data Set for Download or QSAR
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Found 38 Enz. Inhib. hit(s) with all data for entry = 50037309
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144942(2'-C-Me-guanosine | 2'-C-methyl-guanosine | 2'-C-m...)
Affinity DataIC50:  130nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144937(2-Amino-9-((2R,3R,5S)-3-hydroxy-5-hydroxymethyl-te...)
Affinity DataIC50:  600nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144947(2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144938(2-Amino-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-hydr...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144948((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144949((2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hyd...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144934((2R,3R,4R,5R)-2-(6-hydroxy-9H-purin-9-yl)-5-(hydro...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50409930(CHEMBL2021379)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144950(3'-deoxyadenosine | 9-(beta-D-3'-Deoxyribofuranosy...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144933((2R,3S,4S,5R)-4-Fluoro-5-hydroxymethyl-2-(6-methyl...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144939((2R,3R,4R,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144945((2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-methy...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144932((2R,3R,4R,5R)-4-Fluoro-2-hydroxymethyl-5-(6-methyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144935((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-3-ethyl-5-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408410(CHEMBL480143)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144936(CHEMBL1090 | VIDARABINE | adenine arabinoside)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144941((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxy...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422565(CHEMBL2311161)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144940((2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408410(CHEMBL480143)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50409930(CHEMBL2021379)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144934((2R,3R,4R,5R)-2-(6-hydroxy-9H-purin-9-yl)-5-(hydro...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144937(2-Amino-9-((2R,3R,5S)-3-hydroxy-5-hydroxymethyl-te...)
Affinity DataEC50:  5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144947(2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144945((2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-methy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144935((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-3-ethyl-5-...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144949((2R,3R,4R,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hyd...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144948((2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataEC50:  300nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144939((2R,3R,4R,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144943((2R,3R,4R,5R)-5-(hydroxymethyl)-3-methyl-2-(9H-pur...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144938(2-Amino-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-hydr...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144941((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144940((2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144936(CHEMBL1090 | VIDARABINE | adenine arabinoside)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144933((2R,3S,4S,5R)-4-Fluoro-5-hydroxymethyl-2-(6-methyl...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422565(CHEMBL2311161)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144932((2R,3R,4R,5R)-4-Fluoro-2-hydroxymethyl-5-(6-methyl...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Isis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50144930(2-Amino-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydr...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition HCV RNA replicationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed