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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50387571
Substrate
n/a
Meas. Tech.
ChEMBL_830489 (CHEMBL2061259)
IC50
20±n/a nM
Citation
 Arai, T; Ohno, M; Inoue, H; Hayashi, S; Aoki, T; Hirokawa, H; Meguro, H; Koga, Y; Oshida, K; Kainoh, M; Suyama, K; Kawai, H Design and synthesis of novel p38a MAP kinase inhibitors: discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety. Bioorg Med Chem Lett 22:5118-22 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50387571
Synonyms:
CHEMBL2058046
Type:
Small organic molecule
Emp. Form.:
C26H27ClN6O2
Mol. Mass.:
490.985
SMILES:
Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1ccccc1Oc1ccnc(Cl)n1)C(C)(C)C
Structure:
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