Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50021500
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM315499(US10172858, Table 1.22)
Affinity DataKi:  1.40nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM31767(3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PI3K p110-alpha incubated for 120 mins in presence of [gamma-33P]ATP by radioactivity based scintillation proximity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal FLAG-tagged mTORC2 (unknown origin) expressed in HeLa cells incubated for 20 mins in presence of ATP by SDS-PAGE based immun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal FLAG-tagged mTORC1 (unknown origin) expressed in HEK293T cells incubated for 20 mins in presence of ATP by SDS-PAGE based im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM31767(3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-y...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PI3K p110-delta incubated for 120 mins in presence of [gamma-33P]ATP by radioactivity based scintillation proximity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM31767(3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-y...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PI3K p110-beta incubated for 120 mins in presence of [gamma-33P]ATP by radioactivity based scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50641312(CHEMBL5570690)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant mTOR using GFP-4E-BP1 as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human recombinant MNK2 expressed in HEK293T cells incubated for 2 hrs in presence of ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 8nMAssay Description:Inhibition of mTOR (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM400813(QL-X-138 | US10000483, Compound II-6)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of Flag-tagged BTK (unknown origin) expressed in HEK293T cells pre-incubated for 30 mins followed by ATP addition and measured after 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant MNK1 expressed in HEK293T cells incubated for 2 hrs in presence of ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50130694(CHEMBL3416305)
Affinity DataIC50: 11nMAssay Description:Inhibition of MNK2 (unknown origin) by high-throughput screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM31767(3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-y...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant PI3K p110-gamma incubated for 120 mins in presence of [gamma-33P]ATP by radioactivity based scintillation proximity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 16nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50641312(CHEMBL5570690)
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3Kalpha (unknown origin) incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM31767(3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-y...)
Affinity DataIC50: 20nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50641309(CHEMBL5572730)
Affinity DataIC50: 22nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 23nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM400813(QL-X-138 | US10000483, Compound II-6)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length MNK2 (unknown origin) expressed in HEK293T cells pre-incubated for 30 mins followed by ATP addition and measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 30nMAssay Description:Inhibition of mTORC1 (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant MNK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 58nMAssay Description:Inhibition of mTORC2 (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50641309(CHEMBL5572730)
Affinity DataIC50: 65nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3K p110-delta (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM400813(QL-X-138 | US10000483, Compound II-6)
Affinity DataIC50: 107nMAssay Description:Inhibition of full length MNK1 (unknown origin) expressed in HEK293T cells pre-incubated for 30 mins followed by ATP addition and measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50130694(CHEMBL3416305)
Affinity DataIC50: 116nMAssay Description:Inhibition of MNK1 (unknown origin) by high-throughput screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM315499(US10172858, Table 1.22)
Affinity DataKi:  152nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM315499(US10172858, Table 1.22)
Affinity DataKi:  165nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 904nMAssay Description:Inhibition of human recombinant MNK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PI3K p110-gamma (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PI3K p110-alpha (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PI3K p110-beta (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MNK1 in human A549 cells assessed as downregulation of eIF4E phosphorylation level incubated for 2 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM315499(US10172858, Table 1.22)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50641310(CHEMBL5594869)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of eIF4E/eIF4G (unknown origin) interaction by TR-FRET-based high-throughput screening analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEukaryotic initiation factor 4A-I(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50641311(CHEMBL5542372)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of EIF4A1 (unknown origin) assessed as ATP hydrolysis incubated for 1 hr in presence of ATP by malachite green assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed