Compile Data Set for Download or QSAR
maximum 50k data
Found 85 Enz. Inhib. hit(s) with all data for entry = 50031457
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of wild type AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM25014(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3R...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50307768(7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50256718(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Raf1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313644((E)-3-(2-(6-(cyclopropylamino)-7H-purin-9(8H)-yl)v...)
Affinity DataIC50:  8nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM25014(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3R...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Akt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of erbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50256718(9-phenyl-8-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Akt2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313645(1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Affinity DataIC50:  10nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313645(1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Affinity DataIC50:  12nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50:  12nMAssay Description:Inhibition of Akt2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM25014(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3R...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Akt2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313645(1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Affinity DataIC50:  14nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50244787((R)-2-(1-Hydroxybut-2-ylamino)-6-[3-(2-pyridyl)phe...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  14nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50275756(4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methyl-7-(2...)
Affinity DataIC50:  15nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50307768(7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of erbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  18nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313645(1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Affinity DataIC50:  18nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50:  21nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313644((E)-3-(2-(6-(cyclopropylamino)-7H-purin-9(8H)-yl)v...)
Affinity DataIC50:  25nMAssay Description:Inhibition of wild type AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313646(CHEMBL1080582 | N-cyclohexyl-4-(3-phenyl-5-(piperi...)
Affinity DataIC50:  26nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  35nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  38nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  38nMAssay Description:Inhibition of wild type AblMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313640(CHEMBL1079113 | N-(4-methyl-3-(4-(6-methylpyridin-...)
Affinity DataIC50:  43nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50313645(1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H...)
Affinity DataIC50:  52nMAssay Description:Inhibition of PI3K p110-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  55nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  58nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM15169(1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-y...)
Affinity DataIC50:  58nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  58nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Akt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  68nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50:  79nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50244787((R)-2-(1-Hydroxybut-2-ylamino)-6-[3-(2-pyridyl)phe...)
Affinity DataIC50:  80nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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