Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50002559
TargetVascular endothelial growth factor receptor 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human N-terminal GST/His6-tagged FLT3 (R571 to S993 residues) expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human VEGFR2 expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK8/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of CDK19/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK8/CCNC (unknown origin) using RBER-IRStide as substrate in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant Raf-1 (305 to 648 residues) (unknown origin) expressed in baculovirus expression system using MEk1 as substrate after 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK19 (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK19/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 14nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 14nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse FLK1 (785 to 1367 residues) expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50459996(CHEMBL4227266)
Affinity DataIC50: 17nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant BRAF (409 to 765 residues) (unknown origin) expressed in baculovirus expression system using MEk1 as substrate after 25 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 24nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataIC50: 24nMAssay Description:Inhibition of CDK8/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant BRAF (409 to 765 residues) V599E mutant (unknown origin) expressed in baculovirus expression system using MEk1 as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human N-terminal GST/His6-tagged FLT3 (R571 to S993 residues) expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 66nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human VEGFR2 expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 3(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 190nMAssay Description:Inhibition of FLT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 199nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 206nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 220nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 250nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50459994(CHEMBL4226806 | US11471446, Compound DBA-8)
Affinity DataIC50: 280nMAssay Description:Inhibition of CDK8/CCNC (unknown origin) using RBER-IRStide as substrate in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase inhibitor 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50459994(CHEMBL4226806 | US11471446, Compound DBA-8)
Affinity DataIC50: 640nMAssay Description:Inhibition of p21 (unknown origin)-induced transcription in human HT1080 p21-9-CMV-GFP cells after 3 days by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of CDK9 (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in human 7dF3 cells harboring TCF/LEF WNT-reporter assessed as inhibition of Wnt pathway after 24 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Mouse)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of CDK8/Cyclin-C in R848-stimulated mouse BMDC assessed as upregulation of IL-10 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in human 7dF3 cells harboring TCF/LEF WNT-reporter assessed as inhibition of Wnt pathway after 24 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 4.52E+3nMAssay Description:Inhibition of CDK8 in human LS174T cells harboring TCF/LEF WNT-reporter assessed as inhibition of Wnt pathway after 24 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of CDK8 in human LS174T cells harboring TCF/LEF WNT-reporter assessed as inhibition of Wnt pathway after 24 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM62810(2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed