Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 2856
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKi:  0.160nM ΔG°:  -58.2kJ/molepH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKi:  38nM ΔG°:  -44.1kJ/molepH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25381(1,7-dibenzyl-8-[(2-hydroxyethyl)sulfanyl]-3-methyl...)
Affinity DataKi:  106nM ΔG°:  -41.4kJ/mole IC50: 1.72E+3nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25378(7-[(4-chlorophenyl)methyl]-3-methyl-8-sulfanyl-2,3...)
Affinity DataIC50: 2.10E+3nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25385(8-{[(2E)-3-chlorobut-2-en-1-yl]sulfanyl}-7-(2-hydr...)
Affinity DataIC50: 3.75E+3nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25383(7-benzyl-3-methyl-8-[(2Z)-2-[1-(4-nitrophenyl)ethy...)
Affinity DataIC50: 4.60E+3nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25380(1,7-dibenzyl-8-{[(2E)-3-chlorobut-2-en-1-yl]sulfan...)
Affinity DataIC50: 1.09E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25382(2-({7-[(3-bromophenyl)methyl]-3-methyl-2,6-dioxo-2...)
Affinity DataIC50: 1.11E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25390(7-benzyl-3-methyl-8-[(2Z)-2-(1-phenylethylidene)hy...)
Affinity DataIC50: 1.14E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25387(7-[(2Z)-3-chlorobut-2-en-1-yl]-3-methyl-8-[(2Z)-2-...)
Affinity DataIC50: 1.74E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25377(3-({6,7-dimethyl-5-[(1-methylpyridin-1-ium-3-yl)ca...)
Affinity DataIC50: 2.94E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25379(7-benzyl-3-methyl-8-(methylsulfanyl)-2,3,6,7-tetra...)
Affinity DataIC50: 3.01E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25386(3-methyl-8-[(2Z)-2-[(3-nitrophenyl)methylidene]hyd...)
Affinity DataIC50: 3.75E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25388(7-benzyl-3-methyl-8-[(2Z)-2-[(3-nitrophenyl)methyl...)
Affinity DataIC50: 5.00E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25384(7-benzyl-8-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3-dime...)
Affinity DataIC50: 5.77E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

LigandPNGBDBM25389(7-benzyl-3-methyl-8-[(2Z)-2-[(4-nitrophenyl)methyl...)
Affinity DataIC50: 5.79E+4nMpH: 7.0 T: 2°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2008
Entry Details Article
PubMed