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Target
Neutrophil elastase
Ligand
BDBM104824
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<0.3±0.0 nM
Citation
 Von Nussbaum, F; Karthaus, D; Anlauf, S; Delbeck, M; Li, VM; Meibom, D; Lustig, K Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD US Patent  US8569314 Publication Date 10/29/2013 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM104824
Synonyms:
US8569314, 50
Type:
Small organic molecule
Emp. Form.:
C26H23F3N6O4
Mol. Mass.:
540.4938
SMILES:
CCOC(=O)Nc1nc2N(C(C)=C(C(c3ccc(cc3)C#N)n2n1)C(=O)OCC)c1cccc(c1)C(F)(F)F |c:11|
Structure:
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