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Target
C-C motif chemokine 2
Ligand
BDBM14031
Substrate
n/a
Meas. Tech.
ChEMBL_700342 (CHEMBL1647668)
IC50
6918.31±n/a nM
Citation
 Ray, P; Wright, J; Adam, J; Bennett, J; Boucharens, S; Black, D; Cook, A; Brown, AR; Epemolu, O; Fletcher, D; Haunso, A; Huggett, M; Jones, P; Laats, S; Lyons, A; Mestres, J; de Man, J; Morphy, R; Rankovic, Z; Sherborne, B; Sherry, L; van Straten, N; Westwood, P; Zaman, GZ Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. Bioorg Med Chem Lett 21:97-101 (2010) [PubMed]  Article 
Target
Name:
C-C motif chemokine 2
Synonyms:
CCL2 | CCL2_HUMAN | HC11 | MCAF | MCP-1 | MCP1 | Monocyte chemoattractant protein 1 | Monocyte chemotactic and activating factor | Monocyte chemotactic protein 1 | Monocyte secretory protein JE | SCYA2 | Small-inducible cytokine A2
Type:
PROTEIN
Mol. Mass.:
11032.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363188
Residue:
99
Sequence:
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
  
Inhibitor
Name:
BDBM14031
Synonyms:
5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one | CHEMBL1233300 | HA-1100 | Hydroxyfasudil
Type:
Small organic molecule
Emp. Form.:
C14H17N3O3S
Mol. Mass.:
307.368
SMILES:
O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1
Structure:
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