Compile Data Set for Download or QSAR
Report error Found 132 Enz. Inhib. hit(s) with all data for entry = 50017064
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177063BDBM50177063(9-dimethylamino-3-(p-bromophenyl)-3H-5-thia-1,3,6-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177100BDBM50177100(9-dimethylamino-3-cycoheptyl-3H-5-thia-1,3,6-triaz...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177097BDBM50177097(9-Dimethylamino-3-p-tolyl-3H-pyrido[3',2':4,5]thie...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177053BDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177076BDBM50177076(3-(4-Chloro-phenyl)-9-dimethylamino-3H-pyrido[3',2...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177065BDBM50177065(9-dimethylamino-3-(2,4-dimethylphenyl)-3H-5-thia-1...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177063BDBM50177063(9-dimethylamino-3-(p-bromophenyl)-3H-5-thia-1,3,6-...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177085BDBM50177085(3-Cyclopentyl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177097BDBM50177097(9-Dimethylamino-3-p-tolyl-3H-pyrido[3',2':4,5]thie...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177053BDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177055BDBM50177055(9-Dimethylamino-3-(3-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177078BDBM50177078(9-dimethylamino-3-(p-fluorophenyl)-3H-5-thia-1,3,6...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177057BDBM50177057(9-Dimethylamino-3-(4-trifluoromethyl-phenyl)-3H-py...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177055BDBM50177055(9-Dimethylamino-3-(3-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177080BDBM50177080(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177081BDBM50177081(9-dimethylamino-3-(2,4-dichlorophenyl)-3H-5-thia-1...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177059BDBM50177059(3-Cyclooctyl-9-dimethylamino-3H-pyrido[3',2':4,5]t...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177076BDBM50177076(3-(4-Chloro-phenyl)-9-dimethylamino-3H-pyrido[3',2...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177065BDBM50177065(9-dimethylamino-3-(2,4-dimethylphenyl)-3H-5-thia-1...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177096BDBM50177096(3-cycloheptyl -9-dimethylamino-3H-5-thia-1,2,3,6-t...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177079BDBM50177079(9-dimethylamino-3-phenyl-3H-pyrido[3',2':4,5]thien...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177078BDBM50177078(9-dimethylamino-3-(p-fluorophenyl)-3H-5-thia-1,3,6...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177098BDBM50177098(9-dimethylamino-3-cyclopentylmethyl-3H-5-thia-1,3,...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177057BDBM50177057(9-Dimethylamino-3-(4-trifluoromethyl-phenyl)-3H-py...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177074BDBM50177074(9-(N,N-ethylmethylamino)-3-(4'-ethylphenyl)-3H-5-t...)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177084BDBM50177084(9-dimethylamino-3-(2'-methoxy-5'-pyridyl)-3H-5-thi...)
Affinity DataIC50: 39nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177061BDBM50177061(9-cyclopropylamino-3-(4'-ethylphenyl)-3H-5-thia-1,...)
Affinity DataIC50: 41nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177062BDBM50177062(9-dimethylamino-3-(4-methylphenyl)-3H-5-thia-1,3,7...)
Affinity DataIC50: 43nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177093BDBM50177093(9-dimethylamino-2-methyl-3H-5-thia-1,3,6-triazaflu...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177081BDBM50177081(9-dimethylamino-3-(2,4-dichlorophenyl)-3H-5-thia-1...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177054BDBM50177054([3-(4-Ethyl-phenyl)-4-oxo-3,4-dihydro-pyrido[3',2'...)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177070BDBM50177070(9-dimethylamino-3-cyclohexyl-3H-5-thia-1,3,6-triaz...)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177067BDBM50177067(9-Dimethylamino-3-(2-hydroxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177082BDBM50177082(9-dimethylamino-3-(1H-indazol-6-yl)-3H-5-thia-1,3,...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177083BDBM50177083(9-(2'-methoxyethylmethylamino)-3-(4'-ethylphenyl)-...)
Affinity DataIC50: 71nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177068BDBM50177068(9-dimethylamino-3-(1-adamantyl)-3H-5-thia-1,3,6-tr...)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177089BDBM50177089(9-dimethylamino-3-(4'-methyl-1'-cyclohexyl)-3H-1,3...)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177095BDBM50177095(9-Dimethylamino-2-ethyl-3-(4-ethyl-phenyl)-3H-pyri...)
Affinity DataIC50: 84nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177064BDBM50177064(CHEMBL388087 | cid_657896 | 3-Benzyl-9-dimethylami...)
Affinity DataKi:  87nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177066BDBM50177066(9-dimethylamino-3-(4-cyclopropylphenyl)-3H-5-thia-...)
Affinity DataIC50: 87nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177086BDBM50177086(3-(4-Ethyl-phenyl)-9-methylamino-3H-pyrido[3',2':4...)
Affinity DataIC50: 98nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177071BDBM50177071(3-(4-Ethyl-phenyl)-9-(2,2,2-trifluoro-ethylamino)-...)
Affinity DataIC50: 99nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177067BDBM50177067(9-Dimethylamino-3-(2-hydroxy-phenyl)-3H-pyrido[3',...)
Affinity DataKi:  99nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177073BDBM50177073(2-Butyl-9-dimethylamino-3-(4-ethyl-phenyl)-3H-pyri...)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177058BDBM50177058(9-N-azetidinyl-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-...)
Affinity DataIC50: 113nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177082BDBM50177082(9-dimethylamino-3-(1H-indazol-6-yl)-3H-5-thia-1,3,...)
Affinity DataIC50: 122nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177094BDBM50177094(9-Dimethylamino-3-(2-methyl-cyclohexyl)-3H-pyrido[...)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177075BDBM50177075(3-Cyclohexylmethyl-9-dimethylamino-3H-pyrido[3',2'...)
Affinity DataIC50: 139nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177072BDBM50177072(9-dimethylamino-3-(4-methylcyclohexyl)-3H-5-thia-1...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177056BDBM50177056(9-Dimethylamino-3-(2-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataKi:  142nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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