Compile Data Set for Download or QSAR
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Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 1947
TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15372(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-meth...)
Affinity DataIC50:  25nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15370(3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxypheny...)
Affinity DataIC50:  39nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15369(3-(5-Chloro-2,4-dihydroxyphenyl)-4-(4-methoxypheny...)
Affinity DataIC50:  53nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15366(3-(5-Bromo-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl...)
Affinity DataIC50:  62nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15371(3-(5-bromo-2,4-dihydroxyphenyl)-N-ethyl-4-(4-metho...)
Affinity DataIC50:  70nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15373(3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxypheny...)
Affinity DataIC50:  120nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15367(3-(5-Chloro-2,4-dihydroxyphenyl)-4-(4-methoxypheny...)
Affinity DataIC50:  150nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15361((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...)
Affinity DataIC50:  150nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15364(4-chloro-6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5...)
Affinity DataIC50:  210nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15362(4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1...)
Affinity DataIC50:  280nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15368(3-(5-Chloro-2,4-dihydroxyphenyl)-4-(4-methoxypheny...)
Affinity DataIC50:  510nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15359((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Affinity DataIC50:  1.27E+3nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15365(3-(2,4-Dihydroxyphenyl)-4-(4-methoxyphenyl)-5-meth...)
Affinity DataIC50:  4.40E+3nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15363(4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1...)
Affinity DataIC50:  4.73E+3nMpH: 7.4 T: 22°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed